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Full-Text Articles in Life Sciences
Zika Virus Infection Causes Temporary Paralysis In Adult Mice With Motor Neuron Synaptic Retraction And Evidence For Proximal Peripheral Neuropathy, John D. Morrey, Alexandre L. R. Oliveira, Hong Wang, Katherine Zukor, Mateus Vidigal De Castro, Venkatraman Siddharthan
Zika Virus Infection Causes Temporary Paralysis In Adult Mice With Motor Neuron Synaptic Retraction And Evidence For Proximal Peripheral Neuropathy, John D. Morrey, Alexandre L. R. Oliveira, Hong Wang, Katherine Zukor, Mateus Vidigal De Castro, Venkatraman Siddharthan
Animal, Dairy, and Veterinary Science Faculty Publications
Clinical evidence is mounting that Zika virus can contribute to Guillain-Barré syndrome which causes temporary paralysis, yet the mechanism is unknown. We investigated the mechanism of temporary acute flaccid paralysis caused by Zika virus infection in aged interferon αβ-receptor knockout mice used for their susceptibility to infection. Twenty-five to thirty-five percent of mice infected subcutaneously with Zika virus developed motor deficits including acute flaccid paralysis that peaked 8-10 days after viral challenge. These mice recovered within a week. Despite Zika virus infection in the spinal cord, motor neurons were not destroyed. We examined ultrastructures of motor neurons and synapses by …
Syringomyelia In An Adult American Paint Horse, Jacqueline P. Kurz, Kate E. Schoenhals, Gordon A. Hullinger, Arnaud J. Van Wettere
Syringomyelia In An Adult American Paint Horse, Jacqueline P. Kurz, Kate E. Schoenhals, Gordon A. Hullinger, Arnaud J. Van Wettere
Animal, Dairy, and Veterinary Science Faculty Publications
Syringomyelia is a form of myelodysplasia defined by the formation of one or more fluid-filled cavities within the spinal cord that do not communicate with the central canal. The defect may be congenital or acquired. Clinical signs correlate to the segment of spinal cord affected and include pain, paresis, proprioceptive deficits, alterations in sensation, scoliosis, and autonomic dysfunction. This report describes the clinical and pathologic changes in a case of acquired syringomyelia in a 10-year-old American Paint Horse mare. The horse had a six-week history of progressive proprioceptive deficits in all four limbs, bilateral pelvic limb ataxia, and muscle fasciculations …
Zika Virus-Induced Acute Myelitis And Motor Deficits In Adult Interferon Αβ/Γ Receptor Knockout Mice, Katherine Zukor, Hong Wang, Venkatraman Siddharthan, Justin G. Julander, John D. Morrey
Zika Virus-Induced Acute Myelitis And Motor Deficits In Adult Interferon Αβ/Γ Receptor Knockout Mice, Katherine Zukor, Hong Wang, Venkatraman Siddharthan, Justin G. Julander, John D. Morrey
Animal, Dairy, and Veterinary Science Faculty Publications
Zika virus (ZIKV) has received widespread attention because of its effect on the developing fetus. It is becoming apparent, however, that severe neurological sequelae, such as Guillian-Barrë syndrome (GBS), myelitis, encephalitis, and seizures can occur after infection of adults. This study demonstrates that a contemporary strain of ZIKV can widely infect astrocytes and neurons in the brain and spinal cord of adult, interferon α/β receptor knockout mice (AG129 strain) and cause progressive hindlimb paralysis, as well as severe seizure-like activity during the acute phase of disease. The severity of hindlimb motor deficits correlated with increased numbers of ZIKV-infected lumbosacral spinal …
Causation Of Acute Flaccid Paralysis By Myelitis And Myositis In Enterovirus-D68 Infected Mice Deficient In Interferon Αβ/Γ Receptor Deficient Mice., John D. Morrey, Hong Wang, Brett L. Hurst, Katherine Zukor, Venkatraman Siddharthan, Arnaud J. Van Wettere, Donal G. Sinex, E. Bart Tarbet
Causation Of Acute Flaccid Paralysis By Myelitis And Myositis In Enterovirus-D68 Infected Mice Deficient In Interferon Αβ/Γ Receptor Deficient Mice., John D. Morrey, Hong Wang, Brett L. Hurst, Katherine Zukor, Venkatraman Siddharthan, Arnaud J. Van Wettere, Donal G. Sinex, E. Bart Tarbet
Animal, Dairy, and Veterinary Science Faculty Publications
Enterovirus D68 (EV-D68) caused a large outbreak in the summer and fall of 2014 in the United States. It causes serious respiratory disease, but causation of associated paralysis is controversial, because the virus is not routinely identified in cerebrospinal fluid. To establish clinical correlates with human disease, we evaluated EV-D68 infection in non-lethal paralysis mouse models. Ten-day-old mice lacking interferon responses were injected intraperitoneally with the virus. Paralysis developed in hindlimbs. After six weeks of paralysis, the motor neurons were depleted due to viral infection. Hindlimb muscles were also infected and degenerating. Even at the earliest stage of paralysis, muscles …