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United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
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The Complete Genome Sequence Of Mycobacterium Avium Subspecies Paratuberculosis, Lingling Li, J. P. Bannantine, Qing Zhang, Alongkon Amonsin, Barbara J. May, David Alt, Nilanjana Banerji, Sagarika Kanjilal, Vivek Kapur
The Complete Genome Sequence Of Mycobacterium Avium Subspecies Paratuberculosis, Lingling Li, J. P. Bannantine, Qing Zhang, Alongkon Amonsin, Barbara J. May, David Alt, Nilanjana Banerji, Sagarika Kanjilal, Vivek Kapur
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne’s disease in cattle and other ruminants. The K-10 genome is a single circular chromosome of 4,829,781 base pairs and encodes 4,350 predicted ORFs, 45 tRNAs, and one rRNA operon. In silico analysis identified >3,000 genes with homologs to the human pathogen, M. tuberculosis (Mtb), and 161 unique genomic regions that encode 39 previously unknown Map genes. Analysis of nucleotide substitution rates with Mtb homologs suggest overall strong selection for a vast majority of these shared mycobacterial …