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Adaptive Design And Flexible Approval Of Clinical Trials, Saeid Delshad Sisi

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Dose-finding clinical trials are among the most critical cornerstones of the healthcare system. In this broad research area, there are many decision making problems that are extremely challenging to address. However, a small improvement may result in significant benefits to the society. Dose-finding clinical trials are extremely expensive and require multiple time-consuming and complicated R&D phases. Despite all the costs and the long time these trials need to conclude (on average over ten years for each new drug/technology), only less than 15\% of these trials successfully end up in a new approved drug entering the market. This problem is even …