Engineering Commons^™

Novel Applications Of Machine Learning In Bioinformatics, Yi Zhang

Theses and Dissertations--Computer Science

Technological advances in next-generation sequencing and biomedical imaging have led to a rapid increase in biomedical data dimension and acquisition rate, which is challenging the conventional data analysis strategies. Modern machine learning techniques promise to leverage large data sets for finding hidden patterns within them, and for making accurate predictions. This dissertation aims to design novel machine learning-based models to transform biomedical big data into valuable biological insights. The research presented in this dissertation focuses on three bioinformatics domains: splice junction classification, gene regulatory network reconstruction, and lesion detection in mammograms.

A critical step in defining gene structures and mRNA …

Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal

Theses and Dissertations--Computer Science

Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …

Automated Network Security With Exceptions Using Sdn, Sergio A. Rivera Polanco

Theses and Dissertations--Computer Science

Campus networks have recently experienced a proliferation of devices ranging from personal use devices (e.g. smartphones, laptops, tablets), to special-purpose network equipment (e.g. firewalls, network address translation boxes, network caches, load balancers, virtual private network servers, and authentication servers), as well as special-purpose systems (badge readers, IP phones, cameras, location trackers, etc.). To establish directives and regulations regarding the ways in which these heterogeneous systems are allowed to interact with each other and the network infrastructure, organizations typically appoint policy writing committees (PWCs) to create acceptable use policy (AUP) documents describing the rules and behavioral guidelines that all campus network …