Engineering Commons^™

Geological 3d Analyses Of Tunnel Faces With Software And Hardware Tools Of Dibit, Stefan Eder, Heiner Kontrus, Florian König, Stefan Eder

Shotcrete for Underground Support XIV

The measurement and visualization of tunnel structures is the main competence of Dibit Messtechnik GmbH (Innsbruck, Austria). As the inventor of modern 3D tunnel surveying at the end of the 1990s, Dibit is a leader in global surveying projects and develops innovative software and hardware tools for geological applications in tunnelling.

In tunnel construction, the trend is towards the comprehensive, digital 3D recording and mapping of tunnel faces, especially to measure and quantify geological structures, and to document geological conditions. This must be done under the pressure of time and the harsh conditions of progressive mining and result in objective, …

Strategies And Software Tools For Engineering Protein Tunnels And Dynamical Gates, Jiri Damborsky, David Bednar, Sergio Marques, Piia Kokkonen, Gaspar Pinto, Joan Planas Iglesias, Milos Musil, Jiri Hon, Lenka Sumbalova, Ondrej Vavra, Jiri Filipovic, Bara Kozlikova, Martin Marek, Zbynek Prokop, Jan Stourac

Enzyme Engineering XXV

Improvements in the catalytic activity, substrate specificity or enantioselectivity of enzymes are traditionally achieved by modification of enzymes’ active sites. We have recently proposed that the enzyme engineering endeavors should target both the active sites and the access tunnels/channels [1,2]. Using the model enzymes haloalkane dehalogenases, we have demonstrated that engineering of access tunnels provides enzymes with significantly improved catalytic properties [3] and stability [4]. User-friendly software tools Caver [5], Caver Analyst [6], CaverDock [7] and Caver Web [8], have been developed for the computational design of protein tunnels/channels; FireProt [9] and HotSpot Wizard [10] for automated design of stabilizing …