Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Knee Joint Biomechanics In Transtibial Amputees In Gait, Cycling, And Elliptical Training, Greg Orekhov, A. Matt Robinson, Scott J. Hazelwood, Stephen M. Klisch
Knee Joint Biomechanics In Transtibial Amputees In Gait, Cycling, And Elliptical Training, Greg Orekhov, A. Matt Robinson, Scott J. Hazelwood, Stephen M. Klisch
Biomedical Engineering
Transtibial amputees may experience decreased quality of life due to increased risk of knee joint osteoarthritis (OA). No prior studies have compared knee joint biomechanics for the same group of transtibial amputees in gait, cycling, and elliptical training. Thus, the goal of this study was to identify preferred exercises for transtibial amputees in the context of reducing risk of knee OA. The hypotheses were: 1) knee biomechanics would differ due to participant status (amputee, control), exercise, and leg type (intact, residual) and 2) gait kinematic parameters would differ due to participant status and leg type. Ten unilateral transtibial amputee and …
Quantifying Proliferative And Surface Marker Heterogeneity In Colony‐Founding Connective Tissue Progenitors And Their Progeny Using Time‐Lapse Microscopy, Edward Kwee, Gerald M. Saidel, Kimerly Powell, Christopher M. Heylman, Cynthia A. Boehm, George F. Muschler
Quantifying Proliferative And Surface Marker Heterogeneity In Colony‐Founding Connective Tissue Progenitors And Their Progeny Using Time‐Lapse Microscopy, Edward Kwee, Gerald M. Saidel, Kimerly Powell, Christopher M. Heylman, Cynthia A. Boehm, George F. Muschler
Biomedical Engineering
Connective tissue progenitors (CTPs) are defined as the heterogeneous population of tissue‐resident stem and progenitor cells that are capable of proliferating and differentiating into connective tissue phenotypes. The prevalence and variation in clonal progeny of CTPs can be characterized using a colony formation assay. However, colony assays do not directly assess the characteristics of the colony‐founding CTP. We performed large, field‐of‐view, time‐lapse microscopy to manually track colonies back to the founding cells. Image processing and analysis was used to characterize the colonies and their founding cells. We found that the traditional colony‐forming unit (CFU) assay underestimates the number of founding …