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Full-Text Articles in Engineering

Automated Segmentation Of Temporal Bone Structures, Daniel Allen Oct 2019

Automated Segmentation Of Temporal Bone Structures, Daniel Allen

Electronic Thesis and Dissertation Repository

Mastoidectomy is a challenging surgical procedure that is difficult to perform and practice. As supplementation to current training techniques, surgical simulators have been developed with the ability to visualize and operate on temporal bone anatomy. Medical image segmentation is done to create three-dimensional models of anatomical structures for simulation. Manual segmentation is an accurate but time-consuming process that requires an expert to label each structure on images. An automatic method for segmentation would allow for more practical model creation. The objective of this work was to create an automated segmentation algorithm for structures of the temporal bone relevant to mastoidectomy. …


A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari Sep 2019

A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari

Electronic Thesis and Dissertation Repository

Radiation therapy is a main component of treatment for many lung cancer patients. However, the respiratory motion can cause inaccuracies in radiation delivery that can lead to treatment complications. In addition, the radiation-induced damage to healthy tissue limits the effectiveness of radiation treatment. Motion management methods have been developed to increase the accuracy of radiation delivery, and functional avoidance treatment planning has emerged to help reduce the chances of radiation-induced toxicity. In this work, we have developed biomechanical model-based techniques for tumor motion estimation, as well as lung functional imaging. The proposed biomechanical model accurately estimates lung and tumor motion/deformation …


Multi-Atlas Segmentation Of The Facial Nerve, Bradley M. Gare Jun 2019

Multi-Atlas Segmentation Of The Facial Nerve, Bradley M. Gare

Electronic Thesis and Dissertation Repository

Medical image segmentation is an important step to identify the shape and position of patient anatomy prior to surgical simulation, surgical rehearsal, and surgical planning. It is crucial that the facial nerve (FN) is segmented accurately as damage to this nerve can severely impact facial expression, speech, and taste. Manual segmentation provides accurate results but is time-consuming and labor-intensive; semi-automatic methods of segmentation are more feasible in a clinical setting and can provide accurate results with minimal user involvement. The objective of this work was to create a novel, open-source, multi-atlas based segmentation algorithm of the entire FN requiring minimal …


Intraoperative Localization Of Subthalamic Nucleus During Deep Brain Stimulation Surgery Using Machine Learning Algorithms, Mahsa Khosravi Apr 2019

Intraoperative Localization Of Subthalamic Nucleus During Deep Brain Stimulation Surgery Using Machine Learning Algorithms, Mahsa Khosravi

Electronic Thesis and Dissertation Repository

This thesis presents a novel technique for localizing the Subthalamic Nucleus (STN) during Deep Brain Stimulation (DBS) surgery. DBS is an accepted treatment for individuals living with Parkinson's Disease (PD). This surgery involves implantation of a permanent electrode inside the STN to deliver electrical current. The STN is a small grey matter structure within the brain, which makes accurate placement a challenging task for the surgical team. Prior to placement of the permanent electrode, intraoperative microelectrode recordings (MERs) of neural activity are used to localize the STN. The placement of the permanent electrode and the success of the stimulation therapy …