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Full-Text Articles in Engineering
Stabilization Of Bimodal Colloidal Systems Via Nanoparticle Haloing In Microgravity., Luke Hawtrey
Stabilization Of Bimodal Colloidal Systems Via Nanoparticle Haloing In Microgravity., Luke Hawtrey
Electronic Theses and Dissertations
Colloidal suspensions typically contain a multi-phase system of solid particles suspended in a liquid medium. Colloids are widely used in industrial applications such as inks, paints, motor oils, foods, cosmetics, and many more. Colloidal systems are typically formed by the interaction of the attractive van der Waals forces and one or more repulsive forces. These repulsive forces include electrostatic repulsion, steric hindrance, and nanoparticle haloing. Nanoparticle Haloing (NPH) is a phenomenon discovered in 2001 as a viable method to stabilize colloidal systems of uncharged silica microparticles using highly charged zirconia nanoparticles. For this thesis the effects of NPH were tested …
Rheological Investigations Of Self-Assembled Block Copolymer Nanocomposites With Complex Architectures, Benjamin Yavitt
Rheological Investigations Of Self-Assembled Block Copolymer Nanocomposites With Complex Architectures, Benjamin Yavitt
Doctoral Dissertations
The self-assembly of block copolymers (BCP) into microphase separated structures is an attractive route to template and assemble functional nanoparticles (NP) into highly ordered nanocomposites and is central to the “bottom up” fabrication of future materials with tunable electronic, optical, magnetic, and mechanical properties. The optimization of the co-assembly requires an understanding of the fundamentals of phase behavior, intermolecular interactions and dynamics of the polymeric structure. Rheology is a novel characterization tool to investigate these processes in such systems that are not accessible by other means. With the combination of X-ray scattering techniques, structure-property relationships are determined as a function …
Surface-Controlled Dissolution Rates: A Case Study Of Nanoceria In Carboxylic Acid Solutions, Eric A. Grulke, Matthew J. Beck, Robert A. Yokel, Jason M. Unrine, Uschi M. Graham, Matthew L. Hancock
Surface-Controlled Dissolution Rates: A Case Study Of Nanoceria In Carboxylic Acid Solutions, Eric A. Grulke, Matthew J. Beck, Robert A. Yokel, Jason M. Unrine, Uschi M. Graham, Matthew L. Hancock
Chemical and Materials Engineering Faculty Publications
Nanoparticle dissolution in local milieu can affect their ecotoxicity and therapeutic applications. For example, carboxylic acid release from plant roots can solubilize nanoceria in the rhizosphere, affecting cerium uptake in plants. Nanoparticle dispersions were dialyzed against ten carboxylic acid solutions for up to 30 weeks; the membrane passed cerium-ligand complexes but not nanoceria. Dispersion and solution samples were analyzed for cerium by inductively coupled plasma mass spectrometry (ICP-MS). Particle size and shape distributions were measured by transmission electron microscopy (TEM). Nanoceria dissolved in all carboxylic acid solutions, leading to cascades of progressively smaller nanoparticles and producing soluble products. The dissolution …
Engineering Of Gold Nanoparticles For Drug Delivery, Fangchao Liu
Engineering Of Gold Nanoparticles For Drug Delivery, Fangchao Liu
Wayne State University Dissertations
Due to their ease of synthesis, versatile surface chemistry, ease of imaging, and biocompatibility, gold nanoparticles (AuNPs) are employed as drug delivery devices in the treatment of respiratory problems associated with spinal cord injury (SCI). We have developed a method for the synthesis of a tripartite nanoconjugate comprised of an AuNP drug carrier chemically conjugated to a transporter protein (wheat germ agglutinin coupled to horseradish peroxidase or WGA-HRP) and to potent SCI drugs. The therapeutic efficacy and biodistribution were studied in a validated animal model. Our results show that a single administration of the nanoconjugate improved diaphragmatic activity at a …