Engineering Commons^™

Evolutionary Polymorphic Neural Networks In Chemical Engineering Modeling, Li Gao

Dissertations

Evolutionary Polymorphic Neural Network (EPNN) is a novel approach to modeling chemical, biochemical and physical processes. This approach has its basis in modern artificial intelligence, especially neural networks and evolutionary computing. EPNN can perform networked symbolic regressions for input-output data, while providing information about both the structure and complexity of a process during its own evolution.

In this work three different processes are modeled: 1. A dynamic neutralization process. 2. An aqueous two-phase system. 3. Reduction of a biodegradation model. In all three cases, EPNN shows better or at least equal performances over published data than traditional thermodynamics /transport or …

Modeling And Experimental Validation Of A Single-Feed Semi-Batch Precipitation Process, Ernesto Uehara-Nagamine

Dissertations

Crystallization is a widely practiced unit operation throughout the chemical and pharmaceutical process industries. Despite its widespread application, crystallization still suffers a disproportionate number of process difficulties due to the complexity of the steps involved in the process. In particular, the final characteristics of the product are strongly affected by the mixing conditions during the process. The development of a validated modeling approach would be highly valuable for the successful prediction of the crystal characteristics under differing mixing conditions.

In the present work, the single-feed semi-batch precipitation process of barium sulfate in a stirred tank was experimentally studied and numerically …

An Investigation Of Centrifugal Blood-Cell Separation, Timothy Edward Roche

Dissertations

This dissertation investigated the centrifugal, batch separation of whole blood into subpopulations of red blood cells (erythrocytes) and white blood cells (leukocytes). Separations took place in a custom-built centrifuge (using a seal-less, anti-twisting feed/withdrawal system) containing, a 25-ml capacity separation chamber. The blood separation chamber had dart-shaped geometry in the radial plane and a constant depth in the axial direction. Separation experiments were performed on whole bovine blood at varying hematocrit, centrifuge speed, and batch duration. A small, companion study of whole human blood separation runs also were conducted; they concentrated on batch duration effect and achieved superior separations.

A …

An Experimental Study Of Dry Particle Coating : Devices, Operating Parameters And Applications, Michelle Ramlakhan Mohan

Dissertations

Dry particle coating, which mechanically coats fine guest particles onto the surfaces of larger host particles, without binders or solvents, is investigated. Several systems of host and guest particles are coated in different devices to study various aspects of dry particle coating. The devices used are Magnetically Assisted Impaction Coating (MAIC) device, Mechanofusion, and the Hybridizer.

MAIC is used to coat fine SiO₂ guest particles onto the surface of larger cornstarch and cellulose host particles. This is done to simultaneously improve the flowability of the host particles, as well as reduce their hydrophilicity. Dry particle coating is used to …

Immobilized Liquid Membranes For Facilitated Transport And Gas Separation, Anjaneya Sarma Kovvali

Dissertations

Separation and purification of gas mixtures is a major area of activity in chemical engineering. Gas separation using facilitated transport membranes has been the subject of considerable research for many years. Immobilized liquid membranes (ILMs) are an important class of facilitated transport membranes. Despite their potential to provide superior performance, they could not achieve commercial success so far due to their instability. Recent research addressed the issue of stability of ILMs by replacing water as the solvent successfully with glycerol. In the present thesis, the relevance of glycerol as an ideal solvent for developing stable ILMs is demonstrated using the …

Microporous Polymeric Membranes Via Melt Processing, Chaiya Chandavasu

Dissertations

Novel ultraporous and microporous membranes from immiscible polymer blends were produced via melt processing and post-extrusion treatments. Polystyrene (PS)/polypropylene (PP) and poly(ethylene terephthalate) (PET)/polypropylene (PP) blend systems with different rheological properties were studied. The blends were first compounded in an intermeshing co-rotating twin-screw extruder and subsequently extruded through a sheet die to obtain the precursor films. These were post treated by uniaxial or biaxial deformation (100-500%) with respect to original dimensions to induce a microporous structure. The porosity is induced by drawing the precursor film at a temperature below the glass transition temperature (T_g) of the minor …