Engineering Commons^™

A Dynamic Programming-Based Approach To Microarray Image Comparison And Registration, Sunil Bosco Rodrigues

Masters Theses

"Microarray technology is increasingly used as a means of high throughput analysis of human, non-human and plant genomes. Manual methods of array production have inherent imperfections and variations of the quality of output data derived from these arrays. A dynamic programming-based approach is presented to validate the quality of such data prior to insertion into evolving databases in order to assign reliably, genetic aberrations to bio-medical functions. Dynamic programming is used for comparing normal and tumor microarray image pairs and a cost function is developed which gives a value representing the difference between the images. Quality of the image pairs …