Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Western University (37)
- California Polytechnic State University, San Luis Obispo (26)
- Purdue University (25)
- University of Kentucky (15)
- University of Arkansas, Fayetteville (14)
-
- New Jersey Institute of Technology (12)
- University of South Florida (12)
- Santa Clara University (11)
- University of Tennessee, Knoxville (11)
- Cleveland State University (10)
- Utah State University (10)
- Virginia Commonwealth University (10)
- Marquette University (8)
- University of Wisconsin Milwaukee (8)
- Wayne State University (8)
- Wright State University (8)
- University of South Carolina (7)
- Washington University in St. Louis (6)
- Michigan Technological University (5)
- University of Massachusetts Amherst (5)
- Clemson University (3)
- Louisiana State University (3)
- Old Dominion University (3)
- University at Albany, State University of New York (3)
- University of Nevada, Las Vegas (3)
- Western Michigan University (3)
- City University of New York (CUNY) (2)
- Florida Institute of Technology (2)
- Louisiana Tech University (2)
- Missouri University of Science and Technology (2)
- Keyword
-
- Applied sciences (13)
- Biomechanics (10)
- Bioengineering (8)
- Biological sciences (8)
- Drug delivery (7)
-
- Health and environmental sciences (6)
- Biomedical Sciences (5)
- Electrospinning (5)
- Ischemia (5)
- Microfluidics (5)
- Nanoparticles (5)
- Arteriogenesis (4)
- Biomedical Engineering (4)
- Biomedical engineering (4)
- EEG (4)
- Kinematics (4)
- Nanotechnology (4)
- Peripheral arterial occlusive disease (4)
- Tissue engineering (4)
- AFM (3)
- Biomaterials (3)
- Department of Biomedical, Industrial & Human Factors Engineering (3)
- Device (3)
- Differentiation (3)
- Finite element analysis (3)
- Magnetic resonance imaging (3)
- Neuroimaging (3)
- Neuromodulation (3)
- Scaffold (3)
- Thermodynamics (3)
- Publication
-
- Electronic Thesis and Dissertation Repository (37)
- Theses and Dissertations (27)
- Open Access Theses (15)
- Master's Theses (14)
- Theses and Dissertations--Biomedical Engineering (13)
-
- Graduate Theses and Dissertations (12)
- USF Tampa Graduate Theses and Dissertations (12)
- Bioengineering Senior Theses (10)
- Doctoral Dissertations (10)
- ETD Archive (10)
- Open Access Dissertations (10)
- Biomedical Engineering (9)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (8)
- Browse all Theses and Dissertations (8)
- Masters Theses (8)
- Theses (8)
- Wayne State University Dissertations (7)
- All Theses and Dissertations (ETDs) (5)
- Dissertations (5)
- Dissertations, Master's Theses and Master's Reports - Open (5)
- Electronic Theses and Dissertations (5)
- Honors Theses (5)
- Master's Theses (2009 -) (5)
- Chancellor’s Honors Program Projects (3)
- Dissertations (1934 -) (3)
- Legacy Theses & Dissertations (2009 - 2024) (3)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (3)
- All Dissertations (2)
- Dissertations & Theses (Open Access) (2)
- Dissertations and Theses (2)
Articles 1 - 30 of 288
Full-Text Articles in Engineering
Real-Time Temperature Imaging Using Ultrasonic Change In Backscattered Energy, Weiyuan Zhao
Real-Time Temperature Imaging Using Ultrasonic Change In Backscattered Energy, Weiyuan Zhao
McKelvey School of Engineering Theses & Dissertations
Thermal therapy from low-temperature cryosurgery to high-temperature ablation of tumors and unwanted electrical pathways has gained increased attention. Temperature imaging (TI) from magnetic resonance studies is the de facto standard for volumetric estimation of temperature. Ultrasound has the advantages of being cheap, portable, non-invasive and non-ionizing. Our group showed in predictions for single scatterers, simulations of scatterer populations and measurements in 1D, 2D and 3D, that CBE changed monotonically with temperature with 1oC accuracy. An obstacle to clinical application of CBE TI is estimation of temperature in real time, which is limited by time for motion compensation (MC). …
Experimental And Theoretical Studies Of Native And Engineered Vascular Tissue Mechanics, Boran Zhou
Experimental And Theoretical Studies Of Native And Engineered Vascular Tissue Mechanics, Boran Zhou
Theses and Dissertations
Background: Implantation of vascular grafts provides a means to restore blood flow in compromised regions of the circulatory system, and thus is used to treat a wide range of cardiovascular diseases. Despite significant advancements in autologous grafting strategies as well as the engineering of synthetic alternatives, mechanical, structural, and compositional incongruities between the graft and the host artery remain as contributing factors to graft failure. The typical failure modality manifests as proximal anastomotic intimal hyperplasia, which places restrictions on the host vessel size currently treated with grafting strategies (> 5 mm internal diameter). In order to improve long-term clinical outcomes, …
On The Application Of Mechanical Vibration In Robotics-Assisted Soft Tissue Intervention, Iman Khalaji
On The Application Of Mechanical Vibration In Robotics-Assisted Soft Tissue Intervention, Iman Khalaji
Electronic Thesis and Dissertation Repository
Mechanical vibration as a way of transmitting energy has been an interesting subject to study. While cyclic oscillation is usually associated with fatigue effect, and hence a detrimental factor in failure of structures and machineries, by controlled transmission of vibration, energy can be transferred from the source to the target. In this thesis, the application of such mechanical vibration in a few surgical procedures is demonstrated.
Three challenges associated with lung cancer diagnosis and treatment are chosen for this purpose, namely, Motion Compensation, tumor targeting in lung Needle Insertion and Soft Tissue Dissection:
- A robotic solution is proposed …
A New Generation Of Polymer/Ceramic Composite Biomaterials For Bone Regeneration, Mehrnaz Salarian
A New Generation Of Polymer/Ceramic Composite Biomaterials For Bone Regeneration, Mehrnaz Salarian
Electronic Thesis and Dissertation Repository
There is a substantial emerging interest for fundamental and applied research on the reinforcement of polymeric materials using nanotechnology. In the biomedical industry, development of novel bone cement composite materials with enhanced mechanical properties is of tremendous potential importance. The most universally used injectable bone cement is made of poly(methyl methacrylate) (PMMA); however, the major disadvantage of PMMA is its non-biodegradability. Polymers such as poly(propylene fumarate) (PPF) and polycaprolactone (PCL) are biodegradable, but suffer from a lack of mechanical properties. The aim of this research was to test the efficacy of these biodegradable polymers integrating nanotechnology for the development of …
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa
Electronic Thesis and Dissertation Repository
The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited a slower …
Digestion Of Municipal Wastewater Biosolids Using An Anaerobic Fluidized Bed Bioreactor (Anfbr), Zhenqi Wang
Digestion Of Municipal Wastewater Biosolids Using An Anaerobic Fluidized Bed Bioreactor (Anfbr), Zhenqi Wang
Electronic Thesis and Dissertation Repository
This research investigated the efficacy of the anaerobic fluidized bed bioreactor (AnFBR) technology in treating municipal wastewater sludges. Primary sludge (PS) and thickened waste activated sludge (TWAS) were studied in two lab-scale AnFBRs using High-density polyethylene (HDPE) as carrier media. PS was investigated at various organic loading rates (OLRs) ranging from 9 to 18 kg chemical oxygen demand (COD)/m3-d corresponding to hydraulic retention times (HRTs) of 2 to 4 days, with maximum COD and volatile suspended solid (VSS) removal efficiency of 70% and 72%, respectively. For TWAS, VSS destruction efficiency varied from 53% at an HRT of 4 …
Design Of A Haptic Interface For Medical Applications Using Magneto-Rheological Fluid Based Actuators, Nima Najmaei
Design Of A Haptic Interface For Medical Applications Using Magneto-Rheological Fluid Based Actuators, Nima Najmaei
Electronic Thesis and Dissertation Repository
This thesis reports on the design, construction, and evaluation of a prototype two degrees-of-freedom (DOF) haptic interface, which takes advantage of Magneto-Rheological Fluid (MRF) based clutches for actuation. Haptic information provides important cues in teleoperated systems and enables the user to feel the interaction with a remote or virtual environment during teleoperation. The two main objectives in designing a haptic interface are stability and transparency. Indeed, deficiencies in these factors in haptics-enabled telerobotic systems has the introduction of haptics in medical environments where safety and reliability are prime considerations. An actuator with poor dynamics, high inertia, large size, and heavy …
Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese
Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese
Doctoral Dissertations
While a great deal of work has been done to analyze cardiac dynamics and mechanics at the organ and tissue levels, there remains much less data regarding these metrics at the single cell level. Additionally, as fields such as regenerative medicine and tissue engineering are beginning to demonstrate greater therapeutic potential, the study and influence of stem cell mechanics on differentiation has become a major area of interest. For these reasons, along with the continued advancement of molecular techniques and assays, there is a growing need to develop functional assays that can integrate and bridge the findings from multiple length …
Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent
Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent
Doctoral Dissertations
In this work, unique high-speed imaging platforms and an array of theoretical analysis methods are used to thoroughly investigate eukaryotic multi-flagellated propulsion using Tritrichomonas foetus as a test case. Through experimental observations through our imaging system with superior resolution and capture rate exceeding that of previous studies, it was discovered for the first time that the T. foetus employs a strategy similar to that of the “run and tumble” strategies found in bacteria and Chlamydomonas; it has two distinct flagellar beating patterns that result in two different body swimming motions, linear and turning swimming.
These two flagella patterns were …
Biomechanical Joint Demands And Functional Outcomes During Manual Wheelchair Use In Pediatric Patients With Spinal Cord Injury, Christine M. Aurit
Biomechanical Joint Demands And Functional Outcomes During Manual Wheelchair Use In Pediatric Patients With Spinal Cord Injury, Christine M. Aurit
Theses and Dissertations
The biomechanical demands of the upper extremities (UEs) during pediatric manual wheelchair (MWC) use have not been fully explored. Children who use MWCs for mobility engage in a range of functional activities that may place large biomechanical demands on the UEs leading to a high risk on overuse injuries. This study aims to analyze the kinematics and kinetics of pediatric manual wheelchair use during propulsion, starting, stopping and weight relief tasks. Fourteen pediatric patients with spinal cord injury were recruited and data were collected using a 14-camera Vicon MX motion analysis system (Oxford Metric Group, Oxford, UK) and a SmartWheel …
An Optogenetic Brain-Machine Interface For Spatiotemporal Neuromodulation, Ryan Andrew Baumgartner
An Optogenetic Brain-Machine Interface For Spatiotemporal Neuromodulation, Ryan Andrew Baumgartner
Theses and Dissertations
Direct neural stimulation has recently become a standard therapy for neurological disorders such as Parkinson's Disease, Essential Tremors, and Dystonia. Currently, deep brain electro-stimulation and neuro-pharmaceutical treatments are the dominant therapeutic options available to the public. As our understanding of brain function and neurological diseases improves, we are able to develop more advanced neuromodulation techniques. These methods could become viable treatment solutions for treating brain dysfunction. Optogenetics, first introduced by a research team led by Karl Deisseroth at Stanford University, has proved to be a versatile technique with remarkable potential to be used in treatments for brain disorders, dysfunction, and …
Induction Of Differentiation Of Dental Pulp-Derived Mesenchymal Stem Cells (Dpsc), Aubrey Young
Induction Of Differentiation Of Dental Pulp-Derived Mesenchymal Stem Cells (Dpsc), Aubrey Young
UNLV Theses, Dissertations, Professional Papers, and Capstones
Mesenchymal stem cells are derived from a variety of human tissues and are being bioengineered and studied for possible uses in the advancement of medicine. Recent efforts are being focused on Dental Pulp Stem Cells (DPSC's) due to the accessibility of this tissue. Many factors influence DPSC quality and quantity, including the specific methods used to isolate, collect, concentrate, and store these isolates once they are removed. Ancillary factors, such as the choice of media, the selection of early versus late passage cells, and cryopreservation techniques may also influence the differentiation potential and proliferative capacity of DPSC isolates.
The objective …
Development Of A Transport System For Advancing Tissue Engineering And Cell Identification, Suzanne Mae Tabbaa
Development Of A Transport System For Advancing Tissue Engineering And Cell Identification, Suzanne Mae Tabbaa
All Dissertations
This work centers on the development of a novel passive transport system for two tissue engineering applications – cell distribution and cell separation. This approach relies on a wicking fiber-based system, derived from the textile field that functions by directing and maintaining transport of cells as well as fluids and biomolecules. This system has the ability to enhance cell movement for both the purpose of cell seeding distribution as well as to isolate specific cell types from heterogeneous cell populations.
The success of spinal fusions and large bone defects is often limited by the decreased surrounding vasculature and the ability …
Development Of A Heart Rate Variability Measurement System Using Embedded Electronics, Naresh Kumar Velmurugan
Development Of A Heart Rate Variability Measurement System Using Embedded Electronics, Naresh Kumar Velmurugan
Graduate Theses and Dissertations
Recent advances in embedded electronics have a remarkable influence on the health care system. One of the most important applications is to monitor the health care of the patients at anytime and anyplace. In the last two decades, many researchers have focused mainly on heart rate variability (HRV) measurements. Patient's heart rate variability should be continuously monitored to help them in case of emergency. Under these circumstances, patients are required to have a HRV measuring kit for a constant observation.
The proposed project focuses on the development of a heart rate variability measurement system with the use of embedded electronics. …
Role Of Sensation In Altered Phalanx Grip Force In Persons With Stroke, Leah R. Enders
Role Of Sensation In Altered Phalanx Grip Force In Persons With Stroke, Leah R. Enders
Theses and Dissertations
Many individuals experience hand impairment after stroke leading to decreased ability to perform daily living activities. Previous research studies have investigated how stroke survivors' pinch grip control differs from healthy individuals, even though many individuals can only grasp with power grip after stroke. Furthermore, many stroke survivors experience tactile sensory deficit in their paretic limb in addition to motor deficit. It is currently unknown how stroke induced tactile sensory deficit affects power grip force directional control, which is important in terms of preventing object slippage and power grip normal force generation. Additionally it is unknown if power grip could be …
Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation In Balb/C Mice, Laura Lenae Burckhardt
Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation In Balb/C Mice, Laura Lenae Burckhardt
Biomedical Engineering
Of the approximately 8 million Americans who suffer from ischemic peripheral arterial occlusive disease (PAOD), many present with intermittent claudication, or pain associated with exercise. Impaired vasodilation of resistance vessels is a potential explanation for this symptom. Occluded arteries can lead to increased flow through collateral vessels, which function as natural bypasses around the obstruction. This increase in blood flow and resulting shear stress can cause outward remodeling, or arteriogenesis, which improves the efficacy of collaterals. However, following femoral artery ligation in a mouse model of chronic ischemia, vasodilation in the stem region of collateral vessels is impaired at day …
Comparative Analysis Of Clavicular Tunnel Confìguration For Coracoclavicular Ligament Reconstruction, Mark Omwansa
Comparative Analysis Of Clavicular Tunnel Confìguration For Coracoclavicular Ligament Reconstruction, Mark Omwansa
Masters Theses
A number of coracoclavicular ligament reconstructions are carried out each year and post surgical fractures of the clavicle have been reported. The primary objective of this research is to develop a comparative metrics that compares clavicular tunnel configurations used in coracoclavicular reconstruction techniques. The goal of this comparison is to reduce post surgical failures due to clavicle fractures. The present analysis compared two techniques { a single 3 mm clavicular tunnel and the other double 6 mm tunnels { experimentally, using Four-point bending testing and Finite Element Analysis (FEA). A unique method, slicing, was used to create an FE clavicle …
Fabrication, Testing And Analysis Of A Fatigue Sensor For Structural Health Monitoring, Subash Gokanakonda
Fabrication, Testing And Analysis Of A Fatigue Sensor For Structural Health Monitoring, Subash Gokanakonda
Dissertations
A novel fatigue monitoring sensor (FMS) is designed, fabricated and tested for detecting and monitoring the fatigue damage and estimating the remaining life of structures and components subjected to cyclic loads. The concept is based on the characteristics of stress / strain life cycle relationship of engineering materials. Sensor consists of alternate slots and strips having different strain magnification factor with respect to the nominal strain. The sensor is designed in such a way that the strips will experience the strain which closely resemble the actual strain distribution in the notch or critical area of the component. The sensor can …
Development And Characterization Of An Autologous Whole Cell Breast Cancer Vaccine, Samantha Leigh Kurtz
Development And Characterization Of An Autologous Whole Cell Breast Cancer Vaccine, Samantha Leigh Kurtz
Graduate Theses and Dissertations
Approximately 40,000 women will die from breast cancer in the United States in 2014. About 90% of these deaths will be due to metastases, rather than the primary tumor and majority of metastases are due to the recurrence and progression of non-metastatic disease. Current adjuvant treatments, such as chemotherapy and radiation, have severe side effects and may result in overtreatment and drug resistance.
Since greater than 90% of patients are diagnosed between stages I-III and have minimal residual disease after treatment, there is an opportunity to treat patients with an autologous breast cancer vaccine. Autologous vaccines under development have a …
Development Of A Novel Device For The Perfusion Driven Decellularization Of Skeletal Muscle, Benjamin Kasukonis
Development Of A Novel Device For The Perfusion Driven Decellularization Of Skeletal Muscle, Benjamin Kasukonis
Graduate Theses and Dissertations
Decellularization of skeletal muscle is a process that removes cellular components of skeletal muscle tissue while leaving behind the intact extracellular matrix (ECM). Skeletal muscle ECM is currently being studied as a biologic scaffold for repairing volumetric muscle loss (VML) because the removal of cells greatly reduces the antigenicity of the donor tissue. Decellularization usually relies on passive diffusion of detergents, surfactants and/or osmotic solutions to strip cells from the ECM. However, passive diffusion alone is usually not sufficient for complete removal of cells from the interior of large pieces of skeletal muscle using detergents, such as sodium dodecyl sulfate …
Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom
Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom
Master's Theses
Peripheral arterial occlusive disease (PAOD) is a globally-prevalent cardiovascular disease in which atherosclerotic plaques narrow arterial lumen diameters and restrict blood flow to downstream tissues. The impact of these occlusions can be mitigated by collateral vessels that connect parallel arterial branches and act as natural bypasses to maintain perfusion. In animal models that lack collateral arterioles, capillaries that connect terminal arteriolar segments can arterialize and form functional collaterals following an ischemic event; however, in the early stages of development, vasodilation is impaired. We explored the mechanism of impaired vasodilation in arterialized collateral capillaries (ACCs) and pre-existing collaterals (PECs) by evaluating …
The Effect Of Artery Bifurcation Angles On Fluid Flow And Wall Shear Stress In The Middle Cerebral Artery, Zachary Ramey Jones
The Effect Of Artery Bifurcation Angles On Fluid Flow And Wall Shear Stress In The Middle Cerebral Artery, Zachary Ramey Jones
Master's Theses
Saccular aneurysms are the abnormal plastic deformation of veins and arteries that can lead to lethal thrombus genesis or internal hemorrhaging. Medication and surgery greatly reduce the mortality rates, but treatment is limited by predicting who will develop aneurysms. A common location for saccular aneurysm genesis is at the main middle cerebral artery (MCA) bifurcation. The main MCA bifurcation is comprised of the M1 MCA segment, parent artery, and two M2 segments, daughter arteries. Studies have found that the lateral angle (LA) ratio of the MCA bifurcation is correlated with aneurysm formation. The LA ratio is defined as the angle …
Protective Effects Of Milk Phospholipids Against Uv-Induced Dna Damage In Human Skin Cells, Lan-Anh Nguyen
Protective Effects Of Milk Phospholipids Against Uv-Induced Dna Damage In Human Skin Cells, Lan-Anh Nguyen
Master's Theses
Skin cancer is the most common type of cancer in the US. The American Academy of Dermatology estimated that more than 3.5 million new cases of skin cancer are diagnosed in the US each year and 1 in 5 Americans will likely to develop skin cancer in their life time. Most cases of skin cancer are caused by exposure to ultraviolet (UV) radiation from the sun. Some of the most common sunscreen ingredients are unstable and can form harmful radicals upon exposure to UV radiation. There is a strong clinical need for a more stable and effective sunscreen ingredient such …
Targeted Drug Delivery System For Kidney And/Or Liver Failure Patients Using Human Serum Albumin, Sean Bedingfield
Targeted Drug Delivery System For Kidney And/Or Liver Failure Patients Using Human Serum Albumin, Sean Bedingfield
Undergraduate Honors Capstone Projects
Compromised liver and/or kidney function reduces the acceptable dosage of a variety of medications that can be administered to patients. These patients still have a need for drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), antivirals, and antibiotics. The project goal is to provide a drug delivery system to accommodate these reduced dosage limits with added therapeutic benefits to address symptoms of liver or kidney failure. Localized drug delivery allows for a smaller, concentrated dose rather than inundating the patient's system with the drug of interest. Human serum albumin (HSA) is a researched candidate for drug delivery with therapeutic properties. HSA …
A Portable Impedance Biosensing System Based On A Laptop With Labview For Rapid Detection Of Avian Influenza Virus, Yixiang Wang
A Portable Impedance Biosensing System Based On A Laptop With Labview For Rapid Detection Of Avian Influenza Virus, Yixiang Wang
Graduate Theses and Dissertations
Avian Influenza Virus (AIV) H5N1 is a highly pathogenic virus found not only in birds but also in human. Rapid and sensitive detection method is needed to help prevent the spread of AIV H5N1. In this study, a portable impedance biosensing system based on a laptop with LabVIEW software was developed for detection of AIV H5N1. First, a virtual instrument was programmed with LabVIEW software to form a platform for impedance measurement, data processing and control. The audio card of a laptop was used as a function generator while a data acquisition card was used with the signal channels for …
A Low-Power Approach For Front End Biological Signal Conditioning, Logan Smith Taylor
A Low-Power Approach For Front End Biological Signal Conditioning, Logan Smith Taylor
Masters Theses
In a lab-on-a-chip (LOC) application, the measurement of small analog signals such as local temperature variation often involves detection of very low-level signals in a noisy micro-scale environment. This is true for other biomedical monitoring systems as well. These systems observe various physiological parameters or electrochemical reactions that need to be tracked electrically. For temperature measurement pyroelectric transducers represent an efficient solution in terms of speed, sensitivity, and scale of integration, especially when prompt and accurate temperature monitoring is desired.
The ability to perform laboratory operations on a small scale using miniaturized LOC devices is a promising biosensing technique. The …
Designing A Biomimetic Testing Platform For Actuators In A Series-Elastic Co-Contraction System, Ryan Tyler Schroeder
Designing A Biomimetic Testing Platform For Actuators In A Series-Elastic Co-Contraction System, Ryan Tyler Schroeder
UNLV Theses, Dissertations, Professional Papers, and Capstones
Actuators determine the performance of robotic systems at the most intimate of levels. As a result, much work has been done to assess the performance of different actuator systems. However, biomimetics has not previously been utilized as a pretext for tuning a series elastic actuator system with the purpose of designing an empirical testing platform. Thus, an artificial muscle tendon system has been developed in order to assess the performance of two distinct actuator types: (1) direct current electromagnetic motors and (2) ultrasonic rotary piezoelectric motors. Because the design of the system takes advantage of biomimetic operating principles such as …
Fabrication And Characterization Of Antioxidant Loaded Liposomes., Brian Gettler
Fabrication And Characterization Of Antioxidant Loaded Liposomes., Brian Gettler
Electronic Theses and Dissertations
Radiation exposure is both a major obstacle in space exploration and an occupational hazard for various careers causing DNA damage and ROS. In order to reduce the effects of radiation, the primary and most explored approach has been focused around mitigation in terms of exposure duration, exposure intensity, and shielding usage. In some situations none of these reduction strategies were viable and so the use of antioxidants is being explored as an alternate strategy for therapeutic purposes. One such antioxidant is curcumin, otherwise known as diferuloylmethane, is a component of turmeric with both antioxidant properties and anti-inflammatory properties. Another antioxidant …
Effect Of Thermal Treatments On Mechanical Properties And Bioactivity Of Third Generation Of Bioactive Glass. A Step For Commercialization Success Of Third Generation Bioactive Glasses, Rajan Pandya
Theses and Dissertations
Unavailability of donors for transplanting bone to help people with orthopedic imparities gave rise to the metal implants that could be made in factories. This seemed like a good solution as it was available to all the people who needed it. It came with limitations such as restricted movement, infection, wear and tear of the surrounding tissue, and rejection. Biologically active implants were introduced by Dr. Larry Hench in 1960s [12]. The field of regenerative medicine has been changing rapidly since then. Biologically active implants facilitate bone regeneration and do not harm the surrounding tissue in any way. The bioactive …
Ultrasound-Guided Mechatronic System For Targeted Delivery Of Cell-Based Cancer Vaccine Immunotherapy In Preclinical Models, Adem Nadjib Hadj Boussaad
Ultrasound-Guided Mechatronic System For Targeted Delivery Of Cell-Based Cancer Vaccine Immunotherapy In Preclinical Models, Adem Nadjib Hadj Boussaad
Electronic Thesis and Dissertation Repository
Injection of dendritic cell (DC) vaccines into lymph nodes (LN) is a promising strategy for eliciting immune responses against cancer, but these injections in mouse cancer models are challenging due to the small target scale (~ 1 mm × 2 mm). Direct manual intranodal injection is difficult and can cause architectural damage to the LN, potentially disrupting crucial interactions between DC and T cells. Therefore, a second-generation ultrasound-guided mechatronic device has been developed to perform this intervention. A targeting accuracy of < 500 μm will enable targeted delivery of the DCs specifically to a LN subcapsular space. The device was redesigned from its original CT-guided edition, which used a remote centre of motion architecture, to be easily integrated onto a commercially available VisualSonics imaging rail system. Subtle modifications were made to ensure simple workflow that allows for live-animal interventions that fall within the knockout periods stated in study protocols. Several calibration and registration techniques were developed in order to achieve an overall targeting accuracy appropriate for the intended application. A variety of methods to quantify the positioning accuracy of the device were investigated. The method chosen involved validating a guided injection into a tissue-mimicking phantom using ultrasound imaging post-operatively to localize the end-point position of the needle tip in the track left behind by the needle. Ultrasound-guided injections into a tissue-mimicking phantom revealed a targeting accuracy of 285 ± 94 μm for the developed robot compared to 508 ± 166 μm for a commercial-available manually-actuated injection device from VisuailSonics. The utility of the robot was also demonstrated by performing in vivo injections into the lymph nodes of mice.