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- Anti-platelet nitric oxide (1)
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Articles 1 - 6 of 6
Full-Text Articles in Engineering
Multi-Modal, Surface-Focused Anticoagulation Using Poly-2-Methoxyethylacrylate Polymer Grafts And Surface Nitric Oxide Release, Surbhi Gupta, Kagya Amoako, Ahmed Suhaib, Keith E. Cook
Multi-Modal, Surface-Focused Anticoagulation Using Poly-2-Methoxyethylacrylate Polymer Grafts And Surface Nitric Oxide Release, Surbhi Gupta, Kagya Amoako, Ahmed Suhaib, Keith E. Cook
Mechanical and Industrial Engineering Faculty Publications
This study examines platelet adhesion on surfaces that combine coatings to limit protein adsorption along with “anti-platelet” nitric oxide (NO) release. Uncoated and poly-2-methoxyethylacrylate (PMEA) coated, gas permeable polypropylene (PP) membranes were placed in a bioreactor to separate plasma and gas flows. Nitrogen with 100/500/1000 ppm of NO was supplied to the gas side as a proof of concept. On the plasma side, platelet rich plasma (PRP, 1 × 108 cell/mL) was recirculated at low (60)/high (300) flows (mL/min). After 8 hours, adsorbed platelets on PP was quantified via a lactate dehydrogenase assay. Compared to plain PP, the PMEA coating …
Vulnerability Assessment And Re-Routing Of Freight Trains Under Disruptions: A Coal Supply Chain Network Application, Ridvan Gedik, Hugh Medal, Chase Rainwater, Edward A. Pohl, Scott J. Mason
Vulnerability Assessment And Re-Routing Of Freight Trains Under Disruptions: A Coal Supply Chain Network Application, Ridvan Gedik, Hugh Medal, Chase Rainwater, Edward A. Pohl, Scott J. Mason
Mechanical and Industrial Engineering Faculty Publications
In this paper, we present a two-stage mixed integer programming (MIP) interdiction model in which an interdictor chooses a limited amount of elements to attack first on a given network, and then an operator dispatches trains through the residual network. Our MIP model explicitly incorporates discrete unit flows of trains on the rail network with time-variant capacities. A real coal rail transportation network is used in order to generate scenarios to provide tactical and operational level vulnerability assessment analysis including rerouting decisions, travel and delay costs analysis, and the frequency of interdictions of facilities for the dynamic rail system.
An Integrated Approach To Developing Technical Communication Skills In Engineering Students, Ronald S. Harichandran, David J. Adams, Michael Collura, Nadiye O. Erdil, David Harding, Jean Nocito-Gobel, Amy Thompson
An Integrated Approach To Developing Technical Communication Skills In Engineering Students, Ronald S. Harichandran, David J. Adams, Michael Collura, Nadiye O. Erdil, David Harding, Jean Nocito-Gobel, Amy Thompson
Engineering and Applied Science Education Faculty Publications
The Project to Integrate Technical Communication Habits (PITCH) is being implemented across seven engineering and computer science undergraduate programs. The overarching goal of PITCH is to develop written, oral and visual communication skills and professional habits in engineering students. PITCH activities begin in the very first semester and are reinforced and extended through all four years of each program. Senior design becomes the culminating experience in which students demonstrate the skills and habits acquired through PITCH courses. Student outcomes for the project were established based on an extensive survey of employers, alumni and faculty. Communication instruments include technical memoranda, poster …
Hemocompatibility Comparison Of Biomedical Grade Polymers Using Rabbit Thrombogenicity Model For Preparing Nonthrombogenic Nitric Oxide Releasing Surfaces, Hitesh Handa, Terry C. Major, Elizabeth Brisbois, Kagya Amoako, Mark E. Meyerhoff, Robert E. Bartlett
Hemocompatibility Comparison Of Biomedical Grade Polymers Using Rabbit Thrombogenicity Model For Preparing Nonthrombogenic Nitric Oxide Releasing Surfaces, Hitesh Handa, Terry C. Major, Elizabeth Brisbois, Kagya Amoako, Mark E. Meyerhoff, Robert E. Bartlett
Mechanical and Industrial Engineering Faculty Publications
Nitric oxide (NO) is an endogenous vasodilator as well as natural inhibitor of platelet adhesion/ activation. Nitric oxide releasing (NOrel) materials can be prepared by doping an NO donor species, such as diazeniumdiolated dibutylhexanediamine (DBHD/N2O2), within a polymer coating. The inherent hemocompatibility properties of the base polymer can also influence the efficiency of such NO release coatings. In this study, four biomedical grade polymers were evaluated in a 4 h rabbit model of thrombogenicity for their effects on extracorporeal circuit thrombus formation and circulating platelet count. At the end of 4 h, Elast-Eon E2As was found to preserve 58% of …
Analysis Of A Chemical Model System Leading To Chiral Symmetry Breaking: Implications For The Evolution Of Homochirality, Brandy N. Morneau, Jaclyn M. Kubala, Carl Barratt, Pauline Schwartz
Analysis Of A Chemical Model System Leading To Chiral Symmetry Breaking: Implications For The Evolution Of Homochirality, Brandy N. Morneau, Jaclyn M. Kubala, Carl Barratt, Pauline Schwartz
Chemistry and Chemical Engineering Faculty Publications
Explaining the evolution of a predominantly homochiral environment on the early Earth remains an outstanding challenge in chemistry. We explore here the mathematical features of a simple chemical model system that simulates chiral symmetry breaking and amplification towards homochirality. The model simulates the reaction of a prochiral molecule to yield enantiomers via interaction with an achiral surface. Kinetically, the reactions and rate constants are chosen so as to treat the two enantiomeric forms symmetrically. The system, however, incorporates a mechanism whereby a random event might trigger chiral symmetry breaking and the formation of a dominant enantiomer; the non-linear dynamics of …
Optimal Dredge Fleet Scheduling Within Environmental Work Windows, Heather Nachtmann, Kenneth N. Mitchell, Chase Rainwater, Ridvan Gedik, Edward A. Pohl
Optimal Dredge Fleet Scheduling Within Environmental Work Windows, Heather Nachtmann, Kenneth N. Mitchell, Chase Rainwater, Ridvan Gedik, Edward A. Pohl
Mechanical and Industrial Engineering Faculty Publications
The U. S. Army Corps of Engineers oversees dredging in hundreds of navigation projects annually, through its fleet of government equipment and through individual contracts with private industry. The research presented here sought to examine the decision to allocate dredge resources to projects systemwide under necessary constraints. These constraints included environmental restrictions on when dredging could take place in response to the migration patterns of turtles, birds, fish, and other wildlife; dredge equipment resource availability; and varying equipment productivity rates that affected project completion times. The paper discusses problem definition and model formulation of optimal dredge fleet scheduling within environmental …