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Full-Text Articles in Engineering
Engineering Multifunctional Adhesive Hydrogel Patches For Biomedical Applications, Aishik Chakraborty, Shana Alexander, Wei Luo, Narisse Al-Salam, Mia Van Oirschot, Sudhir H. Ranganath, Subrata Chakrabarti, Arghya Paul
Engineering Multifunctional Adhesive Hydrogel Patches For Biomedical Applications, Aishik Chakraborty, Shana Alexander, Wei Luo, Narisse Al-Salam, Mia Van Oirschot, Sudhir H. Ranganath, Subrata Chakrabarti, Arghya Paul
Chemical and Biochemical Engineering Publications
Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged as an efficient bioactive multifunctional alternative. Hydrogels are three-dimensional, water-swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties of hydrogels can be modified easily, allowing them to be suitable for various biomedical applications. Moreover, adhesive properties can be imparted to hydrogels through physicochemical manipulations, making them ideal candidates for supplementing or replacing traditional sticking plaster. As a result, sticky hydrogel patches are widely used for transdermal drug …
Drug Delivery On Mg-Mof-74: The Effect Of Drug Solubility On Pharmacokinetics, Neila Pederneira, Kyle Newport, Shane Lawson, Ali A. Rownaghi, Fateme Rezaei
Drug Delivery On Mg-Mof-74: The Effect Of Drug Solubility On Pharmacokinetics, Neila Pederneira, Kyle Newport, Shane Lawson, Ali A. Rownaghi, Fateme Rezaei
Chemical and Biochemical Engineering Faculty Research & Creative Works
Biocompatible metal-organic frameworks (MOFs) have emerged as potential nanocarriers for drug delivery applications owing to their tunable physiochemical properties. Specifically, Mg-MOF-74 with soluble metal centers has been shown to promote rapid pharmacokinetics for some drugs. In this work, we studied how the solubility of drug impacts the pharmacokinetic release rate and delivery efficiency by impregnating various amounts of ibuprofen, 5-fluorouracil, and curcumin onto Mg-MOF-74. The characterization of the drug-loaded samples via X-ray diffraction (XRD), N2 physisorption, and Fourier transform infrared (FTIR) confirmed the successful encapsulation of 30, 50, and 80 wt % of the three drugs within the MOF structure. …
Transport Phenomena With Reactions In Drug Delivery: Towards A Quantitative Description, Xianjie Qiu, Parthasakha Neogi
Transport Phenomena With Reactions In Drug Delivery: Towards A Quantitative Description, Xianjie Qiu, Parthasakha Neogi
Chemical and Biochemical Engineering Faculty Research & Creative Works
A Distributed System Called a Krogh Cylinder is Used Here to Quantify the Transport of a Solute from the Capillary into the Extravascular Tissue. the Capillary Network is Broken Down into Cylindrical Cells, Each Containing a Capillary and an Appropriate Amount of Extravascular Tissue. the Flow in the Cylinder Model Has Two-Dimensional Velocities, Which Are in the Axial and Radial Directions. All Parameters of the System, together with the Geometric Ones, Have Been Included in the Model. for a Given Bioavailability, the Uptakes of Reactive and Nonreactive Solutes Have Been Obtained. Very Large or Massive Molecules Have Been Considered. the …