Engineering Commons^™

Multicellular Models Bridging Intracellular Signaling And Gene Transcription To Population Dynamics, Mohammad Aminul Islam, Satyaki Roy, Sajal K. Das, Dipak Barua

Computer Science Faculty Research & Creative Works

Cell signaling and gene transcription occur at faster time scales compared to cellular death, division, and evolution. Bridging these multiscale events in a model is computationally challenging. We introduce a framework for the systematic development of multiscale cell population models. Using message passing interface (MPI) parallelism, the framework creates a population model from a single-cell biochemical network model. It launches parallel simulations on a single-cell model and treats each stand-alone parallel process as a cell object. MPI mediates cell-to-cell and cell-to-environment communications in a server-client fashion. In the framework, model-specific higher level rules link the intracellular molecular events to cellular …