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Cell Population Modelling Of Yeast Glycolytic Oscillations, Michael A. Henson, Dirk Muller, Matthias Reuss
Cell Population Modelling Of Yeast Glycolytic Oscillations, Michael A. Henson, Dirk Muller, Matthias Reuss
Michael A Henson
We investigated a cell-population modelling technique in which the population is constructed from an ensemble of individual cell models. The average value or the number distribution of any intracellular property captured by the individual cell model can be calculated by simulation of a sufficient number of individual cells. The proposed method is applied to a simple model of yeast glycolytic oscillations where synchronization of the cell population is mediated by the action of an excreted metabolite. We show that smooth one-dimensional distributions can be obtained with ensembles comprising 1000 individual cells. Random variations in the state and}or structure of individual …
Dynamics And Control Of Cell Populations In Continuous Bioreactors, Prodromos Daoutidis, Michael A. Henson
Dynamics And Control Of Cell Populations In Continuous Bioreactors, Prodromos Daoutidis, Michael A. Henson
Michael A Henson
Continuous bioreactors are critical unit operations in a wide variety of biotechnological processes. While they can be viewed as chemical reactors, bioreactors offer unique modeling and control challenges due to the complexity of the underlying biochemical reactions and the distributed properties of the cell population. The dynamic behavior of continuous bioreactors can be strongly affected by variations between individual cells that are captured only with cell population models. The objective of this paper is to outline recent progress in dynamic analysis and feedback control of continuous bioreactors described by cell population models. The industrially important process of continuous yeast production …