Engineering Commons^™

Mapping The Molecular Interface Of A Gpcr Dimer, Zhenqi Li

Theses - ALL

G-protein-coupled receptors (GPCRs) are the most diverse membrane proteins in eukaryotes that transmit chemical signals to the cell. GPCRs are considered the largest family of targets for approved drugs on the market. Sphingosine 1-phosphate receptor 1 (S1P1), a widely expressed GPCR protein in many cell types, performs signal transduction function not only in the monomeric state but also in the dimeric or complex oligomeric states. However, the detail of the S1P1 assembly is still not clearly understood. Cholesterol is believed to affect S1P1 dimerization, but the details of the cholesterol-binding sites with S1P1 are not well understood. In this project, …