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Articles 1 - 7 of 7
Full-Text Articles in Engineering
Assessment Of Differences Between Near-Surface Air And Soil Temperatures For Reliable Detection Of High-Latitude Freeze And Thaw States, Farjana Shati, Satya Prakash, Hamid Norouzi, Reginald Blake
Assessment Of Differences Between Near-Surface Air And Soil Temperatures For Reliable Detection Of High-Latitude Freeze And Thaw States, Farjana Shati, Satya Prakash, Hamid Norouzi, Reginald Blake
Publications and Research
Near-surface air temperature and the underlying soil temperature are among the key components of the Earth’s surface energy budget, and they are important variables for the comprehensive assessment of global climate change. Better understanding of the difference in magnitude between these two variables over high-latitude regions is also crucial for accurate detections of freeze and thaw (FT) states. However, these differences are not usually considered and included in current remote sensing-based FT detection algorithms. In this study, the difference between near-surface air temperature at the 2-meter height and soil temperature at the 5-centimeter depth is assessed using ground-based observations that …
Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher
Chelator-Free Radiolabeling Of Serrs Nanoparticles For Whole-Body Pet And Intraoperative Raman Imaging, Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Darjus-Felix Tschaharganeh, Chun-Hao Huang, Scott W. Lowe, Charles Michael Drain, Moritz F. Kircher
Publications and Research
A single contrast agent that offers whole-body non-invasive imaging along with the superior sensitivity and spatial resolution of surface-enhanced resonance Raman scattering (SERRS) imaging would allow both pre-operative mapping and intraoperative imaging and thus be highly desirable. We hypothesized that labeling our recently reported ultrabright SERRS nanoparticles with a suitable radiotracer would enable pre-operative identification of regions of interest with whole body imaging that can be rapidly corroborated with a Raman imaging device or handheld Raman scanner in order to provide high precision guidance during surgical procedures. Here we present a straightforward new method that produces radiolabeled SERRS nanoparticles for …
Insights Into The Binding Mode Of Mek Type-Iii Inhibitors. A Step Towards Discovering And Designing Allosteric Kinase Inhibitors Across The Human Kinome, Zheng Zhao, Lei Xie, Philip E. Bourne
Insights Into The Binding Mode Of Mek Type-Iii Inhibitors. A Step Towards Discovering And Designing Allosteric Kinase Inhibitors Across The Human Kinome, Zheng Zhao, Lei Xie, Philip E. Bourne
Publications and Research
Protein kinases are critical drug targets for treating a large variety of human diseases. Type- III kinase inhibitors have attracted increasing attention as highly selective therapeutics. Thus, understanding the binding mechanism of existing type-III kinase inhibitors provides useful insights into designing new type-III kinase inhibitors. In this work, we have systematically studied the binding mode of MEK-targeted type-III inhibitors using structural systems pharmacology and molecular dynamics simulation. Our studies provide detailed sequence, structure, interaction-fingerprint, pharmacophore and binding-site information on the binding characteristics of MEK type-III kinase inhibitors. We hypothesize that the helix-folding activation loop is a hallmark allosteric binding site …
Development Of Geospatial And Temporal Characteristics For Hispaniola’S Lake Azuei And Enriquillo Using Landsat Imagery, Mahrokh Moknatian, Michael Piasecki, Jorge Gonzalez
Development Of Geospatial And Temporal Characteristics For Hispaniola’S Lake Azuei And Enriquillo Using Landsat Imagery, Mahrokh Moknatian, Michael Piasecki, Jorge Gonzalez
Publications and Research
In this paper, we used Landsat imagery for water body identification to create a novel 36-year surface area extent time series for lakes Azuei (Haiti) and Enriquillo (Dominican Republic) aimed at illuminating the dramatic temporal changes of these two lakes not just at yearly but at monthly or even sub-monthly scales. We used the Normalized Difference Water Index (NDWI) to extract water features and we also used spatial differentiation and thresholding techniques to remove clouds and associated shadows from the scene that were then passed through gap filling algorithms to complete and extract the lake extent polygons. We also explored …
Toward Measuring Network Aesthetics Based On Symmetry, Zengqiang Chen, Matthias Dehmer, Frank Emmert-Streib, Abbe Mowshowitz, Yongtang Shi
Toward Measuring Network Aesthetics Based On Symmetry, Zengqiang Chen, Matthias Dehmer, Frank Emmert-Streib, Abbe Mowshowitz, Yongtang Shi
Publications and Research
In this exploratory paper, we discuss quantitative graph-theoretical measures of network aesthetics. Related work in this area has typically focused on geometrical features (e.g., line crossings or edge bendiness) of drawings or visual representations of graphs which purportedly affect an observer’s perception. Here we take a very different approach, abandoning reliance on geometrical properties, and apply information-theoretic measures to abstract graphs and networks directly (rather than to their visual representaions) as a means of capturing classical appreciation of structural symmetry. Examples are used solely to motivate the approach to measurement, and to elucidate our symmetry-based mathematical theory of network aesthetics.
Proof Of Concept: Development Of Snow Liquid Water Content Profiler Using Cs650 Reflectometers At Caribou, Me, Usa, Carlos L. Pérez Díaz, Jonathan Muñoz, Tarendra Lakhankar, Reza Khanbilvardi, Peter Romanov
Proof Of Concept: Development Of Snow Liquid Water Content Profiler Using Cs650 Reflectometers At Caribou, Me, Usa, Carlos L. Pérez Díaz, Jonathan Muñoz, Tarendra Lakhankar, Reza Khanbilvardi, Peter Romanov
Publications and Research
The quantity of liquid water in the snowpack defines its wetness. The temporal evolution of snow wetness’s plays a significant role in wet-snow avalanche prediction, meltwater release, and water availability estimations and assessments within a river basin. However, it remains a difficult task and a demanding issue to measure the snowpack’s liquid water content (LWC) and its temporal evolution with conventional in situ techniques. We propose an approach based on the use of time-domain reflectometry (TDR) and CS650 soil water content reflectometers to measure the snowpack’s LWC and temperature profiles. For this purpose, we created an easily-applicable, low-cost, automated, and …
A Comparison Of Modis/Viirs Cloud Masks Over Ice-Bearing River: On Achieving Consistent Cloud Masking And Improved River Ice Mapping, Simon Kraatz, Reza Khanbilvardi, Peter Romanov
A Comparison Of Modis/Viirs Cloud Masks Over Ice-Bearing River: On Achieving Consistent Cloud Masking And Improved River Ice Mapping, Simon Kraatz, Reza Khanbilvardi, Peter Romanov
Publications and Research
The capability of frequently and accurately monitoring ice on rivers is important, since it may be possible to timely identify ice accumulations corresponding to ice jams. Ice jams are dam-like structures formed from arrested ice floes, and may cause rapid flooding. To inform on this potential hazard, the CREST River Ice Observing System (CRIOS) produces ice cover maps based on MODIS and VIIRS overpass data at several locations, including the Susquehanna River. CRIOS uses the respective platform’s automatically produced cloud masks to discriminate ice/snow covered grid cells from clouds. However, since cloud masks are produced using each instrument’s data, and …