Engineering Commons^™

Dynamic Thermal And Power Management: From Computers To Buildings, Yong Fu

McKelvey School of Engineering Theses & Dissertations

Thermal and power management have become increasingly important for both computing and physical systems. Computing systems from real-time embedded systems to data centers require effective thermal and power management to prevent overheating and save energy. In the mean time, as a major consumer of energy buildings face challenges to reduce the energy consumption for air conditioning while maintaining comfort of occupants. In this dissertation we investigate dynamic thermal and power management for computer systems and buildings. (1) We present thermal control under utilization bound (TCUB), a novel control-theoretic thermal management algorithm designed for single core real-time embedded systems. A salient …

Engineering Poly(Ethylene Glycol) Materials To Promote Cardiogenesis, Amanda Walker Smith

McKelvey School of Engineering Theses & Dissertations

Heart failure is one of the leading causes of death worldwide, and the current costs of treatment put a significant economic burden on our societies. After an infarction, fibrotic tissue begins to form as part of the heart failure cascade. Current options to slow this process include a wide range of pharmaceutical agents, and ultimately the patient may require a heart transplant. Innovative treatment approaches are needed to bring down costs and improve quality of life. The possibility of regenerating or replacing damaged tissue with healthy cardiomyocytes is generating considerable excitement, but there are still many obstacles to overcome. First, …

Polarization Imaging Sensors In Advanced Feature Cmos Technologies, Raphael Njoroge Njuguna

McKelvey School of Engineering Theses & Dissertations

The scaling of CMOS technology, as predicted by Moore's law, has allowed for realization of high resolution imaging sensors and for the emergence of multi-mega-pixel imagers. Designing imaging sensors in advanced feature technologies poses many challenges especially since transistor models do not accurately portray their performance in these technologies. Furthermore, transistors fabricated in advanced feature technologies operate in a non-conventional mode known as velocity saturation. Traditionally, analog designers have been discouraged from designing circuits in this mode of operation due to the low gain properties in single transistor amplifiers. Nevertheless, velocity saturation will become even more prominent mode of operation …

Generating High Purity Embryonic Stem Cell-Derived Cell Populations For Transplantation Following Spinal Cord Injury, Dylan A. Mccreedy

McKelvey School of Engineering Theses & Dissertations

Embryonic stem cells hold great potential for cell replacement strategies in the central nervous system. Pre-differentiation into various neural cell types can help generate tissue-specific cell populations that can replace cells and tissue lost due to do injury or disease. A small number of undifferentiated pluripotent stem cells persist in most transplant populations even after pre-differentiation. Given the right environment, i.e. biomaterial scaffolds, these cells can lead to tumor formation thereby eliminating any potential therapeutic benefit. This dissertation focused on the development of high purity embryonic stem cell-derived cell populations devoid of pluripotent stem cells for transplantation into the central …

Improving Radiotherapy Targeting For Cancer Treatment Through Space And Time, Camille Noel

McKelvey School of Engineering Theses & Dissertations

Radiotherapy is a common medical treatment in which lethal doses of ionizing radiation are preferentially delivered to cancerous tumors. In external beam radiotherapy, radiation is delivered by a remote source which sits several feet from the patient's surface. Although great effort is taken in properly aligning the target to the path of the radiation beam, positional uncertainties and other errors can compromise targeting accuracy. Such errors can lead to a failure in treating the target, and inflict significant toxicity to healthy tissues which are inadvertently exposed high radiation doses.

Tracking the movement of targeted anatomy between and during treatment fractions …