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Topological Biclustering Artmap, Raghu Yelugam
Topological Biclustering Artmap, Raghu Yelugam
Masters Theses
”Detection of gene mutations is central for assessing genetic factors affecting disease predisposition, genetic causes of a particular disease, and gene-targeted treatment. DNA microarray methods are widely used to detect mutations by contrasting the expression levels of thousands of genes together under varying experimental conditions. The experimental conditions could be diseased cell states compared with the normal cell states. Biclustering, a robust exploratory data analysis tool, can be applied to microarray data to detect subsets of genes that co-express highly only for a subset of experimental conditions. Such detection is crucial for gaining insights into gene regulatory networks, differential gene …
Fuzzy Adaptive Resonance Theory: Applications And Extensions, Clayton Parker Smith
Fuzzy Adaptive Resonance Theory: Applications And Extensions, Clayton Parker Smith
Masters Theses
"Adaptive Resonance Theory, ART, is a powerful clustering tool for learning arbitrary patterns in a self-organizing manner. In this research, two papers are presented that examine the extensibility and applications of ART. The first paper examines a means to boost ART performance by assigning each cluster a vigilance value, instead of a single value for the whole ART module. A Particle Swarm Optimization technique is used to search for desirable vigilance values. In the second paper, it is shown how ART, and clustering in general, can be a useful tool in preprocessing time series data. Clustering quantization attempts to meaningfully …