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The Role Of Cavitation In Acoustically Activated Drug Delivery, Mario A. Diaz, Ghaleb A. Husseini, William G. Pitt, Eric S. Richardson, Douglas A. Christensen
The Role Of Cavitation In Acoustically Activated Drug Delivery, Mario A. Diaz, Ghaleb A. Husseini, William G. Pitt, Eric S. Richardson, Douglas A. Christensen
Faculty Publications
The triblock copolymer, Pluronic P105, has been found to be an ideal ultrasonically activated drug delivery vehicle because it forms micelles with hydrophobic polypropylene oxide cores that sequester hydrophobic drugs (Fig. 1). These micelles release their contents upon the application of low frequency ultrasound [1]such that drugs can be released specifically at the ultrasonicated region (Fig. 2). Such ultrasonically controlled release has been effective against cancer cells in vitro [2] and in vivo [3]. This poster presents our results showing that collapse cavitation is associated with drug release. Cavitation is generally divided into two types of behavior. Stable cavitation is …
Polymerization Kinetics Of Peo-B-Pnipaam Block Copolymers, William G. Pitt, Yi Zeng
Polymerization Kinetics Of Peo-B-Pnipaam Block Copolymers, William G. Pitt, Yi Zeng
Faculty Publications
Our research in ultrasonic activated drug delivery motivated us to develop polymeric micelles that sequester hydrophobic drugs (Fig. 1) until they are sheared open by cavitation events produced by low frequency ultrasound (Fig. 2). [1] Using this type of drug delivery system, micelles sequestering drug can circulate freely without releasing their drug until they flow through a tumor or other tissue insonated by low frequency ultrasound. There they release part of their drug (Fig. 3). [2,3] This drug delivery technology was used to reduce tumors in a rat model [4] using block copolymers of PEO and PPO. However, we are …