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Effects Of Operating And Geometric Variables On Hydrodynamics And Tablet Dissolution In Standard And Modified Dissolution Testing Apparatuses 2, Yimin Wang
Dissertations
Dissolution testing is routinely conducted in the pharmaceutical industry to provide critical in vitro drug release information for quality control purposes, and especially to assess batch-to-batch consistency of solid oral dosage forms such as tablets. Among the different types of apparatuses listed in the United States Pharmacopoeia (USP), the most commonly used dissolution system for solid dosage forms is the USP Dissolution Testing Apparatus 2, consisting of an unbaffled, hemispherical-bottomed vessel equipped with a 2-blade radial impeller.
Despite its extensive use in industry and a large body of work, some key aspects of the hydrodynamics of Apparatus 2 have received …