Engineering Commons^™

Preclinical Examination Of A Nerve Specific Fluorophore Using Ex Vivo Human Tissues, Logan Michael Bateman

Dartmouth College Master’s Theses

Fluorescence-guided surgery (FGS) is a nascent field which seeks to improve patient safety and surgical outcomes using fluorescent agents known as fluorophores. Fluorophores are molecules which upon excitation with a specific wavelength of light emit a photon of a specific wavelength which can be detected using a modified camera system. Creation and translation of a fluorophore for clinical use is a costly, laborious, and time intensive process. Only a handful of fluorophores have received FDA approval and they required multiple years of tightly regulated clinical trials. Prior to these first-in-human studies these agents are subject to a litany of preclinical …

Latent Auto-Recursive Composition Engine, Yenkai Huang

Dartmouth College Master’s Theses

This thesis investigates the shifting boundaries of art in the era of Generative AI, critically examining the essence of art and the legitimacy of AI-generated works. Despite significant advancements in the quality and accessibility of art through generative AI, such creations frequently encounter skepticism regarding their status as authentic art. To address this skepticism, the study explores the role of creative agency in various generative AI workflows and introduces an "artist-in-the-loop" system tailored for image generation models like Stable Diffusion. This system aims to deepen the artist's engagement and understanding of the creative process. Additionally, a novel tool, the Latent …

Thematic Synthesis: Rethinking Generative Music With Compositional Understanding In Game And Software Development, Jasper Moore Tucker

Dartmouth College Master’s Theses

Generative music, first introduced by composers like Brian Eno and David Cope in the mid-to-late 20th century, has evolved through many stages, with diverse applications across music and technology companies as well as the game industry. However, despite this widespread interest, there remains a notable lack of the foundational understanding of composition and individual expressiveness in current generative systems that was apparent in the work of early composers. This paper advocates for a shift towards prioritizing compositional thought in system design to foster greater diversity and innovation within generative music. To demonstrate this approach, a novel system synthesizing two distinct …

Geometric Multi-Resolution Analysis Across Signals, Images, And Networks, Felicia Schenkelberg

Dartmouth College Master’s Theses

This research delves into the transformative potential of Geometric Multi-Resolution Analysis (GMRA) as a robust tool for dimensionality reduction and data analysis in the context of high-dimensional graphs. Statistical techniques for classification have historically been tailored for scenarios wherein the number of observations significantly exceeds the number of features, a paradigm characteristic of low-dimensional datasets. However, recent advancements in technologies have ushered in a transformative era in data collection practices across diverse domains, resulting in the acquisition of extensive feature measurements. As a result of this shift, datasets have transitioned into a high-dimensional realm wherein the number of features significantly …

Towards A Wearable Device For Measuring Impedance Plethysmography Of The Radial Artery, Pritom Chowdhury

Dartmouth College Master’s Theses

Recent advancements in bioimpedance technology have demonstrated significant promise in the application of cardiac health monitoring. This research explores the design and development of a forearm-based wearable bioimpedance device for non-invasive measurement of heart rate and respiratory rate at an accuracy level comparable to medical-grade monitors. It utilizes a tetrapolar electrode configuration to analyze bioimpedance changes in the radial artery due to blood flow.

An ongoing aspect of this work involves the preliminary development of an embedded framework intended to integrate signal generation, acquisition, and processing within the device to achieve compact and efficient system design, anticipated to contribute to …

A Political Theory Of Engineered Systems And A Study Of Engineering And Justice Workshops, Dominic David Carrese

Dartmouth College Master’s Theses

Since there are good reasons to think that some engineered systems are socially undesirable—for example, internal combustion engines that cause climate change, algorithms that are racist, and nuclear weapons that can destroy all life—there is a well-established literature that attempts to identify best practices for designing and regulating engineered systems in order to prevent harm and promote justice. Most of this literature, especially the design theory and engineering justice literature meant to help guide engineers, focuses on environmental, physical, social, and mental harms such as ecosystem and bodily poisoning, racial and gender discrimination, and urban alienation. However, the literature that …

Advancements In Sarcoma- And Nerve-Specific Fluorescence Imaging For Surgical Guidance, Kendra A. Hebert

Dartmouth College Master’s Theses

Fluorescence guided surgery (FGS) is an evolving field that aims to improve patient outcomes by using fluorophores to identify important tissues during surgery, such as tumors and nerves. In this thesis work, we explored different methods of identifying nerve and tumor tissues for FGS and a novel fluorescence-based method to determine the depths of these structures.

Researchers have explored using fluorescence guided surgery for surgical resection of cancerous tissues, including recent work by our group focusing on identifying soft tissue sarcomas with ABY-029, an epidermal growth factor receptor targeting probe. However, our preclinical and clinical work shows no single reporter …