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Synthesis Of Acetylene Diols With The Participation Of The Bu4noh/Dmso/H2o Catalytic Systems, Muyassar K. Salieva, Odiljon E. Ziyadullayev, Guzal K. Otamukhamedova, Rifkat F. Talipov, Lochin K. Ablakulov
Synthesis Of Acetylene Diols With The Participation Of The Bu4noh/Dmso/H2o Catalytic Systems, Muyassar K. Salieva, Odiljon E. Ziyadullayev, Guzal K. Otamukhamedova, Rifkat F. Talipov, Lochin K. Ablakulov
CHEMISTRY AND CHEMICAL ENGINEERING
The purpose of this work in this study, acetylene alcohols containing heteroatomic substituents in their molecular composition- 2-(-thiophen-2-yl)but-3-yn-2-ol, 2-(3-methylthiophen-2-yl)but-3-yn-2-ol, 2-(furan-2-yl)but-3yn-2-ol, 2-(pyridin-4-yl)but-3-yn-2-ol, 2-(5-chlorothiophen-2-yl)but-3-yn-2-ol, 2-(5-bromothiophen-2yl)but-3-yn-2-ol acetylene diols were synthesized based on the reaction with acetone in a dimethyl sulfoxide solvent in the presence of the Bu4NOH/DMSO/H2O catalytic system. The influence of the molar ratio of starting materials, reaction duration, temperature, nature of the catalyst and solvents on the product yield was systematically studied. The composition, purity and structure of the new generation of synthesized acetylenediols have been confirmed by modern physicochemical methods. The mechanism of the reaction process …
Synthesis Of Aromatic Acetylene Alcohols Using Complex Catalytic Systems, Odiljon Ziyadullaev, Guzal Otamukhamedova, Abduvakhab Ikramov, Saida Abdurakhmanova, Otabek Boytemirov
Synthesis Of Aromatic Acetylene Alcohols Using Complex Catalytic Systems, Odiljon Ziyadullaev, Guzal Otamukhamedova, Abduvakhab Ikramov, Saida Abdurakhmanova, Otabek Boytemirov
CHEMISTRY AND CHEMICAL ENGINEERING
Some cyclic ketones (cyclopentanone, cyclohexanone, 2-methylcyclohexanone, menthol, camphor and adamantanone) enantioselective alkynylation reactions with phenylacetylene have been studied in the presence of complex catalytic systems - Zn(OTf)2/NЕt3/MeCN, 3,3′-Ph2BINOL-2Li/TGF and BuLi/KOtBu/TGF. Synthesis were performed new aromatic acetylene alcohols – 1-(2-phenylathinyl) cyclopentanol (1), 1-(2-phenylethinyl)cyclohexanol (2), 2-methyl-1-(2-phenylethinyl)cyclohexanol (3), 2-isopropyl-5-methyl-1-(2-phenylethinyl)cyclohexanol (4), 1,7,7,-trimethyl-2-(2-phenylethinyl)bicyclo [2.2.1] heptanol-2 (5) and 2-phenylethinyltricyclo [3,3,1.03,7]nonanol-2 (6). Synthesis reactions of aromatic acetylene alcohols, activation energies were determined, kinetic of chemical changes and reaction mechanisms were proposed. The course of the reactions and the effect of the selected ketone molecule size, structure and …
Ethinylation Reactions Of Some Aldehydes In The Presence Of Phenylacetylene Using High-Base Catalytic Systems, Abdurakhmanova Saida, Ikramov Abduvaxab, Ziyadullayev Odiljon, Ablakulov Lochin
Ethinylation Reactions Of Some Aldehydes In The Presence Of Phenylacetylene Using High-Base Catalytic Systems, Abdurakhmanova Saida, Ikramov Abduvaxab, Ziyadullayev Odiljon, Ablakulov Lochin
CHEMISTRY AND CHEMICAL ENGINEERING
The aim of the research work is the development of synthesis methods of aromatic acetylene alcohols and their various derivatives using different catalytic systems and also, determining their structure, physico-chemical and biological properties. The most effective way of synthesizing AAA is determined using selected complex catalytic systems and also, the range of catalytic activity of used catalysts is created. Acetic aldehyde, benzaldehyde and cyclohexonal, high-base catalytic systems − MOH/ДМСО∙H2O and M2CO3/ДMСO∙H2O with phenylacetylene reaction of enantioselective etynilation were investiged. Efficiency and course of chemical reaction in the process of formation acetylene alcohol affection of temperature, reaction duration, solvents, catalysts and …
Alkinylation Reactions Of Benzaldehyde By Ethynylbenzene In The Presence Of Some Catalysts, Abdurakhmanova Saida, Ziyadullaev Odiljon, Ikramov Abduvakhab, Dobrynkin Nikolay
Alkinylation Reactions Of Benzaldehyde By Ethynylbenzene In The Presence Of Some Catalysts, Abdurakhmanova Saida, Ziyadullaev Odiljon, Ikramov Abduvakhab, Dobrynkin Nikolay
CHEMISTRY AND CHEMICAL ENGINEERING
The synthesis of acetylene alcohol 1,3-diphenyl propin-2-ol-1, which has several reaction centers in the molecule, is studied. This product was obtained for the first time from a representative of aromatic hydrocarbons of benzaldehyde with phenylacetylene based on an alkynylation reaction in the presence of stereoselective catalysts - ZnEt2/Ti(OiPr)4/PhMe and Sn(OTf)2/NEt3/MeCN. The influence of the activity, stability, and selectivity of the selected catalysts on the yield of products, as well as, the rate of the main reactions, along with side reactions was analyzed. The optimal conditions for the alkynylation reaction and the selectivity of the process are determined. The main and …