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Full-Text Articles in Engineering

Riki&Dolphin: Real Time Data Transmission From The Bottom Of A Cave To A Website, Luca Tringali, Giacomo Canciani Dr., Tecla Tripari, Alexander Debenjak, Caterina Bearzotti May 2026

Riki&Dolphin: Real Time Data Transmission From The Bottom Of A Cave To A Website, Luca Tringali, Giacomo Canciani Dr., Tecla Tripari, Alexander Debenjak, Caterina Bearzotti

International Journal of Speleology

Coming from over 10 years of experience in cave monitoring in northeast Italy, Gruppo Speleologico Talpe del Carso, has designed Riki and Dolphin: customizable, low cost, and easy to assemble tools for getting real time data transmission from the bottom of a cave, even underwater, to a webserver. Their use has been tested to monitor air temperature inside the Abisso Bonetti Cave (Classical Karst, Italy), proving for the first time that a cave in Gorizian Karst can systematically be colder than the outdoor temperature even in winter, recording an internal temperature even lower than 0°C. The Dolphin device can be …


Mosquito Classification And Explainability From Image Data Via Deep Learning Techniques, Farhat Binte Azam Oct 2025

Mosquito Classification And Explainability From Image Data Via Deep Learning Techniques, Farhat Binte Azam

USF Tampa Graduate Theses and Dissertations

According to the World Health Organization (WHO), mosquitoes are the deadliest animals on Earth, responsible for more human deaths annually than any other species. Mosquito-borne illnesses continue to pose severe risks to global health. In 2015 alone, there were an estimated 214 million malaria cases worldwide. Similarly, a 2016 report from the Centers for Disease Control and Prevention (CDC) revealed that Puerto Rico’s Department of Health received over 62,500 suspected cases of Zika, with 29,345 confirmed positive cases. In 2019, Southeast Asia experienced its worst dengue outbreak in recorded history. Of the approximately 4,500 mosquito species distributed across 34 genera, …


Understanding Russia’S Cyber Policies, Strategies, And Doctrines, Bryan Hancock, Hanh Nguyen, Olga Karpoyan, Ekzhin Ear, Shouhuai Xu Jun 2025

Understanding Russia’S Cyber Policies, Strategies, And Doctrines, Bryan Hancock, Hanh Nguyen, Olga Karpoyan, Ekzhin Ear, Shouhuai Xu

Military Cyber Affairs

This study analyzes the strengths and weaknesses of Russia’s cyber policies, strategies, and doctrines through a systematic set of attributes, leading to key insights: (i) Russia has proactively adapted its cyber policies, strategies, and doctrines to its evolving environment; (ii) Russia actively conducts cognitive warfare, but remains equally vulnerable to it; and (iii) Russia’s cyber posture faces significant challenges, including a limited technological base, shortage of skilled personnel, and restrictive approach to information control, all of which undermine the effectiveness of its strategies. These insights offer valuable implications for US Cyber Command and the Department of Defense.


The Newgeneratortm Decentralized Wastewater Treatment System For Non-Sewered Sanitation: Technology Advancement Through Field Evaluation And Modeling, Hsiang-Yang Shyu Jul 2024

The Newgeneratortm Decentralized Wastewater Treatment System For Non-Sewered Sanitation: Technology Advancement Through Field Evaluation And Modeling, Hsiang-Yang Shyu

USF Tampa Graduate Theses and Dissertations

Non-sewered sanitation systems (NSSS) offer innovative solutions to sanitation challenges in areas lacking basic facilities, utilizing advanced treatment technologies for on-site water reuse. The NEWgenerator (NG), an advanced NSSS developed at the University of South Florida under the Bill & Melinda Gates Foundation’s Reinventing the Toilet Challenge, integrates an anaerobic membrane bioreactor (AnMBR), an ion exchange-based nutrient capture system (NCS), and an electrochlorinator for final disinfection. This study builds on previous field trials of the NG system, focusing on developing, evaluating, and optimizing its water reuse capabilities through field trials, system dynamics modeling, and advanced monitoring techniques.

In the first …


Assessing The Social, Economic, And Environmental Impacts Of A Multifunctional Crop: The Case Of Moringa Oleifera, Yoel Gebrai Jun 2024

Assessing The Social, Economic, And Environmental Impacts Of A Multifunctional Crop: The Case Of Moringa Oleifera, Yoel Gebrai

USF Tampa Graduate Theses and Dissertations

Multifunctional crops have the potential to support societal goals toward more sustainable production of food, feed, and fuel. The production and processing of multifunctional crops, with their numerous uses and coproducts, is accompanied by social, economic, and environmental impacts that need to be systematically evaluated to avoid unintended consequences from widespread adoption. Complexity emerges in the presence of multifunctionality, and counterintuitive system responses can occur. As a result, this dissertation has sought to enhance and apply frameworks to assess multifunctional crop sustainability holistically. Systems thinking and life cycle approaches are applied to a multifunctional crop case study, Moringa oleifera (MO). …


Modeling Studies Of An Intensified Reforming/Fischer-Tropsch Synthesis Process For Gas To Liquid Conversion, Brian Gray Mar 2024

Modeling Studies Of An Intensified Reforming/Fischer-Tropsch Synthesis Process For Gas To Liquid Conversion, Brian Gray

USF Tampa Graduate Theses and Dissertations

Despite rigorous study and advancement in fields of green energy, the world's transportation industry remains poised to continue reliance on liquid hydrocarbon fuels. To date, the primary source of diesel and jet fuels is the petroleum industry; however, continuing trends in rising greenhouse gas emissions present a need for study into processes for the production of synthetic hydrocarbon fuels. The most promising technologies to meet this goal are gas-to-liquid (GtL), biomass-to-liquid (BtL) and coal-to-liquid (CtL). The commonality of these technologies is that they utilize a feedstock to produce carbon monoxide and hydrogen gas (syngas) which becomes the building blocks of …


Leveraging Systems Thinking For Global Environmental Health, Martha M. Mcalister Mar 2024

Leveraging Systems Thinking For Global Environmental Health, Martha M. Mcalister

USF Tampa Graduate Theses and Dissertations

Environmental health inequities such as household air pollution, inadequate water, sanitation, and hygiene, and chemical pollution persist globally and have myriad consequences on individual and societal well-being. Unfortunately, while billions of dollars and countless hours of research have been applied towards addressing these issues in development, humanitarian, and environmental justice contexts, attempts to reduce the environmental burden of disease can seem successful at first, but then backslide to pre-intervention conditions (or worse). This is indicative of policy resistance, a tendency of complex systems that makes it very difficult to enact change if the “rules” of the system are misunderstood. There …


Development Of A Suspended Aerobic Membrane Bioreactor (Sambr) For Sustainable Wastewater Treatment On Early Planetary Bases, Talon James Bullard Jan 2024

Development Of A Suspended Aerobic Membrane Bioreactor (Sambr) For Sustainable Wastewater Treatment On Early Planetary Bases, Talon James Bullard

USF Tampa Graduate Theses and Dissertations

Environmental Control and Life Support Systems (ECLSS) ideally should treat all “waste” streams for recovery in a sustainable and near closed-loop manner. This will be critical for Partial Gravity Habitats (PGH) and Early Planetary Bases (EPB) that will be established on the Moon and Mars due to the lack of readily available resources. Currently, the Water Recovery System (WRS), onboard the International Space Station (ISS), recovers and purifies water from urine and graywater. While efficient, this system is not optimized for future missions and utilizes physical-chemical technologies that operate with single-use and hazardous consumables. In response to the lack of …


Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque Jul 2023

Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque

USF Tampa Graduate Theses and Dissertations

The effective management of nutrients, such as nitrogen and phosphorus, in decentralizedwastewater treatment environments is a pressing challenge. These nutrients pose significant risks to the environment and public health when discharged into water bodies, while their recovery and reuse can help alleviate nutrient shortages in various industries, including agriculture. Conventional biological treatment methods used in centralized facilities are not suitable for decentralized systems due to operational complexities and space limitations. Chemical treatment mechanisms, such as adsorption, ion exchange, precipitation, and air-stripping, offer potential solutions but are accompanied by challenges like high costs and logistical issues. Therefore, finding a sustainable and …


Insect Classification And Explainability From Image Data Via Deep Learning Techniques, Tanvir Hossain Bhuiyan Jun 2023

Insect Classification And Explainability From Image Data Via Deep Learning Techniques, Tanvir Hossain Bhuiyan

USF Tampa Graduate Theses and Dissertations

Since the dawn of the Industrial Revolution, humanity has always tried to make labor more efficient and automated, and this trend is only continuing in the modern digital age. With the advent of artificial intelligence (AI) techniques in the latter part of the 20th century, the speed and scale with which AI has been leveraged to automate tasks defy human imagination. Many people deeply entrenched in the technology field are genuinely intrigued and concerned about how AI may change many of the ways in which humans have been living for millennia. Only time will provide the answers. This dissertation is …


Assessment And Prevention Of Bacterial Regrowth In Stored Household Water In Eastern Coastal Madagascar, Lauren Judah Oct 2022

Assessment And Prevention Of Bacterial Regrowth In Stored Household Water In Eastern Coastal Madagascar, Lauren Judah

USF Tampa Graduate Theses and Dissertations

As of 2020, diarrheal diseases were the leading cause of death in Madagascar. A major cause of diarrheal illness is contaminated water, and one crucial aspect of preventing contaminated water is safe household storage. Bacterial regrowth between point-of-collection and household storage has been well established in literature. A frequently implicated source of regrowth is the storage container’s biofilm, which is a community of varying bacteria enclosed in a “slimy” extracellular polymeric substance that forms on surfaces in wet environments and anchors bacteria to those surfaces. The overall goal of this thesis was to quantify and control bacterial regrowth in household …


A Convergent Approach To Aqueous Lead (Pb) Mitigation Of A Supplemental Self-Supply Shallow Groundwater Source Accessed By Handpumps In Madagascar, Adaline Marie Buerck Jun 2022

A Convergent Approach To Aqueous Lead (Pb) Mitigation Of A Supplemental Self-Supply Shallow Groundwater Source Accessed By Handpumps In Madagascar, Adaline Marie Buerck

USF Tampa Graduate Theses and Dissertations

The World Health Organization (WHO) has consistently listed lead (Pb) as one of the ten chemicals of major public health concern. Though the toxic nature of lead has been known since the 20th century it is still utilized in a wide variety of products due to its favorable properties. Exposure to lead still accounts for approximately 900,000 deaths annually and disproportionately impacts those in low- and middle-income countries (LMIC) due to a variety of reasons such as poverty, malnutrition, and lack of knowledge on the toxic nature of lead. Lead exposure routes include air, soil, dust, diet, and water. Though …


Evaluation Of Aluminum Dissolution, Current Density, And Pitting Patterns During Electrocoagulation, Monica Castro Carias Jun 2022

Evaluation Of Aluminum Dissolution, Current Density, And Pitting Patterns During Electrocoagulation, Monica Castro Carias

USF Tampa Graduate Theses and Dissertations

Electrocoagulation (EC) is a sustainable water treatment process involving the generation of coagulants on-site through the application of a voltage on metal (usually aluminum or iron alloys). The factors that impact EC system performance have been well researched, however further research is needed on the factors that impact anodic dissolution of aluminum electrodes, especially when the technology is transferred to full-scale applications. Electrode fouling is one of the factors that can impact dissolution of the anode during EC due to the formation of a protective oxide/hydroxide layer on the electrode surface. Previous studies have addressed electrode fouling by reversing polarity, …


Development Of Membrane Assisted Recovery Of Solids (Mars) Technology For Nutrient Management In Decentralized Wastewater Treatment Systems, Itzé Alejandra Kenney Mar 2022

Development Of Membrane Assisted Recovery Of Solids (Mars) Technology For Nutrient Management In Decentralized Wastewater Treatment Systems, Itzé Alejandra Kenney

USF Tampa Graduate Theses and Dissertations

Increasing global populations will result in a rise of eutrophic wastewater and an increased need in food supply. Both problems share a commonality: nutrients. Not all communities are equipped to handle one or both of those challenges, considering that typical solutions require large and energy intensive technologies. Wastewater treatment in most major cities is done through centralized treatment plants, which is not feasible for places with limited resources. Decentralized wastewater treatment systems (DWTS) have been developed as an alternative solution for those communities, but they still struggle to sustainably treat nutrients such as ammonium (NH4) and phosphate (PO4^(3-)). Zeolite has …


Pressure Retarded Osmosis: A Potential Technology For Seawater Desalination Energy Recovery And Concentrate Management, Joshua Benjamin Nov 2021

Pressure Retarded Osmosis: A Potential Technology For Seawater Desalination Energy Recovery And Concentrate Management, Joshua Benjamin

USF Tampa Graduate Theses and Dissertations

Currently, a significant challenge with reverse osmosis-based desalination is reducing the energy consumption and environmental impacts of the process. This project analyzed the viability of using pressure-retarded osmosis (PRO) for energy recovery in seawater desalination facilities using brine concentrate (the draw solution) and other water sources (the feed solution) such as wastewater effluent. The primary goal of this project is to decrease the cost and overall energy consumption of seawater desalination through PRO-based energy recovery. Process modeling, statistical and sensitivity analysis, energy and cost analysis, geospatial and GIS analysis, laboratory-scale testing, water quality analysis, SEM-EDS microscopy, computational fluid dynamics (CFD), …


Sanitation Marketing In Uganda: The Impact Of Gender On Participation And Outcomes, Elizabeth Vicario Oct 2021

Sanitation Marketing In Uganda: The Impact Of Gender On Participation And Outcomes, Elizabeth Vicario

USF Tampa Graduate Theses and Dissertations

Uganda aims to reach universal access to basic sanitation under Sustainable Development Goal #6, but achieving this target by 2030 would require doubling the annual rate of progress. Women are disproportionately affected by poor sanitation due to their health needs and risk of facing violence, but they have historically been excluded from sanitation planning. Low household demand and poor service delivery have stalled progress in Uganda. Market-based sanitation (MBS) is a novel method of developing a sanitation market through stimulating demand and supporting a competitive atmosphere for product and service providers. This research studies the sanitation marketing activities implemented by …


Community Assessment Of Water Perceptions And Household Point-Of-Use Treatment Methods In Madagascar, Isabella Rose Silverman Oct 2021

Community Assessment Of Water Perceptions And Household Point-Of-Use Treatment Methods In Madagascar, Isabella Rose Silverman

USF Tampa Graduate Theses and Dissertations

One in four people around the world do not have access to safe drinking water, which means that two billion people globally lack access. In high-income countries, 0.02% of yearly deaths are attributed to unsafe water sources; however, an alarming 10.6% of deaths occur in Madagascar, for the same reason.

To achieve Sustainable Development Goal 6: Ensure access to water and sanitation for all, a collaboration between public health and engineering is critical. Within the public health sector, social marketing is commonly utilized to address a problem by using commercial marketing principles to change behavior for the good of society. …


Laboratory Examination Of Lead Weights Harvested From Pitcher Pumps In Eastern Madagascar, Madelyn Wilson Oct 2021

Laboratory Examination Of Lead Weights Harvested From Pitcher Pumps In Eastern Madagascar, Madelyn Wilson

USF Tampa Graduate Theses and Dissertations

Previous sampling campaigns in Tamatave, Madagascar, conducted by the University of South Florida (USF) have identified lead contamination in drinking water sourced from self-supply pitcher pumps. The pitcher pump piston and foot valves were identified as the primary source of lead contamination since they are often manufactured from recycled lead acid batteries. The previous field sampling technique consisted of collecting an aliquot of a 10-15-liter composite sample from the pitcher pump for dissolved lead analysis; however, this technique (1) neglects the contribution of particulate lead, (2) does not properly account for the effects of water stagnation inside the pitcher pump …


Water Regulation For Enhancing Soil Quality Using Cactus Mucilage: A Theoretical And Experimental Analysis, Khuloud Alrashdi Jul 2021

Water Regulation For Enhancing Soil Quality Using Cactus Mucilage: A Theoretical And Experimental Analysis, Khuloud Alrashdi

USF Tampa Graduate Theses and Dissertations

As water is one of the primary sources of life, it is essential in an endless number of systems and processes to be utilized efficiently in nature and in practical applications. One of these applications includes farming, which depletes a lot of water as the water irrigation systems cover large soil areas. While water is a critical factor in growing crops, a question here stands, can the irrigation process be transformed? This is the overarching goal of my work since it is centered on studying if cactus mucilage, a natural substance, is capable of improving water absorption processes on crops …


Leaf Cutter Ant Nest Soil Cement Stabilized Earthen Bricks: Materials And Methods For Engineering Field Applications, Faith Malay Jun 2021

Leaf Cutter Ant Nest Soil Cement Stabilized Earthen Bricks: Materials And Methods For Engineering Field Applications, Faith Malay

USF Tampa Graduate Theses and Dissertations

As climate change threatens vulnerable tropical climates and development outpaces resource availability, the need for diverse construction material grows. The United Nations Sustainable Development Goals aim to reduce poverty in all forms. Diversifying construction material works toward reducing indoor air pollution, the eradication of houselessness, encouraging diversification in industry, and supporting small scale industrialization. In the Province of Bocas del Toro in Panama, there is a tenuous connection to the greater industries in the country due to location and existing infrastructure.This research presents a literature review of the historical approaches to the construction and chemistry of cement stabilized earth bricks, …


Assessment Of The Environmental Sustainability Of A Small Water Production Facility In Madagascar, Jesal Patel Mar 2021

Assessment Of The Environmental Sustainability Of A Small Water Production Facility In Madagascar, Jesal Patel

USF Tampa Graduate Theses and Dissertations

Nearly 2.2 billion people around the globe struggle with access to safely managed drinking water (WHO/UNICEF, 2019), however, there have been certain initiatives taken, particularly by means of small water production facilities for enhancing access to basic drinking water services in rural areas. The water production facility, specifically located in the low- and middle-income countries, usually encounter operational difficulties as a result of limited availability of resources and are required to depend on other resourceful countries for goods and services. Although, with limited research done for assessing the environmental sustainability of water facilities in low- and middle-income countries, numerous data …


Understanding The Leaching Mechanism For Lead (Pb) Found In Components Of Locally Manufactured Handpumps In Eastern Madagascar, Nidhi Shah Mar 2021

Understanding The Leaching Mechanism For Lead (Pb) Found In Components Of Locally Manufactured Handpumps In Eastern Madagascar, Nidhi Shah

USF Tampa Graduate Theses and Dissertations

This research sought to determine the lead leaching mechanism impacted by an inorganic scale observed from lead valve weights of the pitcher pump systems used in Tamatave, Madagascar. Based on previous research, these valve weights are considered to be a major source for high lead levels in pump water consumed by the residents. As a part of the study, Raman Spectroscopy, X-ray Fluorescence Spectroscopy (XRF) and Energy Dispersive Spectroscopy with Scanning Electron Microscope (SEM-EDS) were performed to address the objectives of this research. The pump component samples for the analysis were selected based on the amount and visual characteristics of …


A Systems Approach For Improving The Performance Of Rural Community-Managed Water Systems Using Siasar: Case Studies In Bolivia And Colombia, Rachel A. Cannon Mar 2021

A Systems Approach For Improving The Performance Of Rural Community-Managed Water Systems Using Siasar: Case Studies In Bolivia And Colombia, Rachel A. Cannon

USF Tampa Graduate Theses and Dissertations

Globally, the focus of environmental engineers and water, sanitation, and hygiene (WASH) professionals in the rural water sector has shifted from building new technology to ensuring long-term functionality of water systems and closing the access gap between urban and rural residents. In Latin America and the Caribbean, the main challenges to ensuring clean water for all rural residents is poor service delivery quality and limited sustainability over time. A common management strategy in the region, and globally, is community-management, where community members manage, operate, and maintain the water system through cost sharing and financial management. The failure of community-managed water …


A Framework For Assessing The Reliability, Availability, Maintainability, And Safety (Rams) Of Decentralized Sanitation, Adefunké Adeosun Nov 2020

A Framework For Assessing The Reliability, Availability, Maintainability, And Safety (Rams) Of Decentralized Sanitation, Adefunké Adeosun

USF Tampa Graduate Theses and Dissertations

In established industry sectors, Reliability, Availability, Maintainability, and Safety (RAMS) risk assessments are normally used to compare the risks associated with different technologies on process units. Sanitation solutions are split into traditional wastewater treatment which is centralized treatment and can be classified as an established industry, and decentralized treatment such as pit latrines and septic tank systems which are on much smaller scales. Also they can be classified as non-conventional methods such as reinvented advanced decentralized non-sewered sanitation solution techniques exist mainly in two forms as “Single-User Reinvented Toilet (SURT)” systems or “Multiple-User Reinvented Toilet (MURT)” systems. Advanced decentralized non-sewered …


Use Of Sugarcane Bagasse Ash As Partial Cement Replacement In Interlocking Stabilized Soil Blocks (Issbs), Adah Shair Oct 2020

Use Of Sugarcane Bagasse Ash As Partial Cement Replacement In Interlocking Stabilized Soil Blocks (Issbs), Adah Shair

USF Tampa Graduate Theses and Dissertations

Global infrastructure needs for adequate housing, water provision and improved sanitation are on the rise. UN-Water estimates that 1 in 3 people still lack access to safe drinking water and about 4.2 billion people across the globe lack access to safely managed sanitation services. Rapid urbanization and the global refugee crisis have also increased the demand for adequate and efficient housing. UN Sustainable Development Goals cannot be achieved until these needs are met. Given the high environmental impact and cost of cement-heavy construction, alternate construction techniques like appropriate earth technologies need to be adopted. Interlocking stabilized soil blocks (ISSBs), a …


Development Of An Integrated Direct Membrane Filtration (Dmf) And Anaerobic Membrane Bioreactor (Anmbr) System For Dilute Municipal Wastewater Treatment, Ahmet Erkan Uman Jul 2020

Development Of An Integrated Direct Membrane Filtration (Dmf) And Anaerobic Membrane Bioreactor (Anmbr) System For Dilute Municipal Wastewater Treatment, Ahmet Erkan Uman

USF Tampa Graduate Theses and Dissertations

The total electricity consumption due to municipal wastewater treatment in the US accounts for 1.3% of total demand. Also, a significant portion of biodegradable constituents in wastewater is converted into biomass, which needs further processing. On the one hand, an excessive amount of energy and chemicals are being used to treat wastewater, but on the other hand, resources (such as nitrogen and phosphorus, energy, and water) in wastewater are being discharged or removed rather than recovered. From this perspective, new wastewater treatment technologies are sorely needed to facilitate resource recovery from wastewater for a better, more sustainable future.

Anaerobic membrane …


Socio-Technical Transitions In The Water Sector: Emerging Boundaries For Utility Resilience In Barbados, Wainella N. Isaacs Jul 2020

Socio-Technical Transitions In The Water Sector: Emerging Boundaries For Utility Resilience In Barbados, Wainella N. Isaacs

USF Tampa Graduate Theses and Dissertations

Resilience is gaining popularity in the water sector where it described as contributing to reduced vulnerability to water-related risks and hazards including climate change. Unfortunately, literature in this area, contributed mainly from North America and Europe, is fragmented with a concentration on engineering resilience in water supply infrastructure. The absence of any scholarship on resilience for a small island nation, coupled with the absence of sociological contributors to building resilience in this sector motivated this research.

The goal of this research was to understand and evaluate how resilience is characterized and operationalized in the Barbados water and wastewater infrastructure system, …


Managing Off-Grid Power Use For Solar Fueled Residences With Smart Appliances, Prices-To-Devices And Iot, Donnelle L. January Jun 2020

Managing Off-Grid Power Use For Solar Fueled Residences With Smart Appliances, Prices-To-Devices And Iot, Donnelle L. January

USF Tampa Graduate Theses and Dissertations

Electricity availability has a profound impact in day to day life. Activities such as lighting homes, charging cellphones, and running appliances all depend on electricity use. Around 1 billion people around the world do not have access to electricity, and the majority of these people hail from developing countries in remote areas. Moreover, many of these remote areas lack utility grid access due to the infeasible cost of extending the grid to remote communities. To combat this, various projects on microgrids have been implemented in order to distribute power to these off-grid areas. Nanogrids are defined as “a single domain …


Luciferase Reporter Crc Cell Line For Bioluminescence Imaging In Orthotopic Tumor Model, Pratik Chopade Mar 2020

Luciferase Reporter Crc Cell Line For Bioluminescence Imaging In Orthotopic Tumor Model, Pratik Chopade

USF Tampa Graduate Theses and Dissertations

CRC is the second most common type of cancer in women and the third most common type of cancer in men. It accounts for 9.7% of all cancers in terms of people diagnosed. Measuring the real-time effect of chemotherapeutic drugs has been a major obstacle in developing a tumor model mouse. Tracking the regression of cancer cells after chemotherapy could be an effective way to resolve this issue. Therefore, cancer cells expressing the constitutive luciferase reporter gene can be a potential solution. The biggest advantage of the luciferase (Luc) reporter is that it is detectable at very low concentrations in …


A Micro-Nano Particle System For Sustained Drug Release In Lung Cancer Therapy, Heta N. Jadhav Mar 2020

A Micro-Nano Particle System For Sustained Drug Release In Lung Cancer Therapy, Heta N. Jadhav

USF Tampa Graduate Theses and Dissertations

Lung cancer remains the leading cause of cancer-related mortality in men and women worldwide (National Comprehensive Cancer Network). Hence, developing an effective new therapy to treat lung cancer is under intense investigation. Specifically, the sustained release of a drug in lung tumors is critically important. Previous studies at the USF have shown that telmisartan exhibits synergistic properties when combined with Actinomycin-D for lung cancer treatment. The objective of this study is to develop a novel micro/nano system consisting of lipids and chitosan polymers that would be able to deliver Tel directly to the lungs and release its payloads in a …