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Full-Text Articles in Engineering
Evaluation Of Novel Hemocompatible Surface Coatings For Extracorporeal Life Support: A Biocompatible Alternative To Systemic Anticoagulation, Teryn Rose Roberts
Evaluation Of Novel Hemocompatible Surface Coatings For Extracorporeal Life Support: A Biocompatible Alternative To Systemic Anticoagulation, Teryn Rose Roberts
USF Tampa Graduate Theses and Dissertations
Extracorporeal life support (ECLS) is a class of technologies used to support or replace the function of failing organs. During ECLS, blood is withdrawn from systemic circulation and circulated through an artificial organ or “treatment membrane” that performs the function of the failing organ, prior to return to systemic circulation. While ECLS provides life-saving therapy to wide patient populations from pre-term infants to combat-wounded soldiers, this therapy is limited due to secondary thrombotic and bleeding complications that result from: 1) exposure of blood to the foreign surfaces in the device circuit and 2) administration of anticoagulant drugs to prevent clot …
Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard
Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard
USF Tampa Graduate Theses and Dissertations
Elastin like polypeptides (ELPs) are a class of naturally derived biomaterials that are non-immunogenic, genetically encodable, and biocompatible making them ideal for a variety of biomedical applications, ranging from drug delivery to tissue engineering. Also, ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides and functionalization of ELPs. This work utilizes ELPs for regenerative medicine and drug delivery.
The goal of the first study was to synthesize a biologically active epidermal growth factor-ELP (EGF-ELP) fusion …
Topographical Enhancement Of Cell Adhesion On Poorly Adhesive Materials, Maritza Muniz Maisonet
Topographical Enhancement Of Cell Adhesion On Poorly Adhesive Materials, Maritza Muniz Maisonet
USF Tampa Graduate Theses and Dissertations
The overall thrust of this dissertation is to gain a fundamental understanding of the synergistic effects between surface topography and chemical functionality of poorly adhesive materials on enhancing the adhesion of mouse embryonic fibroblasts. Cellular response to surface topography and chemical functionality have been extensively studied on their own providing valuable information that helps in the design of new and improved biomaterials for tissue engineering applications. However, there is a lack of understanding of the synergistic effect of microscale and nanoscale topography with chemical functionality and the relative impact and contribution of each in modulating cellular behavior. By understanding the …
Sic For Advanced Biological Applications, Joseph Register
Sic For Advanced Biological Applications, Joseph Register
USF Tampa Graduate Theses and Dissertations
Silicon carbide (SiC) has been used for centuries as an industrial abrasive and has been
actively researched since the 1960's as a robust material for power electronic applications.
Despite being the first semiconductor to emit blue light in 1907, it has only recently been
discovered that the material has crucial properties ideal for long-term, implantable biomedical
devices. This is due to the fact that the material offers superior biocompatibility and
hemocompatibility while providing rigid mechanical and chemical stability. In addition, the material
is a wide-bandgap semiconductor that can be used for optoelectronics, light delivery, and optical
sensors, which is the …
Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka
Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka
USF Tampa Graduate Theses and Dissertations
This dissertation has aimed to fabricate polypeptide based biomaterial and characterize physical properties. Electrospinning is used as a tool for the sample fabrication. Project focused on determining the feasibility of electrospinning of certain synthetic polypeptides and certain elastin-like peptides from aqueous feedstocks and to characterize physical properties of polymer aqueous solution, cast film and spun fibers and fiber mats. The research involves peptide design, polymer electrospinning, fibers crosslinking, determining the extent of crosslinking, fibers protease degradation study, fibers stability and self-organization analysis, structure and composition determination by various spectroscopy and microscopy techniques and characterization of mechanical properties of individual suspended …
Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja
Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja
USF Tampa Graduate Theses and Dissertations
Tendons, essential tissues that connect muscles to bones, are susceptible to rupture/degeneration due to their continuous use for enabling movement. Often surgical intervention is required to repair the tendon; relieving the pain and fixing the limited mobility that occurs from the damage. Unfortunately, post-surgery immobilization techniques required to restore tendon properties frequently lead to scar formation and reduced tendon range of motion. Our ultimate goal is to create an optimal tendon prosthetic that can stabilize the damaged muscle-bone connection and then be remodeled by resident cells from the surrounding tissues over time to ensure long-term function. To achieve this, we …