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Transdermal Delivery Of Phosphorodiamidate Morpholino Oligomers Across Hairless Mouse Skin, Angela K. Pannier, Vikram Arora, Patrick L. Iversen, Rhonda M. Brand
Transdermal Delivery Of Phosphorodiamidate Morpholino Oligomers Across Hairless Mouse Skin, Angela K. Pannier, Vikram Arora, Patrick L. Iversen, Rhonda M. Brand
Department of Biological Systems Engineering: Papers and Publications
The skin is the largest organ in the body and an obvious route for both local and systemic drug delivery. Antisense oligomers have tremendous potential as therapeutic agents for numerous diseases. The objective of this study was to investigate the influence of vehicle on the transdermal delivery of several phosphorodiamidate Morpholino oligomers (PMOs) with different sizes, lengths, base compositions, sequences, and lipophilicities. Eleven different PMOs were synthesized complementary to biologically relevant gene targets and delivered across hairless mouse skin in vitro using vehicles composed of 95% propylene glycol, 5% linoleic acid (PG/LA), water, 50% water:50% PG/LA, and 75% water:25% PG/LA. …