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Articles 1 - 14 of 14
Full-Text Articles in Engineering
Chiroptical Second-Harmonic Tyndall Scattering From Silicon Nanohelices, Ben J. Olohan, Emilija Petronijevic, Ufuk Kilic, Shawn Wimer, Matthew Hilfiker, Mathias Schubert, Christos Argyropoulos, Eva Schubert, Samuel R. Clowes, G. Dan Pantoş, David L. Andrews, Ventsislav K. Valev
Chiroptical Second-Harmonic Tyndall Scattering From Silicon Nanohelices, Ben J. Olohan, Emilija Petronijevic, Ufuk Kilic, Shawn Wimer, Matthew Hilfiker, Mathias Schubert, Christos Argyropoulos, Eva Schubert, Samuel R. Clowes, G. Dan Pantoş, David L. Andrews, Ventsislav K. Valev
Department of Electrical and Computer Engineering: Faculty Publications
Chirality is omnipresent in the living world. As biomimetic nanotechnology and self-assembly advance, they too need chirality. Accordingly, there is a pressing need to develop general methods to characterize chiral building blocks at the nanoscale in liquids such as water-the medium of life. Here, we demonstrate the chiroptical second-harmonic Tyndall scattering effect. The effect was observed in Si nanohelices, an example of a high-refractive-index dielectric nanomaterial. For three wavelengths of illumination, we observe a clear difference in the second-harmonic scattered light that depends on the chirality of the nanohelices and the handedness of circularly polarized light. Importantly, we provide a …
Development Of Quantitative Structure Activity Relationships (Qsars) For Predicting The Aggregation Of Tio2 Nanoparticles Under Favorable Conditions, Jaewoong Lee
Department of Civil and Environmental Engineering: Faculty Publications
This study developed multi-linear regression (MLR) quantitative structure-activity relationships (QSARs) to predict n-TiO2 aggregation in the presence of high concentrations of representative emerging organic contaminants (EOCs), which presented favorable conditions to interaction with n-TiO2. The largest diameter change (Δ 517 nm at 0 h and Δ 1164 nm at 12 h) of n-TiO2 was observed by estrone, while the smallest diameter change (Δ -114 nm at 0 h and – 4 nm at 12 h) was observed by lincomycin during experimental periods. In addition, the zeta potential changes of n-TiO2 were …
Understanding The Role Of Antioxidant Nanoparticles In Improving The Outcome Of Secondary Injury In Traumatic Brain Injury, Aria W. Tarudji
Understanding The Role Of Antioxidant Nanoparticles In Improving The Outcome Of Secondary Injury In Traumatic Brain Injury, Aria W. Tarudji
Department of Biological Systems Engineering: Dissertations and Theses
Following traumatic brain injury (TBI), excess reactive oxygen species (ROS) and other free radicals are released, inducing the cascade of secondary injury that exacerbate the outcomes of TBI. Antioxidant nanoparticles (ANPs) have shown promising outcomes in reducing the progression of TBI, which may be due to the higher accumulation and retention of ANPs in the injured brain. However, there is limited knowledge of: 1) antioxidant activities needed in TBI treatment, 2) correlation between longer retention, bioavailability, and target engagement with antioxidant treatments, and 3) sexual dimorphism to ANP treatments.
This dissertation assesses multiple ANPs with various scavenging activities and durations …
Impact Of Particle Surface Charge Heterogeneity On Deposition Onto Flat Surfaces And Transport In Porous Media, Thompson Delon
Impact Of Particle Surface Charge Heterogeneity On Deposition Onto Flat Surfaces And Transport In Porous Media, Thompson Delon
Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research
Biological and non-biological natural colloids are anisotropic and ubiquitously exist in groundwater. Previously in colloid transport modelling, colloids are assumed to be homogenous for simplification, whether in shape or surface charge. More research has been done to incorporate surface heterogeneity in the transport experiment, i.e., surface charge heterogeneity on collector in column experiment. However, few studies have been done on surface heterogeneity on colloids themselves.
In this dissertation, Janus particles with different surface charge was developed to model surface heterogeneity on colloids. The interaction energy between Janus particle and flat surfaces was analyzed through DLVO simulation. It was discovered that …
Synthetic Lethality In Pediatric Brain Cancer Cells By Optimized Plga Nanoparticles And Drug Combinations, Megan Ruckman, Megan Otte, Forrest Kievit
Synthetic Lethality In Pediatric Brain Cancer Cells By Optimized Plga Nanoparticles And Drug Combinations, Megan Ruckman, Megan Otte, Forrest Kievit
UCARE Research Products
Here we test drugs effectiveness to inhibit various DNA repair pathways with the purpose of sensitizing cancer cells to radiotherapy. We work on optimizing delivery of DNA repair pathway inhibiting drugs by the use of PLGA nanoparticles.
Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon Mcdonald, Forrest Kievit
Nanoparticle Treatment To Counter Reactive Oxygen Species After Traumatic Brain Injury, Brandon Mcdonald, Forrest Kievit
UCARE Research Products
Traumatic brain injury (TBI) is defined as damage to the brain, resulting from an external mechanical force, such as an impact to the head (Kievit et. al, 2016).There are several examples that could result in a potential TBI; such as falling with contact to the head, car accidents and even physical activities including football, wrestling, and boxing. Because of the several different scenarios that an individual could impact their head, TBI’s have become an all too common aspect of everyday life. TBI is currently the leading cause of death and disability in children and adults under the age of 45, …
Assessment Of Nanoparticle Accumulation With Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Hunter Miller
Assessment Of Nanoparticle Accumulation With Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Hunter Miller
Department of Biological Systems Engineering: Dissertations and Theses
Nanoparticle (NP)-based therapeutics promise to improve medicine in multiple areas by increasing target engagement. To date, most research has focused on cancer, aiming to increase uptake using the enhanced permeability and retention (EPR) effect. Despite pre-clinical success in proof-of-concept studies, understanding of the fundamental interactions between NP and biological systems that govern outcomes remains incomplete. To realize the potential of NPs for cancer therapeutics, and to expand their application into other diseases, the roles physicochemical properties play in NP uptake must be better understood. Some investigations have been performed into the effects of size and surface charge on uptake into …
Engineering Of Lipid Nanoparticles For Advanced Drug Delivery Applications, Stephen L. Hayward
Engineering Of Lipid Nanoparticles For Advanced Drug Delivery Applications, Stephen L. Hayward
Department of Chemical and Biomolecular Engineering: Dissertations, Theses, and Student Research
‘Nanomedicine’, the application of nanotechnology principles to the field of medicine, has stimulated the development of nano-platforms for next generation drug delivery. By exploiting nanoscale properties of materials to selectively alter intrinsic characteristics of therapeutics, researchers have improved the efficacy and pharmacokinetic profiles for a variety of drug types. Despite preliminary commercial and clinical success, there still remains a need to develop an improved delivery platform that can provide high cargo entrapment, efficient intracellular delivery, evasion of intracellular degradation pathways, and provide cell population specific targeting.
In this study we engineered a nanocarrier system composed of a core bilayer structure …
Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles For Prevention Of Hiv-1 Infection, Abhijit A. Date, Annemarie Shibata, Emily Mcmullen, Krista La Bruzzo, Patrick Bruck, Michael Belshan, You Zhou, Christopher J. Destache
Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles For Prevention Of Hiv-1 Infection, Abhijit A. Date, Annemarie Shibata, Emily Mcmullen, Krista La Bruzzo, Patrick Bruck, Michael Belshan, You Zhou, Christopher J. Destache
Nebraska Center for Biotechnology: Faculty and Staff Publications
The objective of this investigation was to develop and evaluate a nano-microbicide containing a combination of cellulose acetate phthalate (HIV-1 entry inhibitor) and efavirenz (anti-HIV agent) for HIV prophylaxis. Cellulose acetate phthalate-efavirenz combination nanoparticles (CAP-EFV-NPs) were fabricated by the nanoprecipitation method and were characterized for particle size, zeta potential and encapsulation efficiency of efavirenz. CAP-EFV-NPs were incorporated into a thermosensitive gel (CAP-EFV-NP-Gel). CAP-EFV-NPs, CAP-EFV-NP-Gel and efavirenz solution were evaluated for cytotoxicity to HeLa cells and for in vitro short-term (1-day) and long-term (3-day) prophylaxis against HIV-1 infection in TZM-bl cells. CAP-EFV-NPs had size < 100 nm, negative surface charge and encapsulation efficiency of efavirenz was > 98%. CAP-EFV-NPs and CAP-EFV-NP-Gel were significantly less …
Intrinsically Water-Stable Keratin Nanoparticles And Their In Vivo Biodistribution For Targeted Delivery, Helan Xu, Zhen Shi, Narendra Reddy, Yiqi Yang
Intrinsically Water-Stable Keratin Nanoparticles And Their In Vivo Biodistribution For Targeted Delivery, Helan Xu, Zhen Shi, Narendra Reddy, Yiqi Yang
Department of Biological Systems Engineering: Papers and Publications
Highly water-stable nanoparticles of around 70 nm and capable of distributing with high uptake in certain organs of mice were developed from feather keratin. Nanoparticles could provide novel veterinary diagnostics and therapeutics to boost efficiency in identification and treatment of livestock diseases to improve protein supply and ensure safety and quality of food. Nanoparticles could penetrate easily into cells and small capillaries, surpass detection of the immune system, and reach targeted organs because of their nanoscale sizes. Proteins with positive and negative charges and hydrophobic domains enable loading of various types of drugs and, hence, are advantageous over synthetic polymers …
Nd-Fe-B Nanoparticles Through Surfactant Assisted Mechanical Milling And Alloy Design, Jordann M. Bornhoft
Nd-Fe-B Nanoparticles Through Surfactant Assisted Mechanical Milling And Alloy Design, Jordann M. Bornhoft
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Surfactant-assisted mechanical milling has been used to produce discrete nanoparticles of both Nd-Fe-B and Sm-Co amenable for bottom-up production of nanostructured or nanocomposite permanent magnets. However, in Nd-Fe-B the comminution of the material proceeds by transgranular fracture, which influences both the morphology of the nanoparticles and the magnetic properties. This paper utilizes alloy design to alter the fracture behavior from transgranular fracture to intergranular fracture. Nd-rich Nd2Fe14B alloys were produced by melt spinning in an overquenched state. The melt spun ribbons were annealed at 700°C and 800°C to ensure complete crystallization and to form different grain …
Using Laser Scanning Cytometry To Investigate The Transport Of Nano-Scale Particles In Porous Media, Ryan May
Using Laser Scanning Cytometry To Investigate The Transport Of Nano-Scale Particles In Porous Media, Ryan May
Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research
The increased production of nanomaterials in recent years has been unprecedented. Given their potential toxicity, understanding the mechanisms controlling the transport of nanoparticles in the subsurface is important. In this study, a technique was developed for using a Laser Scanning Cytometer (LSC) to visualize and quantify the stable attachment of nano-scale particles. Experiments using three different size particles, 510 nm, 210 nm and 57 nm, in conjunction with a flow cell system containing saturated glass beads under varied injection duration, solution chemistry, Darcy velocity and solids content were performed. A technique for using the LSC data to develop spatial distributions …
Microbial Reduction Of Uranium Under Iron- And Sulfate-Reducing Conditions: Effect Of Amended Goethite On Microbial Community Composition And Dynamics, H.S. Moon, L. Mcguinness, Ravi K. Kukkadapu, A.D. Peacock, John Komlos, L.J. Kerkhof, P.E. Long, Peter R. Jaffe
Microbial Reduction Of Uranium Under Iron- And Sulfate-Reducing Conditions: Effect Of Amended Goethite On Microbial Community Composition And Dynamics, H.S. Moon, L. Mcguinness, Ravi K. Kukkadapu, A.D. Peacock, John Komlos, L.J. Kerkhof, P.E. Long, Peter R. Jaffe
United States Department of Energy: Publications
There is a growing need for a better understanding of the biogeochemical dynamics involved in microbial U(VI) reduction due to an increasing interest in using biostimulation via electron donor addition as a means to remediate uranium contaminated sites. U (VI) reduction has been observed to be maximized during iron-reducing conditions and to decrease upon commencement of sulfate-reducing conditions. There are many unknowns regarding the impact of iron/sulfate biogeochemistry on U(VI) reduction. This includes Fe(III) availability as well as the microbial community changes, including the activity of iron-reducers during the uranium biostimulation period even after sulfate reduction becomes dominant. Column experiments …
Effects From Filtration, Capping Agents, And Presence/Absence Of Food On The Toxicity Of Silver Nanoparticles To Daphnia Magna, H. Joel Allen, Christopher A. Impellitteri, Dana A. Macke, J. Lee Heckman, Helen C. Poynton, James M. Lazorchak, Shekar Govindaswamy, Deborah L. Roose, Mallikarjuna N. Nadagouda
Effects From Filtration, Capping Agents, And Presence/Absence Of Food On The Toxicity Of Silver Nanoparticles To Daphnia Magna, H. Joel Allen, Christopher A. Impellitteri, Dana A. Macke, J. Lee Heckman, Helen C. Poynton, James M. Lazorchak, Shekar Govindaswamy, Deborah L. Roose, Mallikarjuna N. Nadagouda
United States Environmental Protection Agency: Publications
Relatively little is known about the behavior and toxicity of nanoparticles in the environment. Objectives of work presented here include establishing the toxicity of a variety of silver nanoparticles (AgNPs) to Daphnia magna neonates, assessing the applicability of a commonly used bioassay for testing AgNPs, and determining the advantages and disadvantages of multiple characterization techniques for AgNPs in simple aquatic systems. Daphnia magna were exposed to a silver nitrate solution and AgNPs suspensions including commercially available AgNPs (uncoated and coated), and laboratory-synthesized AgNPs (coated with coffee or citrate). The nanoparticle suspensions were analyzed for silver concentration (microwave acid digestions), size …