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The Production And Characterization Of Chitosan Based Microgels Using A Novel Microfluidic Device To Promote Cell Survival, Kaileen Shevchuk
The Production And Characterization Of Chitosan Based Microgels Using A Novel Microfluidic Device To Promote Cell Survival, Kaileen Shevchuk
Williams Honors College, Honors Research Projects
The purpose of this project is to synthesize and characterize perfluorocarbon modified methacrylamide chitosan (MACF) microgels produced with the use of a capillary-based microfluidic device. Since cell survival and development is highly related to particles physical properties, analysis of microgels set out to determine the particle’s physical properties. I hypothesize that the viscosity of the MACF polymer as well as the amount of photo initiator influence the physical properties of synthesized particles and as a result can generate particles with various features for cell culture in terms of shape, size, charge and swelling abilities. This hypothesis was validated through the …
Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine
Synthesis Of Drug Encapsulated Chitosan-Heparin Based Nanoparticles And Release Study, Trent Richwine
Williams Honors College, Honors Research Projects
The main objective of this honor’s project is to encapsulate drugs with different molecular weights inside of chitosan-heparin based nanoparticles (Cs-Hep NPs). Three different drugs with low (NNC), medium (IFN-γ), and large (BSA) molecular weights were chosen in order to compare all types of drugs and how they react with the nanoparticles. Analysis of particle size, zeta potential, and a release study was performed. The release took place over a 168-hour time period and liquid samples were taken throughout. The hypothesis was that the molecular weight of the drug will correlate to the physical properties of the nanoparticles. The results …