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Peristaltic Flow In The Glymphatic System., Francesco Romanò, Vinod Suresh, Peter Galie, James B Grotberg
Peristaltic Flow In The Glymphatic System., Francesco Romanò, Vinod Suresh, Peter Galie, James B Grotberg
Henry M. Rowan College of Engineering Departmental Research
The flow inside the perivascular space (PVS) is modeled using a first-principles approach in order to investigate how the cerebrospinal fluid (CSF) enters the brain through a permeable layer of glial cells. Lubrication theory is employed to deal with the flow in the thin annular gap of the perivascular space between an impermeable artery and the brain tissue. The artery has an imposed peristaltic deformation and the deformable brain tissue is modeled by means of an elastic Hooke's law. The perivascular flow model is solved numerically, discovering that the peristaltic wave induces a steady streaming to/from the brain which strongly …