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Dissolution Kinetics Of Model Api In Molten Polymer Excipients During Batch Processing, Shen Ji
Dissolution Kinetics Of Model Api In Molten Polymer Excipients During Batch Processing, Shen Ji
Theses
In the pharmaceutical industrial application field, hot-melt extrusion (HME) has been recently introduced to develop new solid dosage forms and products. By dissolving the poorly–soluble active pharmaceutical ingredients (API) into water-soluble polymers, the bioavailability of the Class II (with low solubility and high permeability in water) API in Biopharmaceutical Classification System (BCS) could be significantly improved in the body. For readily water-soluble API, HME provides a new approach to produce a controlled release drug system. Hence, pharmaceutical HME is a promising processing method in the pharmaceutical industry.
However, HME has not been widely applied into the pharmaceutical industry. The thermal …