Engineering Commons^™

Challenges Of Permitting Ballast Water Discharges From Commercial Vessels In U.S. Waters, Paul Rodriguez

Theses

On February 5, 2009, the US Environmental Protection Agency (US EPA) issued the Vessel General Permit (VGP), under the Clean Water Act (CWA), for discharges incidental to the normal operation of vessels, including ballast water discharges. This set forth permit requirements for most commercial vessel discharges within 3 nautical miles of U.S. shore. Since it will expire in December 2013, the US EPA recently issued a draft 2013 VGP. One of the significant changes is the proposal of numerical ballast water discharge standards requiring most commercial vessels to install ballast water treatment systems onboard.

The objective of this thesis is …

Gpu Implementation Of Block Transforms, Boyan Zhang

Theses

Traditionally, intensive floating-point computational ability of Graphics Processing Units (GPUs) has been mainly limited for rendering and visualization application by architecture and programming model. However, with increasing programmability and architecture progress, GPUs inherent massively parallel computational ability have become an essential part of today's mainstream general purpose (non-graphical) high performance computing system. It has been widely reported that adapted GPU-based algorithms outperform significantly their CPU counterpart.

The focus of the thesis is to utilize NVIDIA CUDA GPUs to implement orthogonal transforms such as signal dependent Karhunen-Loeve Transform and signal independent Discrete Cosine Transform. GPU architecture and programming model are examined. …

Alterations In Brain Connectivity After Spinal Cord Injury Using Functional Mri, Yamin Ahmed Noor

Theses

Every year, approximately 50 people per million of inhabitants are inflicted by Spinal Cord Injury (SCI). The long-term impairment of the SCI patients has led researchers to investigate different rehabilitation and treatment efforts that require careful observations to be made on reliable markers. Presently, a number of neuropsychological assessments are used for SCI rehabilitation and research purposes. However, there is a need for the discovery of sensitive biomarkers that can be used to characterize SCI. Altered functional connectivity in the brain has been observed in a number of neurological patient populations. Hence, it was hypothesized that such alterations in brain …

Magnetic Targeted Drug Delivery System In Gene Therapy, Weilong Lu

Theses

Drug delivery system is a method to transport the drug of the required amount accurately to the targeted diseased part. Recently, the concept of Magnetic Targeted Drug Delivery System (MTDDS), based upon magnetic particles under the action of an external magnetic field, exhibits considerable potential for a wide range of medical applications. Gene therapy is the insertion of genes into an individual's cells and tissues to treat diseases. As the recombinant virus vector has many limits and problems, more studies turn to the nonvirus vectors, which have transfection efficiency and low cytotoxicity. PLLA(poly(L lactic acid)) can be biodegradable and has …

Magnetic Iron Oxide Nanoparticles: Synthesis, Characteristics, Magnetic Behavior, And Biomedical Applications, Chengyin Fu

Theses

Magnetic iron oxide nanoparticles are attracting increasing attention due to their interesting properties that can be applied in a great number of applications such as catalysis and biomedicine. This thesis focuses on the synthesis, characteristics, and biomedical applications of iron oxide nanoparticles. The two most common iron oxides, including magnetite and maghemite, are discussed in this thesis.

For most of their applications, the magnetic behavior of iron oxide nanoparticles in a fluid is very important, especially, the high gradient magnetic separation of the particles from a nonmagnetic liquid medium, such as blood in the human body. A 2D model, which …

Fmri Assessment Of Ischemic Stroke In Humans, Rui Yuan

Theses

Cerebral ischemia, or brain ischemia is a kind of stroke where the blood flow is insufficient to the metabolic demand of brain. The lack of oxygen supply will directly lead to the death of brain tissue. There are two major injury regions: the infarct and penumbra. Mostly, since the infarct regions became dead tissues rapidly after stroke, there is a tiny possibility to rescue them in time. But penumbra parts are different. Tissues there will be viable for hours after ischemia. Hence, both theoretically and practically, it is possible to salvage those cells in the penumbra region. Diffusion weighted image …

Simulation Of Polymer Solar Cell Characteristics By Amps-1d, Lu Zhang

Theses

Simulation of polymer solar cell characteristics is presented in this study. The solar cells are made of materials such as the following: Poly (3-hexylthiophene): [6, 6]-phenyl C61- butyric acid methylester (P3HT: PCBM) and poly[2,1,3-benzothiadiazole-4,7-diyl[4,4- bis(2-ethylhexyl)-4H-cyclopenta[2,1-b:3,4-b']dithiophene-2,6-diyl]]: [6, 6]-phenyl C₆₁- butyric acid methylester (PCPDTBT: PCBM) are used as active layer materials. Analysis of Microelectronic and Photonic Structures One Dimension (AMPS-1D) is a computer simulation tool for solar cell device characteristics. The first part of this study focuses on the performance and comparison of current-voltage (I-V) simulations of indium oxide (In₂O₃) and tin oxide (SnO₂) …

Three-Dimensional Magnetic Field Sensor In Ibm 0.18Μm Cmos Technology, Gang Wang

Theses

This work presents a compact three-dimensional Magnetic Field Sensor (MFS) designed in standard Complementary Metal-Oxide-Semiconductor (CMOS) technology. A circular Vertical Hall Device (VHD) for horizontal magnetic field detection and a split- drain Horizontal Hall Device (HHD) for the vertical magnetic field detection are integrated to implement the three-dimensional M FS. This merged design has the advantage of smaller area and lower power consumption. The sensitivity of the vertical hall device (ring-shaped magneto-resistor) and the horizontal hall device (Split-Drain Magnetic Field-Effect Transistor (SD-MAGFET)) is estimated as 0.11V/T and 2.88V/T respectively. The vertical direction of the magnetic field detection demonstrates a higher …

High-Performance Matrix Multiplication On Intel And Fgpa Platforms, Gang Li

Theses

Matrix multiplication is at the core of high-performance numerical computation. Software methods of accelerating matrix multiplication fall into two categories. One is based on calculation simplification. The other one is based on increasing the memory access efficiency. Also matrix multiplication can be accelerated using vector processors. In this investigation, various matrix multiplication algorithms and the vector-based hardware acceleration method are analyzed and compared in terms of performance and memory requirements. Results are shown for Intel and Xilinx FPGA platforms. They show that when the CPU is fast, Goto's algorithm runs faster than Strassen's algorithm because the data access speed is …

Hydrodynamic Effects Of An Arch-Shaped Fiber Optic Probe In A Dissolution Testing Apparatus 2, Yiran Zhang

Theses

Dissolution testing is widely used in the pharmaceutical industry to evaluate newly developed drug formulations and as a quality control method to insure that solid dosage forms have consistent dissolution property. Typically, samples are manually drawn from the dissolution vessel prior to analysis. An approach to overcome the limitations of manual sampling consists in the use of sampling probes, such as fiber optic probes, permanently inserted in the dissolution medium and continually sampling the drug concentration in it as the solid dosage form dissolves. Despite their advantages, permanently inserted fiber optic probes can alter the normal fluid flow within the …

Quantifying Prehension In Persons With Stroke Post Rehabilitation, Saumya Sara Puthenveettil

Theses

This study describes the analysis of reaching and grasping abilities of the hemiparetic arm and hand of patients post stroke after a series of interactive virtual reality (VR) simulated training sessions and conventional physical therapy of similar intensity. Six subjects participated in VR training and five subjects in clinical rehabilitation for two weeks. Subjects’ finger joint angles were measured during a kinematic reach to grasp test using CyberGlove® and arm joint angles were measured using the trackSTARTM system prior to training and after training. Downward force applied to the object during grasping was assessed using Nano17TM, a force/torque sensor system …

Moxon Based Rfid Tag Reader And Gps Antenna, Haojiong Liu

Theses

Modern communication applications at UHF frequencies require antennas with wide band, high forward gain, low backward radiation, high cross-polarization, small size and low manufacture cost. The Moxon antenna based on a two element Yagi-Uda antenna over the ground reflector is one of the most favorite antennas for HAM operators which can produce outstanding front to back ratio of radiated power, good match over the desired band and relatively low elevation height.

A sequence of topologies has been proposed from a single vertical element to two vertical elements of the Moxon arms, until the lately patented Broadband Circularly Polarized Moxon Based …

Experimental Evaluation Of Near Infrared Light Penetration Into Neural Tissue, Ujwal Anil Parikh

Theses

Near infrared (NIR) lasers find applications in medicine both for diagnostic and treatment purposes. Penetration depth into the tissue is a critical parameter to be considered in these NIR laser applications. Published data on the optical properties of rodent neural tissue are rare, despite the frequent use of rats as animal models. The aim of this study was to directly measure the light intensity profile inside the rat brain gray matter that is illuminated by an NIR laser beam. The local light intensities were sampled using an optical fiber inserted into the brain. The intensity profile in the axial direction …

Analysis Of Tissue Engineering Strategies For Bone-Related Applications, Timothy Buirkle

Theses

Over the past few decades, tissue engineering approaches have pushed their way to the forefront of biotechnological research and development, serving a wide variety of applications. This research utilizes quantitative methods to analyze the outcome of two bone tissue engineering studies. In an in vivo study, the use of Negative Pressure Wound Therapy (NPWT) in combination with stem cell-loaded scaffolds was investigated for the repair of large bone defects. Quantitative histological analysis was performed by determining both the percentage of cells proliferating (BrdU), as well as cells expressing bone-specific markers of alkaline phosphatase (A L P) in the defect. Total …

Neuralsta: A Software Tool For Neural Stimulation And Recording Applications With A Laser Control, Rimi Sahu

Theses

The subject of this thesis is a software tool created in Matlab ® for neural stimulation and recording of the evoked potentials. The stimulation output can be delivered in electrical units for immediate use for neural stimulation or as a power control signal to a laser. NeuralSTA is designed to generate arbitrary waveforms of stimulation and simultaneously record the neural response while implementing the spike triggered averaging (STA) method, hence the name NeuralSTA. The output (stimulation) signal can be created in monophasic, biphasic or inverted monophasic forms (for laser control applications). Controls for pulse modulation allow shaping of the pulse …

Theoretical Prediction Of Joint Reaction Force In A Dynamic General 3-D Pendulum Tree Model For Human Or Animal Motion, Sucheta Goyal

Theses

Lagrangian dynamics and the method of superfluous coordinates are applied to predict dynamic joint reaction forces in an idealized flexible model of a branched 3-D pendulum tree system. The number of segments and joints on the tree are adjustable as is the branching tree pattern. The segments that comprise the tree are assumed to be one- dimensional rigid rods containing a discrete set of mass points that is both flexible in number and distribution on the tree. The idealized 3-D pendulum tree system is intended to provide a flexible theoretical framework to model and better understand the dynamics of human …

Combustion Dynamics Of Individual Reactive Material Particles, Carlo Francisco Badiola

Theses

Metallic reactive powders are widely used as solid fuels, pyrotechnic materials, and components of enhanced blast explosives. Metals are attractive because of their high combustion enthalpies and temperatures. Quantitative descriptions of the combustion processes and mechanisms for both pure metal and composite particles are also desired for their proper implementation in specific applications. Among reactive metals, Al is used most widely and its combustion has been studied extensively. A recently developed experimental setup using laser-ignited metal powders enabled one to record optical signatures for time-resolved combustion instances for 2-25 µm diameter aluminum particles burning in different atmospheres. Individual particle diameters …

Neural Differentiation Of Pluripotent Stem Cells And Applications To Micropatterned Agarose Hydrogel For Nerve Guidance, Jamila S. Gittens

Theses

Many central nervous system (CNS) disorders are attributable to damaged oligodendrocytes, the cells that form the myelin sheath of axons. An effective source of human oligodendrocytes is crucial, making pluripotent stem cells, such as embryonic stem (ES) cells, an attractive source for nerve tissue repair and regeneration due to their unlimited capacity for self-renewal and their ability to differentiate into all major cell lineages. Bioengineered 3-D hydrogel culture systems have the potential to elucidate mechanisms required for regeneration of CNS cells. The goals of this study are: (1) to investigate the effects of retinoic acid (RA), sonic hedgehog (shh) agonist, …

Single-Carrier Frequency Domain Equalization Using Subband Decomposition For Optical Wireless Communications, Di Mu

Theses

Optical wireless communication is intended to be applied into indoor and visual distance high-rate data transmission, which is complementary to radio frequency communications. There are specific problems and requirements in optical wireless communications compared with radio frequency communications. Single-carrier frequency domain equalization (SCFDE) is a transmission scheme which has been considered as an alternative of orthogonal frequency-division multiplexing (OFDM), because it has most of the advantages of OFDM and avoids the problems of OFDM. Subband decomposition is a multi-resolution signal analysis and synthesis method, using quadrature mirror filter (QMF) bank to convert time-domain signal to frequency-domain subbands. As a time-to-frequency …

Soy Protein-Poly (L-Lactic Acid) Blend Nanofibers For Drug Delivery Of Nardostachys Jatamansi, Swetha Tiwari

Theses

Electrospun nanofibers when nanofi bers are impregnated with drugs play a significant role in drug delivery. Nanomedical approaches to drug delivery focus on developing nanoscale particles or molecules to improve the bioavailab ility of a drug.

Biodegradable nanofibers were developed using Poly (L – lactic acid) and Soy protein for the delivery of an ayurvedic drug, Nardostachys jatamansi. A weighed quantity of powdered drug – Nardostachys Jatamansi was subjected to Soxhlet extraction using water and ethanol in equal quantities. Various blends of the drug extract and soy protein solution are prepared and mixed in Poly (L-lactic acid). Nanofibers of …

Dynamic Friction: Measurement And Results, Yanal Jij

Theses

Friction has been known as a phenomenon since Leonardo da Vinci era. From that time and through the last four centuries, scientists tried to understand this phenomenon in an effort to overcome its undesired side effects which include energy loss, parts wearing, and errors in control systems. Much has been achieved in studying friction and many experiments have been conducted in this field. These experiments resulted in a mounting evidence that friction is a dynamic phenomenon.

This thesis presents an apparatus that measures dynamic friction in linear motion and the results obtained using this apparatus. The apparatus consists of a …

Alendronate Treatment Elicits A Reduction In Fatigue-Life Of Canine Cortical Bone, Joseph Ryan Geissler

Theses

Bone serves contradictory needs; bone must be strong yet light, and stiff yet flexible. At the tissue level bone material withstands cyclic loading without failing by dissipating energy via the formation and accumulation of microdamage. Proper removal of this damage in exchange for fresh tissue is vital to bone maintenance, and is achieved through a remodeling process. Imbalanced remodeling leads to osteoporotic fractures. Bisphosphonate drugs are proven to reduce fracture risk. However, the long-term effects of bisphosphonates on tissue-level properties are unknown. This study characterized the fatigue-life of cortical bone tissue after bisphosphonate treatment with alendronate (Aln). 1 1th ribs …

Preparation Of Different Polyamide Nanofiltration Membranes By Interfacial Polymerization And The Effect Of Post-Polymerization Treatment On Separation Performance, Yu Qin

Theses

Interfacial polymerization (IP) is a powerful technique for fabrication of thin film composite (TFC) membranes. In this study, polyamide nanofiltration (NF) composite membranes ware prepared by interfacial polymerization of polyethylenimine (PEI) or m-phenylene diamine (MPD) with isophthaloyl dichloride (IPD) on the surface of a porous polyethersulfone (PES) support. Concentrations of monomer reactants for this reaction were decided by equivalent weight ratio. A standard IP procedure was applied to successfully coat PES flat films. After preparation, three different post-polymerization treatments were employed and one optimal treatment was proven after membrane testing.

The TFC flat film membranes were characterized by nanofiltration of …

Hydrogen Storage In Pt/Carbon Nanotube Sheets, An-Yu Ma

Theses

Three types of self-assembled carbon nanotube (CNT) sheets, for example, carboxylic functionalized multi-walled CNTs (MWNTs-COOH), pure multi-walled CNTs (MWNTs), and pure single-walled CNTs (SWNTs), were prepared as substrates by ambient environment vacuum filtration of suspensions of the nanotubes. To enhance hydrogen storage on the CNTs, platinum particles were deposited on the three types of CNT sheets using two processes: electrodeposition (ED) using a DC power source and electrochemical deposition under cyclic voltammetry (CV). To verify platinum deposition on the surface of the CNT sheets, a Scanning Electron Microscope (SEM) was used to obtain images, and Energy Dispersive X-ray (EDX) spectroscopy …

Development Of Gis Database For Hayward Fault, Olugbope Maku

Theses

Earthquake activity and its attendant effects on the earth surface have been a major concern for some time now, especially considering their negative effects in loss of human life, property damage including the emotional impact on witnesses. This study focuses on the Hayward Fault, located in the heart of population center in Contra Costa County of the San Francisco Bay Area, California.

Geographical Information System (GIS) has proved to be a valuable tool in recent years in the study and analysis of earthquakes to complement emergency response efforts. GIS has been adapted to estimate the impact of the geologic hazards …

Development Of 3-D Liver Model For Drug Screening Applications, Divya Rajendran

Theses

The need for a an in vitro drug screening system that mimics the structural organization of natural liver for multi-functionality and maintenance of hepatocytes has become vital in the drug development process. The objective of this study was to engineer a three-dimensional (3-D) liver model using chitosan-based nanofiber scaffolds and co-culture system (adult rat hepatocytes and 3T3-J2 fibroblasts) to mimic the natural liver and to justify its application for in vitro drug screening. Chitosan nanofiber scaffolds were fabricated by electrospinning technique. In order to promote cell adhesion on the chitosan scaffolds, the scaffolds were coated with a cell adhesion molecule, …

The Mechanical Testing Of Single Nanofiber, Pratik Manohar Dahule

Theses

Polymer nanofibers exhibit properties that make them a favorable material for the development of tissue engineering scaffolds, filtration devices, sensors, and high strength lightweight materials. Perfectly aligned PLLA Nanofibers were fabricated by an electrospinning technique under optimum conditions and the diameter of the electrospun fibers can easily be tailored by adjusting the concentration of the polymer solution. To align the nanofibers, special arrangement was made in terms of two aluminum plates. Good alignment of polymer nanofibers on specimen was confirmed by SEM observation. The effect of different electro-spinning parameters on maximum fiber length, average fiber diameter, diameter uniformity, and fiber …

Temperature Elevations Due To Nir Exposure In The Brain Tissue, Ali Ersen

Theses

Near infrared (NIR) lasers have been used in medical applications both for diagnostic and therapeutic purposes. Temperature elevation profile inside the tissue is a critical factor that needs to be better understood in these applications. The purpose of this study is to determine the temperature distribution due to a low power N I R laser irradiation in living neural tissue. Temperature measurements were made directly using a thermocouple probe inside the rat brain cortex within the sagittal plane. The spatial map indicates that N I R light penetrates more readily in the vertical directions than the spreading in the horizontal …

Analysis And Mitigation Of Carrier Frequency Offset For Uplink Of Ofdma, Abhishek R. Panchal

Theses

Orthogonal Frequency Division Multiplexing (OFDM) is being used in many wireless standards because of its immunity to multipath fading, high spectral efficiency and simple implementation, making it suitable for high data rate multimedia wireless applications. One of the significant drawbacks of the OFDM is its sensitivity to Carrier Frequency Offset (CFO). CFO causes Inter Carrier Interference (ICI) between subcarriers and Multiple User Interference (MUI) at Uplink between different users. ICI and MUI at uplink cause significant degradation in the performance of the receiver, therefore, to improve the receiver performance up to acceptable level, compensation of the CFO becomes necessary.

In …