Engineering Commons^™

Optimizing Filter-Probe Diffusion Weighting In The Rat Spinal Cord For Human Translation, Matthew D. Budde, Nathan P. Skinner, L. Tugan Muftuler, Brian D. Schmit, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Rapid In Vivo Detection Of Rat Spinal Cord Injury With Double-Diffusion-Encoded Magnetic Resonance Spectroscopy, Nathan P. Skinner, Shekar N. Kurpad, Brian D. Schmit, L. Tugan Muftuler, Matthew D. Budde

Biomedical Engineering Faculty Research and Publications

Purpose

Diffusion-weighted imaging is a common experimental tool for evaluating spinal cord injury (SCI), yet it suffers from complications that decrease its clinical effectiveness. The most commonly used technique, diffusion tensor imaging (DTI), is often confounded by effects of edema accompanying acute SCI, limiting its sensitivity to the important functional status marker of axonal integrity. The purpose of this study is to introduce a novel diffusion-acquisition method with the goal of overcoming these limitations.

Methods

A double diffusion encoding (DDE) pulse sequence was implemented with a diffusion-weighted filter orthogonal to the spinal cord for suppressing nonneural signals prior to diffusion …

Diffusion Tensor Imaging Correlates With Short-Term Myelopathy Outcome In Patients With Cervical Spondylotic Myelopathy, Aditya Vedantam, Avinash Rao, Shekar N. Kurpad, Michael B. Jirjis, Gerald Eckardt, Brian D. Schmit, Marjorie C. Wang

Biomedical Engineering Faculty Research and Publications

Objective

To determine if spinal cord diffusion tensor imaging indexes correlate with short-term clinical outcome in patients undergoing elective cervical spine surgery for cervical spondylotic myelopathy (CSM).

Methods

A prospective consecutive cohort study was performed in patients undergoing elective cervical spine surgery for CSM. After obtaining informed consent, patients with CSM underwent preoperative T2-weighted magnetic resonance imaging and diffusion tensor imaging of the cervical spine. Fractional anisotropy (FA) values at the level of maximum cord compression and at the noncompressed C1-2 level were calculated on axial images. We recorded the modified Japanese Orthopaedic Association (mJOA) scale, Neck Disability Index, and …