Engineering Commons^™

A Quantitative Tool For Identifying The Epileptogenic Zone Using Network Connectivity Analysis, James Michael Gurisko

Masters Theses

Approximately one-third of patients diagnosed with focal epilepsy do not respond to medication and may be candidates for surgery to remove epileptogenic tissue known as the epileptogenic zone. A detailed pre-surgical evaluation is required and often includes invasive video electroencephalographic monitoring (IVEM) using intracranial surface and depth electrodes, and a camera. The resulting large pools of electrocorticorticographic (ECoG) data are manually analyzed by an expert epileptologist to determine epileptic events. The process is time consuming and prone to human error. This thesis investigates the use of measures to identify the causal relationship between ECoG signals during propagation of a seizure …