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Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications
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Influence Of Γ-Irradiated Biopharmaceutical Films, Samuel Dorey, Fanny Gaston, Magali Barbaroux,, Nathalie Dupuy, Sylvain R.A. Marque
Influence Of Γ-Irradiated Biopharmaceutical Films, Samuel Dorey, Fanny Gaston, Magali Barbaroux,, Nathalie Dupuy, Sylvain R.A. Marque
Single-use Technologies II: Bridging Polymer Science to Biotechnology Applications
Preventing cross-contamination, saving costs and increasing configuration flexibility make the adoption of single-use technologies very attractive for the biopharmaceutical industry. The integrity and the security of bags are due to appropriate flexible and barrier polymeric materials, such as polyethylene (PE) or ethylene vinyl acetate (EVA) and polyethylene-co-vinyl alcohol (EVOH), which are barrier to water vapor and oxygen, respectively. Conventional stainless steel tanks are sterilized by steam sterilization by the end-users, whereas plastic containers are sterilized by gamma-irradiation before delivery. The major advantage of radio-sterilization is the penetration power of the γ-radiation. It is known that γ -sterilization of polyolefin based …