Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Engineering
Anticipating U.S. Population-Level Health And Economic Impacts Using Discrete-Event Simulation To Guide Health Policy Decisions, Odette Reifsnider
Anticipating U.S. Population-Level Health And Economic Impacts Using Discrete-Event Simulation To Guide Health Policy Decisions, Odette Reifsnider
All Dissertations
This dissertation presents two applications of discrete-event simulation (DES) to represent clinical processes: (1) a model to quantify the risk of the maternal obese and diabetic intrauterine environment influence on progression to adult obesity and diabetes, and (2) a model to evaluate health and economic outcomes of different smoking cessation strategies. The first application considers the public health impact of the diabetic and obese intrauterine environment's effect on the prevalence of diabetes and obesity across subsequent generations. We first develop a preliminary DES model to investigate and characterize the epidemiology of diabetes during pregnancy and birth outcomes related to maternal …
Methods Development And Force Field Evaluation For Molecular Simulations Of Interactions Between Structured Peptides And Functionalized Material Surfaces, Galen Collier
All Dissertations
The process of protein adsorption to material surfaces is highly complex and it is one of the most fundamental concepts upon which progress in the field of bioengineering is based. The strategic design of material surfaces for optimal utility in specific biological environments is absolutely dependent upon a thorough understanding of the mechanisms underlying protein adsorption, yet there is still a very limited understanding of these mechanisms. The primary reason for this lack of understanding is that protein adsorption is a dynamic process which occurs at the atomic and macromolecular scale, where experimental analyses provide a view that is static …
Agent-Based Under Hood Packing, Karthik Ravindranath
Agent-Based Under Hood Packing, Karthik Ravindranath
All Theses
Improving vehicle performance and passenger comfort has been a prime engineering concern and focus of research for many years in automotive design. Turning to high-performance components in an effort to improve vehicle performance alone is often not enough and their placement and interactions with other components should also be an integral part of the improvement process. With the advancement in hybrid electric vehicle technology, the packing of components under the hood is ever more essential and challenging. Under hood packing is a multi-objective optimization problem with many, and mostly conflicting objectives. A non-deterministic multi-objective evolutionary algorithm needs to be integrated …