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Articles 1 - 24 of 24
Full-Text Articles in Engineering
Migration And Invasion Of Brain Tumors, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez
Migration And Invasion Of Brain Tumors, Richard A. Able, Jr., Veronica Dudu, Maribel Vazquez
Publications and Research
Recent advances in molecular biology have led to new insights in the development, growth and infiltrative behaviors of primary brain tumors (Demuth and Berens, 2004; Huse and Holland, 2010; Johnson et al., 2009; Kanu et al., 2009). These tumors are derived from various brain cell lineages and have been historically classified on the basis of morphological and, more recently, immunohistochemical features with less emphasis on their underlying molecular pathogenesis (Huse and Holland, 2010). The detailed molecular characterization of brain tumors has laid the groundwork for augmentation of standard treatment with patient-specific designed targeted therapies (Johnson et al., 2009; Kanu et …
Fabrication Of Size-Tunable Metallic Nanoparticles Using Plasmid Dna As A Biomolecular Reactor, Jacopo Samson, Irene Piscopo, Alex Yampolski, Patrick Nahirney, Andrea Parpas, Amit Aggarwal, Raihan Saleh, Charles Michael Drain
Fabrication Of Size-Tunable Metallic Nanoparticles Using Plasmid Dna As A Biomolecular Reactor, Jacopo Samson, Irene Piscopo, Alex Yampolski, Patrick Nahirney, Andrea Parpas, Amit Aggarwal, Raihan Saleh, Charles Michael Drain
Publications and Research
Plasmid DNA can be used as a template to yield gold, palladium, silver, and chromium nanoparticles of different sizes based on variations in incubation time at 70 °C with gold phosphine complexes, with the acetates of silver or palladium, or chromium acetylacetonate. The employment of mild synthetic conditions, minimal procedural steps, and aqueous solvents makes this method environmentally greener and ensures general feasibility. The use of plasmids exploits the capabilities of the biotechnology industry as a source of nanoreactor materials.
Dissemination Of Geological Information In Avoiding Geotechnical Risks Associated With Tunnel Construction: Lessons Learned From Deep Voids In Marble In Lower Manhattan, New York City, Nazrul I. Khandaker, Stanley Schleifer, Masud Ahmed, Leah Scott
Dissemination Of Geological Information In Avoiding Geotechnical Risks Associated With Tunnel Construction: Lessons Learned From Deep Voids In Marble In Lower Manhattan, New York City, Nazrul I. Khandaker, Stanley Schleifer, Masud Ahmed, Leah Scott
Publications and Research
Test boring associated with the recently accomplished City Water Tunnel # 3 in Manhattan, New York City revealed moderately to highly weathered marble with insoluble silicate residues composed mostly of phlogopite, chlorite, and tremolite. Apparent control on the weatherability of the marble was in response to original mineral constituents dominating this lithology. Encountered marble samples ranged between pure calcitic to mixed dolomitic/siliceous types. Fresh marble samples collected from adjacent boring locations revealed characteristic geochemical data: Lime (25-45%), Silica (4-7%), Alumina (1-3%), MgO (5-20%), and LOI (35-42%); compressive strength of unweathered marble varied between 2000-3000 Kg/cm2. Relict foliations with …
Historical Legacies, Information And Contemporary Water Science And Management, Daniel J. Bain, Jennifer A. S. Arrigo, Mark B. Green, Brian A. Pellerin, Charles J. Vörösmarty
Historical Legacies, Information And Contemporary Water Science And Management, Daniel J. Bain, Jennifer A. S. Arrigo, Mark B. Green, Brian A. Pellerin, Charles J. Vörösmarty
Advanced Science Research Center
Hydrologic science has largely built its understanding of the hydrologic cycle using contemporary data sources (i.e., last 100 years). However, as we try to meet water demand over the next 100 years at scales from local to global, we need to expand our scope and embrace other data that address human activities and the alteration of hydrologic systems. For example, the accumulation of human impacts on water systems requires exploration of incompletely documented eras. When examining these historical periods, basic questions relevant to modern systems arise: (1) How is better information incorporated into water management strategies? (2) Does any point …
Bitten By The Science Bug (Nycsef 2011), Maribel Vazquez
Bitten By The Science Bug (Nycsef 2011), Maribel Vazquez
Publications and Research
The invited keynote address to the participants of the final round of the 2011 New York City Science and Engineering Fair (NYCSeF) at the American Museum of Natural History (AMNH).
The Sensitivity Of Land Emissivity Estimates From Amsr-E As C And X Bands To Surface Properties, Hamid Norouzi, Marouane Temimi, William B. Rossow, Cindy Pearl, M. Azarderakhsh, Reza Khanbilvardi
The Sensitivity Of Land Emissivity Estimates From Amsr-E As C And X Bands To Surface Properties, Hamid Norouzi, Marouane Temimi, William B. Rossow, Cindy Pearl, M. Azarderakhsh, Reza Khanbilvardi
Publications and Research
Microwave observations at low frequencies exhibit more sensitivity to surface and subsurface properties with little interference from the atmosphere. The objective of this study is to develop a global land emissivity product using passive microwave observations from the Advanced Microwave Scanning Radiometer – Earth Observing System (AMSR-E) and to investigate its sensitivity to land surface properties. The developed product complements existing land emissivity products from SSM/I and AMSU by adding land emissivity estimates at two lower frequencies, 6.9 and 10.65 GHz (C- and X-band, respectively). Observations at these low frequencies penetrate deeper into the soil layer. Ancillary data used in …
Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang
Transport Of Antibodies And Nanoparticles Across An In Vitro Blood-Brain Barrier, Lin Zhang
Dissertations and Theses
"The blood-brain barrier (BBB) is a dynamic interface between the blood circulation and the central nervous system (CNS). While it serves as a selective barrier to water and solutes to prevent the blood-borne toxins from entering into the brain tissue, it hinders the drug delivery to the CNS for the treatment of brain diseases. Recently therapeutic antibodies and a variety of drug-loaded nanoparticles (NPs) have been widely used to treat CNS disorders such as brain tumors, Alzheimer's disease and Parkinson's disease. To improve brain delivery efficacy of antibodies and NPs, it is necessary to quantify their transport parameters across the …
Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi
Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi
Dissertations and Theses
"Loosening of metal is the leading cause of clinical failures of orthopedic surgeries. A novel coating of self-assembled monolayer of phosphonate molecules (SAMP) that chemically enhances metallic surfaces by covalently bonding to their naturally occurring oxidized surfaces has been developed.1 The SAMP coating is chemically stable, and its in-vitro results showed that it promotes cell proliferation, osteoblast adhesion and enhances biological attachment to metal surfaces.1 The purpose of this study is to establish the efficacy of this novel chemical surface treatment in improving the fixation of metallic implants in both cortical and cancellous bone over a conventional untreated implant. We …
Bias Correction Of Satellite Rainfall Estimation Using A Radar-Gauge Product, Kibrewossen Tesfagiorgis, Shayesteh E. Mahani, Nir Y. Krakauer, Reza Khanbilvardi
Bias Correction Of Satellite Rainfall Estimation Using A Radar-Gauge Product, Kibrewossen Tesfagiorgis, Shayesteh E. Mahani, Nir Y. Krakauer, Reza Khanbilvardi
Publications and Research
Hourly Satellite Precipitation Estimates (SPEs) may be the only available source of information for operational hydrologic and flash flood prediction due to spatial limitations of radar and gauge products. SPEs are prone to larger systematic errors and more uncertainty sources in comparison with ground based radar and gauge precipitation products. The present work develops an approach to seamlessly blend satellite, radar and gauge products to fill gaps in ground-based data. To mix different rainfall products, the bias of any of the products relative to each other should be removed. The study presents and tests a proposed ensemblebased method which aims …
Brooklyn's Thirst, Long Island's Water: Consolidation, Local Control, And The Aquifer, Jeffrey A. Kroessler
Brooklyn's Thirst, Long Island's Water: Consolidation, Local Control, And The Aquifer, Jeffrey A. Kroessler
Publications and Research
The creation of greater New York City in 1898 promised a solution to the problem of supplying Brooklyn and Queens with water. In the 1850s, the City of Brooklyn tapped ponds and streams on the south side of Queens County, and in the 1880s, dug wells for additional supply. This lowered the water table and caused problems for farmers and oystermen, many of whom sued the city for damages. Ultimately, salt water seeped into some wells from over-pumping. By 1896, Brooklyn’s system had reached its limit. Prevented by the state legislature from tapping the aquifer beneath Suffolk’s Pine Barrens, the …
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Bone Tissue Quality Determination Of Mice Through A Novel Reference Point Indentation Technique, Matin Lendhey
Dissertations and Theses
"Bone strength deteriorates with age; which increases the susceptibility to fracture. Current clinical techniques for the estimation of bone strength are largely Bone Mineral Density (BMD) based. However, toughness, which is the ability to resist crack growth, plays a critical role in bones‟ fracture resistance. Traditionally, toughness measurements involve large samples, obviating their use clinically. Recent data suggest that a reference point indentation approach provides a novel, localized measure of toughness from whole bones. In the current research, we evaluated the sensitivity of this method to discriminate small known differences in fracture toughness that exist between inbred mouse strains with …
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Effects Of Estrogen Loss On The Vascular Porosity In Rat Cortical Bone, Jessica D Levy
Dissertations and Theses
"Osteoporosis is a skeletal disease that currently affects 10 million Americans, and is characterized by low bone mass and increased skeletal fragility (National Osteoporosis Foundation, 2011). Estrogen loss, which begins during menopause, is the leading cause of osteoporosis in women. Recent research has focused on changes in cortical bone microporosity due to estrogen loss, which is important for bone health; load-induced interstitial fluid flow within the lacunar-canalicular porosity surrounding osteocytes is thought to play an important role in bone maintenance, while the vascular porosity provides a pressure relaxation mechanism for the fluid flow in the lacunar-canalicular porosity. Recent high-resolution micro-CT …
Impact Of Self-Rewetting Aqueous Solutions On Boiling With Advanced Heat Transfer Applications, Mostafa Morovati
Impact Of Self-Rewetting Aqueous Solutions On Boiling With Advanced Heat Transfer Applications, Mostafa Morovati
Dissertations and Theses
"Pool boiling experiments have been conducted with self-rewetting fluids consisting of aqueous butanol and pentanol solution to study the boiling heat transfer enhancement at pressures of 1 ~ 4 bars. Although self-rewetting fluids have been used to enhance the performance of heat pipes, boiling heat transfer characteristics are yet to be fully understood especially at pressures above atmospheric. Pool boiling experiments with aqueous butanol and pentanol solutions were performed using an electrically heated platinum wire to obtain pool boiling heat transfer data up to the Critical Heat Flux (CHF). Aqueous solutions with butanol concentrations 2-7% showed enhanced heat transfer coefficients …
Flight Control Design For A Tailless Aircraft Using Eigenstructure Assignment, Clara Nieto-Wire, Kenneth Sobel
Flight Control Design For A Tailless Aircraft Using Eigenstructure Assignment, Clara Nieto-Wire, Kenneth Sobel
Publications and Research
We apply eigenstructure assignment to the design of a flight control system for a wind tunnel model of a tailless aircraft. The aircraft, known as the innovative control effectors (ICEs) aircraft, has unconventional control surfaces plus pitch and yaw thrust vectoring. We linearize the aircraft in straight and level flight at an altitude of 15,000 feet and Mach number 0.4. Then, we separately design flight control systems for the longitudinal and lateral dynamics. We use a control allocation scheme with weights so that the lateral pseudoinputs are yaw and roll moment, and the longitudinal pseudoinput is pitching moment. In contrast …
A Multi-Temporal Analysis Of Amsr-E Data For Flood And Discharge Monitoring During The 2008 Flood In Iowa, Marouane Temimi, Teodosio Lacava, Tarendra Lakhankar, Valerio Tramutoli, Hosni Ghedira, Riadh Ata, Reza Khanbilvardi
A Multi-Temporal Analysis Of Amsr-E Data For Flood And Discharge Monitoring During The 2008 Flood In Iowa, Marouane Temimi, Teodosio Lacava, Tarendra Lakhankar, Valerio Tramutoli, Hosni Ghedira, Riadh Ata, Reza Khanbilvardi
Publications and Research
The objective of this work is to demonstrate the potential of using passive microwave data to monitor flood and discharge conditions and to infer watershed hydraulic and hydrologic parameters. The case study is the major flood in Iowa in summer 2008. A new Polarisation Ratio Variation Index (PRVI) was developed based on a multi-temporal analysis of 37 GHz satellite imagery from the Advanced Microwave Scanning Radiometer (AMSR-E) to calculate and detect anomalies in soil moisture and/or inundated areas. The Robust Satellite Technique (RST) which is a change detection approach based on the analysis of historical satellite records was adopted. A …
Diagnosing Water Variations Within The Amazon Basin Using Satellite Data, Marzieh Azarderakhsh, William B. Rossow, Fabrice Papa, Hamidreza Norouzi, Reza Khanbilvardi
Diagnosing Water Variations Within The Amazon Basin Using Satellite Data, Marzieh Azarderakhsh, William B. Rossow, Fabrice Papa, Hamidreza Norouzi, Reza Khanbilvardi
Publications and Research
The components of the Amazon water budget and their spatiotemporal variability are diagnosed using monthly averaged remote sensing‐based data products for the period September 2002‐December 2006. The large Amazon basin is divided into 14 smaller watersheds, and for each of these sub‐basins, fresh water discharge is estimated from the water balance equation using satellite data products. The purpose of this study is to learn how to apply satellite data with global coverage over the large tropical regions; therefore several combinations of remote sensing estimates including total water storage changes, precipitation and evapotranspiration. The results are compared to gauge‐based measurements and …
A Study On The Use Of Inverse Opals Composed Of Zinc Oxide Aggregate Popcorn Particles To Improve The Efficiency Of Dye- Sensitized Solar Cells, Roger Chang
Dissertations and Theses
"In this work, modifications applicable to the working electrode of a dye--‐sensitized solar cell (DSSC) are explored in order to enhance efficiency. Certain compositional and structural changes to the architecture of the electrode are examined. First, the ZnO nanoparticles that are commonly utilized in DSSCs are replaced with ZnO nanoparticle aggregates, also known as ZnO popcorn particles. Subsequently, electrophoretic deposition (EPD) is used to assemble the popcorn particles into an inverse opal structure. This is a unique application of EPD, which has previously been used to infiltrate nanoparticles (d ≤20nm range) Into opal templates, demonstrating the applicability of the technique …
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Dissertations and Theses
This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to grow …
Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc
Proteomic Analysis Of Human Mesenchymal Stem Cell Aging During Serial Sub-Culture, Pawan Kc
Dissertations and Theses
"Human mesenchymal stem cells (hMSCs) hold great potential for clinical applications in regenerative medicine. However, hMSCs occur at a very low frequency in bone marrow so the clinical use as cellular therapeutics requires suitable techniques for isolation and expansion. Furthermore, these cells can be expanded in vitro for only limited passage numbers before they reach a senescent state. Previous studies have shown that long term culture of hMSCs results in the decrease in proliferation rates, changes in genomic expressions, increase in cell sizes, and other morphological changes. Currently the mechanisms of hMSC aging and biomarkers associated with it have not …
Towards A Better Monitoring Of Soil Moisture Using A Combination Of Estimates From Passive Of Microwave And Infrared Observations, Zulamet Z. Vega-Martinez
Towards A Better Monitoring Of Soil Moisture Using A Combination Of Estimates From Passive Of Microwave And Infrared Observations, Zulamet Z. Vega-Martinez
Dissertations and Theses
No abstract provided.
Evaluation Of Quikscat Data For Monitoring Vegetation Phenology, Doralee Pellot
Evaluation Of Quikscat Data For Monitoring Vegetation Phenology, Doralee Pellot
Dissertations and Theses
No abstract provided.
Validation Of Noaa Interactive Snow Maps In The North American Region With National Climatic Data Center Ground-Based Data, Christine Chen
Validation Of Noaa Interactive Snow Maps In The North American Region With National Climatic Data Center Ground-Based Data, Christine Chen
Dissertations and Theses
"Both the areal coverage of snow and the volume of water in its subsequent melt are of concern for the creation and maintenance of both hydroelectric power and local water supply. The interactive multisensor snow and ice mapping system (IMS) is a geographic interactive system that allows for both the viewing of various sensor data and the mapping daily both snow and sea ice extent by an analyst on one platform. This thesis investigates the agreement between the National Oceanic and Atmospheric Administration’s (NOAA) interactive multisensor snow and ice mapping system (IMS) and snow depth values obtained from the National …
High-Resolution Numerical Simulation Of Tidal Enegry Distribution Along The New Jersey Coastline And Influence Of Sea-Level Rise, Simon Kraatz
Dissertations and Theses
No abstract provided.
Adiabatic Air-Water Two Phase Flow Experimental Facilities Design, Construction And Operation, Saman Reshadi
Adiabatic Air-Water Two Phase Flow Experimental Facilities Design, Construction And Operation, Saman Reshadi
Dissertations and Theses
"Experimental studies are conducted to predict the phenomenon(s) and to describe some kind of causation. The design of experiment and the experimental facility is a rigorous method. A well designed, manufactured and operated experimental facility is robust under criticism. Thermal hydraulic characteristics of air-water two-phase flows in a vertical tube (poly-dispersed) and also annulus (mono-dispersed) have been subjected to be studied in detail. The hydrodynamics modeling and simulations need a detailed comparison and verification with experimental results. Obviously, a well-designed experimental facility is required to provide a set of highly accurate and reliable data. To do so, two different research …