Open Access. Powered by Scholars. Published by Universities.®
Journal of Metals, Materials and Minerals
Controlled release; Kinetic; Nanoparticles; Alginate; Chitosan; Curcumin diethyl disuccinate
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Kinetic Study Of Chitosan-Alginate Biopolymeric Nanoparticles For The Controlled Release Of Curcumin Diethyl Disuccinate, S Bhunchu, P Rojsitthisak, P Rojsitthisak
Kinetic Study Of Chitosan-Alginate Biopolymeric Nanoparticles For The Controlled Release Of Curcumin Diethyl Disuccinate, S Bhunchu, P Rojsitthisak, P Rojsitthisak
Journal of Metals, Materials and Minerals
The aim of this study was to investigate the release profile, and evaluate the best fitted kinetic model and mechanism, of curcumin diethyl disuccinate (CDD) from chitosan-alginate biopolymeric nanoparticles (CANPs) in simulated gastrointestinal fluids (without enzymes) and simulated body fluid. The CDD-loaded CANPs (CDD-CANPs) were prepared by oil-in-water emulsification and ionotropic gelation under the previously reported optimal condition (3 mg/mL of CDD, 4.05% (w/v) of TweenTM 80 and a chitosan:alginate mass ratio of 0.05:1), which resulted in CDD-CANPs with a favorable particle size (327±14 nm), zeta potential (-27.3±0.2 mV), encapsulation efficiency (51.2±2.2%) and loading capacity (11.2±0.8%). The in vitro release …