Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Ultrasonic Enhancement Of Antibiotic Action On Gram-Negative Bacteria, William G. Pitt, Michael O. Mcbride, Jared K. Lunceford, Randall J. Roper, Richard D. Sagers
Ultrasonic Enhancement Of Antibiotic Action On Gram-Negative Bacteria, William G. Pitt, Michael O. Mcbride, Jared K. Lunceford, Randall J. Roper, Richard D. Sagers
Faculty Publications
The effect of gentamicin upon planktonic cultures of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, and Staphylococcus aureus was measured with and without application of 67-kHz ultrasonic stimulation. The ultrasound was applied at levels that had no inhibitory or bactericidal activity against the bacteria. Measurements of the MIC and bactericidal activity of gentamicin against planktonic cultures of P. aeruginosa and E. coli demonstrated that simultaneous application of 67-kHz ultrasound enhanced the effectiveness of the antibiotic. A synergistic effect was observed and bacterial viability was reduced several orders of magnitude when gentamicin concentrations and ultrasonic levels which by themselves did not reduce …