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Full-Text Articles in Engineering
Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews
Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews
Theses and Dissertations
This thesis describes the design and basic verification of a discrete event simulator for glucose metabolism in human beings. The simulator implements the glucose metabolism related behavior of various organs in the human body and tracks the blood plasma glucose level as the human body goes through a sequence of diet and exercise events. The simulator can mimic insulin resistance in various organs as well as the loss of insulin production in the pancreas and the adverse impact of these changes on the metabolic behavior of various organs. Thus, the simulator can serve as a model for people with diabetes. …
Industrialization Of Adenoviral Vector Production In Fixed Bed Bioreactor And Amplification Of Primary Liver Cells In Xpansion® Bioreactor: Autologous Insulin Producing Cells For The Treatment Of Diabetes, From Bench To Clinical Scale, Rachel Legmann
Cell Culture Engineering XV
Diabetes is a major global health problem with over 370 million diabetics and an estimated 550 million by 2030. Current therapies rely on recombinant insulin injection to the patients several times a day to control glucose level but do not address the fundamental problem; the loss of insulin producing cells of the pancreas. Orgenesis developed a cell therapy to replace these cells by taking a small biopsy from a patient’s liver, growing the cells in flatware treating these cells with adenovirus vectors containing the genes required to transdifferentiate them to insulin producing cells. This approach allows the diabetic patient to …
Design And Implementation Of An Integrated Biosensor Platform For Lab-On-A-Chip Diabetic Care Systems, Khandaker Abdullah Al Mamun
Design And Implementation Of An Integrated Biosensor Platform For Lab-On-A-Chip Diabetic Care Systems, Khandaker Abdullah Al Mamun
Doctoral Dissertations
Recent advances in semiconductor processing and microfabrication techniques allow the implementation of complex microstructures in a single platform or lab on chip. These devices require fewer samples, allow lightweight implementation, and offer high sensitivities. However, the use of these microstructures place stringent performance constraints on sensor readout architecture. In glucose sensing for diabetic patients, portable handheld devices are common, and have demonstrated significant performance improvement over the last decade. Fluctuations in glucose levels with patient physiological conditions are highly unpredictable and glucose monitors often require complex control algorithms along with dynamic physiological data. Recent research has focused on long term …
Emergency Glucagon Injection Device, John Corbett, Zachary Cullingsworth, Christopher Ducic, Ryan Meekins
Emergency Glucagon Injection Device, John Corbett, Zachary Cullingsworth, Christopher Ducic, Ryan Meekins
Capstone Design Expo Posters
Glucagon is a drug administered to people with diabetes that are experiencing a seizure due to low blood glucose levels. The current method of injecting glucagon during a hypoglycemic seizure is lengthy and complicated when time equates to minimizing the effects of an emergency situation. This project is student created and the result of the design team recognizing a serious problem and deciding to find a better solution. The goal of this project was to streamline this process. Several working prototypes were developed and evaluated before a final design was chosen. Safety, durability and usability were all considerable factors. The …