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Full-Text Articles in Engineering
Physio-Chemical Modifications To Re-Engineer Small Extracellular Vesicles For Targeted Anticancer Therapeutics Delivery And Imaging, Rahmat Asfiya, Lei Xu, Anjugam Paramanantham, Kuanysh Kabytaev, Anna Chernatynskaya, Grace Mccully, Hu Yang, Akhil Srivastava
Physio-Chemical Modifications To Re-Engineer Small Extracellular Vesicles For Targeted Anticancer Therapeutics Delivery And Imaging, Rahmat Asfiya, Lei Xu, Anjugam Paramanantham, Kuanysh Kabytaev, Anna Chernatynskaya, Grace Mccully, Hu Yang, Akhil Srivastava
Chemical and Biochemical Engineering Faculty Research & Creative Works
Cancer theranostics developed through nanoengineering applications are essential for targeted oncologic interventions in the new era of personalized and precision medicine. Recently, small extracellular vesicles (sEVs) have emerged as an attractive nanoengineering platform for tumor-directed anticancer therapeutic delivery and imaging of malignant tumors. These natural nanoparticles have multiple advantages over synthetic nanoparticle-based delivery systems, such as intrinsic targeting ability, less immunogenicity, and a prolonged circulation time. Since the inception of sEVs as a viable replacement for liposomes (synthetic nanoparticles) as a drug delivery vehicle, many studies have attempted to further the therapeutic efficacy of sEVs. This article discusses engineering strategies …
Identifying Sick Cells From High-Resolution Solid-State Micropore Data, Abdul Hafeez, Azhar Ilyas, Ali R. Butt, Samir M. Iqbal
Identifying Sick Cells From High-Resolution Solid-State Micropore Data, Abdul Hafeez, Azhar Ilyas, Ali R. Butt, Samir M. Iqbal
Mechanical Engineering Faculty Publications and Presentations
Early detection of diseases such as cancer can drastically improve prognosis and treatment. To this end, solid-state micropores can measure distinct mechanical properties of diseased cells from their translocation behavior — detected as pulses in the temporal data stream of ionic current — and help diagnose diseases at early stages. However, the obstacle in such approaches is that the accuracy of the sensor is affected by noise, making the pulse detection task too subjective. This is inefficient especially when the disease-relevant data is only a fraction of the total acquired data. Thus, it is important to intelligently automate the detection …
Effect Of Resin Bleed Out On Compaction Behavior Of The Fiber Tow Gap Region During Automated Fiber Placement Manufacturing, Von Clyde Jamora, Virginia Rauch, Sergii G. Kravchenko, Oleksandr G. Kravchenko
Effect Of Resin Bleed Out On Compaction Behavior Of The Fiber Tow Gap Region During Automated Fiber Placement Manufacturing, Von Clyde Jamora, Virginia Rauch, Sergii G. Kravchenko, Oleksandr G. Kravchenko
Mechanical & Aerospace Engineering Faculty Publications
Automated fiber placement is a state-of-the-art manufacturing method which allows for precise control over layup design. However, AFP results in irregular morphology due to fiber tow deposition induced features such as tow gaps and overlaps. Factors such as the squeeze flow and resin bleed out, combined with large non-linear deformation, lead to morphological variability. To understand these complex interacting phenomena, a coupled multiphysics finite element framework was developed to simulate the compaction behavior around fiber tow gap regions, which consists of coupled chemo-rheological and flow-compaction analysis. The compaction analysis incorporated a visco-hyperelastic constitutive model with anisotropic tensorial prepreg viscosity, which …