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Full-Text Articles in Engineering
Methods For Cancer Detection, Kimberly W. Anderson, Kimberly M.L. May, Leonidas G. Bachas
Methods For Cancer Detection, Kimberly W. Anderson, Kimberly M.L. May, Leonidas G. Bachas
Chemical and Materials Engineering Faculty Patents
A method is provided for detecting an analyte indicative of a cancer or a metastatic disease condition, which utilizes the ability of the analyte to induce permeability in a barrier. The method includes providing a biosensor having a barrier which is substantially impermeable to an ion, a permeable membrane which is selective for the ion, and a detector capable of detecting the ion. The biosensor is contacted with a sample including at least one of the ion and the analyte, wherein the analyte causes at least a portion of the ion to pass through the barrier and the membrane. Passage …
Epithelial To Mesenchymal Transition And Breast Cancer, Eva Tomaskovic-Crook, Erik W. Thompson, Jean Paul Thiery
Epithelial To Mesenchymal Transition And Breast Cancer, Eva Tomaskovic-Crook, Erik W. Thompson, Jean Paul Thiery
Australian Institute for Innovative Materials - Papers
Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.