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Full-Text Articles in Engineering
Applications Of Diffusion Maps In Gene Expression Data-Based Cancer Diagnosis Analysis, Rui Xu, Donald C. Wunsch, Steven Damelin
Applications Of Diffusion Maps In Gene Expression Data-Based Cancer Diagnosis Analysis, Rui Xu, Donald C. Wunsch, Steven Damelin
Electrical and Computer Engineering Faculty Research & Creative Works
Early detection of a tumor's site of origin is particularly important for cancer diagnosis and treatment. The employment of gene expression profiles for different cancer types or subtypes has already shown significant advantages over traditional cancer classification methods. One of the major problems in cancer type recognition-oriented gene expression data analysis is the overwhelming number of measures of gene expression levels versus the small number of samples, which causes the curse of dimension issue. Here, we use diffusion maps, which interpret the eigenfunctions of Markov matrices as a system of coordinates on the original data set in order to obtain …
Classification Of Terahertz Data As A Tool For The Detection Of Cancer, Matthew J. Berryman, T. J. Rainsford
Classification Of Terahertz Data As A Tool For The Detection Of Cancer, Matthew J. Berryman, T. J. Rainsford
Faculty of Engineering - Papers (Archive)
The early detection of cancers is critical with respect to treatment and patient survival. Biopsy techniques that are currently employed for such diagnoses are invasive, time consuming and costly. A Terahertz (THz) imaging system potentially provides a fast and non-invasive way to detect and diagnose cancer. While there is proof of concept that THz can distinguish cancerous and normal tissue, the mechanisms underlying this differentiation are not well understood. A better understanding of THz spectral data can be gained through computational pattern recognition and related multivariate statistical tools. These allow for the differentiation of data into discrete and disjoint groups. …