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Full-Text Articles in Engineering
Optimization Of Cell Density And Dilution Rate In Pichia Pastoris Continuous Fermentations For Production Of Recombinant Proteins, Mehmet Inan, Michael M. Meagher, Wenhui Zhang, Chih Ping Liu
Optimization Of Cell Density And Dilution Rate In Pichia Pastoris Continuous Fermentations For Production Of Recombinant Proteins, Mehmet Inan, Michael M. Meagher, Wenhui Zhang, Chih Ping Liu
Papers in Biomolecular Engineering
This paper provides an approach for optimizing the cell density (Xc) and dilution rate (D) in a chemostat for a Pichia pastoris continuous fermentation for the extracellular production of a recombinant protein, interferon τ (INF-τ). The objective was to maximize the volumetric productivity (Q, mg INF-τ I-1 h-1), which was accomplished using response surface methodology (RSM) to model the response of Q as a function of Xc and D within the ranges 150 ≤ Xc ≤ 450 g cells (wet weight) l-1 and 0.1 μm ≤D ≤ 0.9 μm (μm =0.0678 h-1, the maximum specific growth rate obtained from a …
Development Of A Numerical Model To Simulate Pressure Distributions In Ultrasound Angioplasty, Graham Gavin, Garrett Mcguinness, Finbar Dolan, M.S. Hashmi
Development Of A Numerical Model To Simulate Pressure Distributions In Ultrasound Angioplasty, Graham Gavin, Garrett Mcguinness, Finbar Dolan, M.S. Hashmi
Conference Papers
Ultrasound Angioplasty has been shown to be effective in the removal and re-canalising of blockages in arteries (Siegel RJ, 1993). The ultrasound is delivered via a wire waveguide to the lesion location. The wire, generally, has a ball-tip at the distal end to increase transmission of the ultrasound to the surrounding fluid by causing the ball-tip to oscillate between 20– 45kHz and with displacements of up to 100mm peak-to-peak (Atar, 1999 and Yock, 1997). Pressure waves, micro streaming, cavitation and direct contact with the oscillating ball-tip affect the blockage. Most work to date has concentrated on a spherical ball-tip geometry …
Smoothing With Mixed Model Software, Long Ngo, M P. Wand
Smoothing With Mixed Model Software, Long Ngo, M P. Wand
Faculty of Engineering and Information Sciences - Papers: Part A
Smoothing methods that use basis functions with penalization can be formulated as fits in a mixed model framework. One of the major benefits is that software for mixed model analysis can be used for smoothing. We illustrate this for several smoothing models such as additive and varying coefficient models for both S-PLUS and SAS software. Code for each of the illustrations is available on the Internet.