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Full-Text Articles in Engineering
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail
Theses and Dissertations
Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley
Adipose Tissue Engineering: A Therapeutic Strategy For The Treatment Of Obesity And Glucose Intolerance, Michael A. Hendley
Theses and Dissertations
Despite available treatment options, the number of people afflicted by type 2 diabetes has steadily risen for decades. Nearly 90% of the diabetic population also suffers from obesity and the link between the two diseases is undeniable. Characterized by rapid expansion of the adipose tissue and improper lipid storage, the mishandling of lipids by adipose tissue promotes the diabetic state. Excess lipids, unable to be properly stored, build up in peripheral tissues promoting insulin resistance and type 2 diabetes. Therapeutic strategies designed to address adipose tissue lipid handling could represent a promising treatment strategy for obesity associated type 2 diabetes. …
Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews
Design And Basic Verification Of A Discrete Event Simulator For Glucose Metabolism In Human Beings, Elizabeth Andrews
Theses and Dissertations
This thesis describes the design and basic verification of a discrete event simulator for glucose metabolism in human beings. The simulator implements the glucose metabolism related behavior of various organs in the human body and tracks the blood plasma glucose level as the human body goes through a sequence of diet and exercise events. The simulator can mimic insulin resistance in various organs as well as the loss of insulin production in the pancreas and the adverse impact of these changes on the metabolic behavior of various organs. Thus, the simulator can serve as a model for people with diabetes. …