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Full-Text Articles in Engineering
Expansion Microscopy: A New Approach To Microscopic Evaluation, Ashley Ferri
Expansion Microscopy: A New Approach To Microscopic Evaluation, Ashley Ferri
Theses and Dissertations
Optical microscopy resolution is limited by the wavelengths of light and the series of microscope lenses and other optical components used to create a magnified image of cell structures in a sample. Often the cell structures are smaller or closer together than the resolution limits of a light microscope. In 2015 the Boyden group at the Massachusetts Institute of Technology (MIT) created a sample preparation technique, expansion microscopy which involves embedding biological samples in a crosslinked, swellable, hydrogel polymer that allows for uniform physical separation of cell components so that they can subsequently be resolved by light microscopy. Using the …
Development Of An Anatomically And Electrically Conductive Brain Phantom For Transcranial Magnetic Stimulation, Hamzah A. Magsood
Development Of An Anatomically And Electrically Conductive Brain Phantom For Transcranial Magnetic Stimulation, Hamzah A. Magsood
Theses and Dissertations
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for diagnostics, prognostic, and treatments of various neurological diseases. However, the lack of anatomically realistic brain phantoms has made the experimental verification of stimulation strength in the form of induced electric fields/voltages in the brain tissues an impediment to developing new TMS coils, stimulators, and treatment protocols. There are significant technological, safety, and ethical limitations to test the potential TMS treatment procedures or develop enhancements and refine them on humans or animals. This work aims to bridge the gap by introducing and developing an innovative manufacturing and fabrications process to produce a …
Role Of P-Glycoprotein In Alzheimer’S Disease For Enhanced Brain Elimination Of Amyloid-Β, Hope Holt
Role Of P-Glycoprotein In Alzheimer’S Disease For Enhanced Brain Elimination Of Amyloid-Β, Hope Holt
Theses and Dissertations
Alzheimer’s disease (AD), the most common form of neurodegenerative disorder, is characterized by deposition of amyloid-β (Aβ) plaques in the brain. Aβ monomer undergoes nucleation to form oligomers, then soluble aggregates, then fibrils which make up the plaques. Aβ oligomer species are believed to be the most neurotoxic aggregate species. Currently under investigation is a mechanism for Aβ removal from the brain, across the blood-brain barrier (BBB). P-glycoprotein (P-gp) is a membrane-bound efflux protein located on the apical, or blood, side of the BBB, which transports a wide variety of substrates. Further complicating this potential clearance mechanism is the reduction …
Ultra Short Mr Relaxometry And Histological Image Processing For Validation Of Diffusion Mri, Amin Nazaran
Ultra Short Mr Relaxometry And Histological Image Processing For Validation Of Diffusion Mri, Amin Nazaran
Theses and Dissertations
Magnetic Resonance Imaging (MRI) is an imaging modality that acquires an image with little to no damage to the tissue. MRI does not introduce foreign particles or high energy radiation into the body, making it one of the least invasive medical imaging modalities. MRI can achieve excellent soft tissue contrast and is therefore useful for diagnosis of a wide variety of diseases. While there are a wide variety of available techniques for generating contrast in MRI, there are still many open areas for research. For example, many tissues in the human body exhibit such rapid signal decay that they are …
Modification And Evaluation Of A Brain Computer Interface System To Detect Motor Intention, Christopher V. Hagerty-Hoff
Modification And Evaluation Of A Brain Computer Interface System To Detect Motor Intention, Christopher V. Hagerty-Hoff
Theses and Dissertations
It is widely understood that neurons within the brain produce electrical activity, and electroencephalography—a technique used to measure biopotentials with electrodes placed upon the scalp—has been used to observe it. Today, scientists and engineers work to interface these electrical neural signals with computers and machines through the field of Brain-Computer Interfacing (BCI). BCI systems have the potential to greatly improve the quality of life of physically handicapped individuals by replacing or assisting missing or debilitated motor functions. This research thus aims to further improve the efficacy of the BCI based assistive technologies used to aid physically disabled individuals. This study …
A Framework For An Implantable Wireless Pressure And Volume Sensor Focusing On The Diagnosis And Treatment Of Shunt Failure In Hydrocephalus Patients, Donald Monte Wichern
A Framework For An Implantable Wireless Pressure And Volume Sensor Focusing On The Diagnosis And Treatment Of Shunt Failure In Hydrocephalus Patients, Donald Monte Wichern
Theses and Dissertations
The framework for a permanently implantable wireless compliance sensor was developed and validated using laboratory experiments. The proposed sensor would measure the intracranial pressure and fluid volume in the brain and return this information to a monitoring device. The designed sensor received power remotely from the monitoring device negating the need for an implanted power source. Impedance measurement estimation techniques were suggested, studied and applied to the compliance sensing system. A new impedance measurement technique, accounting for multiple variability in the domain, was developed. An extensive simulation environment was designed and used to develop the laboratory experiments and hardware. The …