Engineering Commons^™

Engineered Fn3 Protein Has Targeted Therapeutic Effect On Mesothelin-Expressing Cancer Cells And Increases Tumor Cell Sensitivity To Chemotherapy, Allison R. Sirois, Daniela A. Deny, Yanxuan Li, Yacine D. Fall, Sarah J. Moore

Engineering: Faculty Publications

Mesothelin is a protein expressed at high levels on the cell surface in a variety of cancers, with limited expression in healthy tissues. The presence of mesothelin on tumor tissue correlates with increased invasion and metastasis, and resistance to traditional chemotherapies, through mechanisms that remain poorly understood. Molecules that specifically recognize mesothelin and interrupt its contribution to tumor progression have significant potential for targeted therapy and targeted drug delivery applications. A number of mesothelin-targeting therapies are in preclinical and clinical development, although none are currently approved for routine clinical use. In this work, we report the development of a mesothelin-targeting …