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Frequency Domain Diffuse Optical Tomography With A Single Source And Detector Via High- Speed Hypocycloid Scanning, Matthew B. Applegate, Darren Roblyer
Frequency Domain Diffuse Optical Tomography With A Single Source And Detector Via High- Speed Hypocycloid Scanning, Matthew B. Applegate, Darren Roblyer
Advances in Optics for Biotechnology, Medicine and Surgery XV
Diffuse Optical Imaging (DOI) relies on the fact that near infrared light (600-1000 nm) is strongly scattered in biological tissue, and weakly absorbed by tissue chromophores such as blood, fat, water, and melanin. In frequency domain DOI, intensity modulated light is introduced into the tissue and the observed absorption and phase changes enable absolute concentrations of these chromophores to be calculated. These concentrations provide valuable insight into tissue metabolic activity that have proven useful for a variety of clinical outcomes from exercise physiology to predicting tumor response to treatment.
Diffuse Optical Tomography (DOT) is an extension of DOI that allows …