Engineering Commons^™

Load Path Uncertainty In A Wood Structure And The Effect On Structural Reliability, Wenqi Wang, Christopher D. Eamon

Civil and Environmental Engineering Faculty Research Publications

The roof truss bearing points of a light-framed wood house were instrumented with load cells. It was found that under dead load alone, symmetric and theoretically identical truss reactions have significant variation. A similar degree of reaction discrepancy was found under the application of uplift pressures caused by hurricane winds. Analysis revealed that the majority of this discrepancy is caused by inherent uncertainties in load path. Although uncertainties in load magnitude and material resistance are accounted for in design by use of appropriate load and resistance factors, load path is generally taken to be deterministic. In this study, load path …

Reliability Analysis Of Reinforced Concrete Columns Exposed To Fire, Christopher D. Eamon, Elin A. Jensen

Civil and Environmental Engineering Faculty Research Publications

A reliability analysis is conducted on reinforced concrete columns subjected to fire load. From an evaluation of load frequency of occurrence, load random variables are taken to be dead load, sustained live load, and fire temperature. Resistance is developed for axial capacity, with random variables taken as steel yield strength, concrete compressive strength, placement of reinforcement, and section width and height. A rational interaction model based on the Rankine approach is used to estimate column capacity as a function of fire exposure time. Various factors were considered in the analysis such as fire type, load ratio, reinforcement ratio, cover, concrete …

Towards A More Robust Lower Neck Compressive Injury Tolerance - An Approach Combining Multiple Test Methodologies, Daniel Toomey, King H. Yang, N Yoganadan, F A. Pintar, C A. Van Ee

Biomedical Engineering Faculty Research Publications

Objective.The compressive tolerance of the cervical spine has traditionally been reported in terms of axial force at failure. Previous studies suggest that axial compressive force at failure is particularly sensitive to the alignment of the cervical vertebra and the end conditions of the test methodology used. The present study was designed to develop a methodology to combine the data of previous experiments into a diverse dataset utilizing multiple test methods to allow for the evaluation of the robustness of current and proposed eccentricity based injury criteria.

Methods. Data was combined from two studies composed of dynamic experiments including whole …

Why Is Ca3 More Vulnerable Than Ca1 In Experimental Models Of Controlled Cortical Impact-Induced Brain Injury?, Haojie Mao, Benjamin S. Elkin, Vinay V. Genthikatti, Barclay Morrison Iii, King H. Yang

Biomedical Engineering Faculty Research Publications

One interesting finding of controlled cortical impact (CCI) experiments is that the CA3 region of the hippocampus, which is positioned further from the impact than the CA1 region, is reported as being more injured. The current literature has suggested a positive correlation between brain tissue stretch and neuronal cell loss. However, it is counterintuitive to assume that CA3 is stretched more during CCI injury. Recent mechanical studies of the brain have reported on a level of spatial heterogeneity not previously appreciated—the finding that CA1 was significantly stiffer than all other regions tested and that CA3 was one of the most …

Reliability-Based Design Optimization Of Concrete Flexural Members Reinforced With Ductile Frp Bars, Bashar Behnam, Christopher D. Eamon

Civil and Environmental Engineering Faculty Research Publications

In recent years, ductile hybrid FRP (DHFRP) bars have been developed for use as tensile reinforcement. However, initial material costs regain high, and it is difficult to simultaneously meet strength, stiffness, ductility, and reliability demands. In this study, a reliability-based design optimization (RBDO) is conducted to determine minimum cost DHFRP bar configurations while enforcing essential constraints. Applications for bridge decks and building beams are considered, with 2, 3, and 4-material bars. It was found that optimal bar configuration has little variation for the different applications, and that overall optimized bar cost decreased as the number of bar materials increased.

Analysis Of Alternative Ductile Fiber-Reinforced Polymer Reinforcing Bar Concepts, Bashar Behnam, Christopher D. Eamon

Civil and Environmental Engineering Faculty Research Publications

Steel-reinforced concrete structural components are often associated with significant maintenance costs as a result of reinforcement corrosion. To mitigate this problem, fiber-reinforced polymer (FRP) bars have been used in place of traditional steel reinforcement for some applications. The non-ductile response of typical FRP bars is a concern, however. To overcome this problem, hybrid ductile FRP (HDFRP) bars have been developed for use in concrete flexural members with resulting ductility indices similar to sections reinforced with steel. In this study, five different HDFRP bar concepts are analyzed and compared in terms of ductility, stiffness, and relative cost. Of primary interest is …

Resistance Factors For Ductile Frp-Reinforced Concrete Flexural Members, Bashar Behnam, Christopher D. Eamon

Civil and Environmental Engineering Faculty Research Publications

To prevent damage caused by corroding reinforcement, fiber reinforced polymer (FRP) reinforcing bars have been used in place of steel in a relatively small but increasing number of structures in the civil infrastructure. A concern with the use of traditional FRP bars, however, is the resulting lack of ductility. This problem has been overcome with the development of a new generation of composite reinforcement, ductile hybrid FRP (DHFRP) bars. However, standards that address the design of DHFRP bars are unavailable, and appropriate resistance factors for the use of DHFRP reinforcement are unknown. In this study, a reliability analysis is conducted …

Reliability Analysis Of Rc Beams Exposed To Fire, Christopher D. Eamon, Elin A. Jensen

Civil and Environmental Engineering Faculty Research Publications

A procedure for conducting reliability analysis of reinforced concrete beams subjected to a fire load is presented. This involves identifying relevant load combinations, specifying critical load and resistance random variables, and establishing a high-temperature performance model for beam capacity. Based on the procedure, an initial reliability analysis is conducted using currently available data. Significant load random variables are taken to be dead load, sustained live load, and fire temperature. Resistance is in terms of moment capacity, with random variables taken as steel yield strength, concrete compressive strength, placement of reinforcement, beam width, and thermal diffusivity. A semi-empirical model is used …

Hyperglycemia Induces Differential Change In Oxidative Stress At Gene Expression And Functional Levels In Huvec And Hmvec, Hemang Patel, Juan Chen, Kumuda C. Das, Mahendra Kavdia

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Endothelial dysfunction precedes pathogenesis of vascular complications in diabetes. In recent years, the mechanisms of endothelial dysfunction were investigated to outline strategies for its treatment. However, the therapies for dysfunctional endothelium resulted in multiple clinical trial failures and remain elusive. There is a need for defining hyperglycemia-induced endothelial dysfunction with both generic and specific dysfunctional changes in endothelial cells (EC) using a systems approach. In this study, we investigated hyperglycemia-induced endothelial dysfunction in HUVEC and HMVEC. We investigated hyperglycemia-induced functional changes (superoxide (O₂‾), and hydrogen peroxide (H₂O₂) production and mitochondrial membrane polarization) …