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Full-Text Articles in Engineering
Cfd Assessment Of Respiratory Drug Delivery Efficiency In Adults And Improvements Using Controlled Condensational Growth, Ross L. Walenga
Cfd Assessment Of Respiratory Drug Delivery Efficiency In Adults And Improvements Using Controlled Condensational Growth, Ross L. Walenga
Theses and Dissertations
Pharmaceutical aerosols provide a number of advantages for treating respiratory diseases that include targeting high doses directly to the lungs and reducing exposure of other organs to the medication, which improve effectiveness and minimize side effects. However, difficulties associated with aerosolized drug delivery to the lungs include drug losses in delivery devices and in the extrathoracic region of human upper airways. Intersubject variability of extrathoracic and thoracic drug deposition is a key issue as well and should be minimized. Improvements to respiratory drug delivery efficiency have been recently proposed by Dr. P. Worth Longest and Dr. Michael Hindle through the …
Experimental And Computational Assessment Of Mechanical Circulatory Assistance Of A Patient-Specific Fontan Vessel Configuration, Steven Chopski
Experimental And Computational Assessment Of Mechanical Circulatory Assistance Of A Patient-Specific Fontan Vessel Configuration, Steven Chopski
Theses and Dissertations
The treatment of single ventricle anomalies is a formidable challenge for clinical teams caring for patients with congenital heart disease. Those patients fortunate to survive surgical palliation contend with lifelong physical limitations and late stage pathophysiology. A mechanical blood pump specifically designed to increase pressure in the great veins would augment flow through the lungs and provide hemodynamic stability until a donor heart is located. To support the development of such medical devices, this research characterized the fluid dynamics of mechanical assistance in the Fontan circulation by performing numerical analyses and particle image velocimetry (PIV) studies in a patient-specific in …
The Effects Of Micro- And Macro-Scale Geometric Parameters On Performance Of The Pleated Aerosol Filters, Shahryar Fotovati
The Effects Of Micro- And Macro-Scale Geometric Parameters On Performance Of The Pleated Aerosol Filters, Shahryar Fotovati
Theses and Dissertations
While most filters are made of pleated fibrous media, almost all existing theories of aerosol filtration are developed for flat media placed perpendicular to the air flow. Expressions developed for flat sheet media do not provide accurate information directly useful for designing a pleated filter, and therefore, most progress made in developing pleated filters is based on empiricism. This study is aimed at establishing an enabling knowledge that allows for a better design and optimization of pleated aerosol filters. This study is focused on developing a predictive simulation method that accounts for the influence of a filter’s micro-scale geometric parameters, …
Modeling Particle Filtration And Caking In Fibrous Filter Media, Seyed Alireza Hosseini
Modeling Particle Filtration And Caking In Fibrous Filter Media, Seyed Alireza Hosseini
Theses and Dissertations
This study is aimed at developing modeling methodologies for simulating the flow of air and aerosol particles through fibrous filter media made up of micro- or nano-fibers. The study also deals with modeling particle deposition (due to Brownian diffusion, interception, and inertial impaction) and particle cake formation, on or inside fibrous filters. By computing the air flow field and the trajectory of airborne particles in 3-D virtual geometries that resemble the internal microstructure of fibrous filter media, pressure drop and collection efficiency of micro- or nano-fiber filters are simulated and compared with the available experimental studies. It was demonstrated that …
Dual-Scale Modeling Of Two-Phase Fluid Transport In Fibrous Porous Media, Alireza Ashari
Dual-Scale Modeling Of Two-Phase Fluid Transport In Fibrous Porous Media, Alireza Ashari
Theses and Dissertations
The primary objective of this research is to develop a mathematical framework that could be used to model or predict the rate of fluid absorption and release in fibrous sheets made up of solid or porous fibers. In the first step, a two-scale two-phase modeling methodology is developed for studying fluid release from saturated/unsaturated thin fibrous media made up of solid fibers when brought in contact with a moving solid surface. Our macroscale model is based on the Richards’ equation for two-phase fluid transport in porous media. The required constitutive relationships, capillary pressure and relative permeability as functions of the …
Numerical Analysis Of Respiratory Aerosol Deposition: Effects Of Exhalation, Airway Constriction And Electrostatic Charge, Samir C. Vinchurkar
Numerical Analysis Of Respiratory Aerosol Deposition: Effects Of Exhalation, Airway Constriction And Electrostatic Charge, Samir C. Vinchurkar
Theses and Dissertations
The dynamics of particle laden flows are integral to the analysis of toxic particle deposition and medical respiratory aerosol delivery. Computational fluid-particle dynamics (CFPD) can play a critical role in developing a better understanding of particle laden flows, especially in a number of under-explored areas. The applications considered in this study include both the numerical aspects and the physical phenomena of respiratory aerosol transport. Objective I: Considering the effects of mesh type and grid convergence, four commonly implemented mesh styles were applied to a double bifurcation respiratory geometry and tested for flow patterns and aerosol deposition. Results indicated that the …