Engineering Commons^™

Polymeric Prodrug, David A. Puleo, Thomas D. Dziubla, Theodora Asafo-Adjei

Biomedical Engineering Faculty Patents

The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.